Showing entry for Peroxisomal N(1)-acetyl-spermine/spermidine oxidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016497
Protein NamePeroxisomal N(1)-acetyl-spermine/spermidine oxidase
Uniport IdQ6QHF9
GenePAOX
Gene Id196743
DomainAmino_oxidase
Pfam PF01593  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04146 Peroxisome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006596 polyamine biosynthetic process
Biological Process GO:0006598 polyamine catabolic process
Biological Process GO:1901307 positive regulation of spermidine biosynthetic process
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0009446 putrescine biosynthetic process
Biological Process GO:0009447 putrescine catabolic process
Biological Process GO:0046203 spermidine catabolic process
Biological Process GO:0046208 spermine catabolic process
molecular function GO:0052899 N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
molecular function GO:0052904 N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
molecular function GO:0052903 N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0046592 polyamine oxidase activity
molecular function GO:0052902 spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
molecular function GO:0052901 spermine:oxygen oxidoreductase (spermidine-forming) activity
cellular component GO:0005829 cytosol
cellular component GO:0005782 peroxisomal matrix
Reactome
Pathway Id Pathway Name
R-HSA-140179 Amine Oxidase reactions
R-HSA-141334 PAOs oxidise polyamines to amines
R-HSA-1430728 Metabolism
R-HSA-211859 Biological oxidations
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-351200 Interconversion of polyamines
R-HSA-351202 Metabolism of polyamines
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033241 Peroxisomal protein import
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2931672 BXGD018045 Cerebral hemorrhage with amyloidosis, hereditary, Dutch type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004139 Sperminidine 145.25
BXGC0015879 Chlorhexidine 504.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein