Showing entry for Sperminidine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0004139
Compound NameSperminidine
Structure
FormulaC7H19N3
InchiKeyATHGHQPFGPMSJY-UHFFFAOYSA-N
SMILESNCCCCNCCCN
InchiInChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
IUPAC(4-aminobutyl)(3-aminopropyl)amine
Molecular Weight145.25
Pubchem Id1102
Chembl IdCHEMBL19612
Targets of Information Source
DrugBank DB03566
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P0AFK9 BXGT007352 Spermidine/putrescine-binding periplasmic protein reviewed - potD experimental -
Q16881 BXGT013688 Thioredoxin reductase 1, cytoplasmic reviewed Enzyme TXNRD1 experimental -
P23181 BXGT008832 Gentamicin 3-N-acetyltransferase reviewed - aacC1 experimental -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 experimental -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 experimental -
PDB SPD
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q53396 BXGT014995 Aminoglycoside-(3)-N-acetyltransferase unreviewed aacC1 - - - - -
P0AFK9 BXGT007352 Spermidine/putrescine-binding periplasmic protein reviewed potD - - - 3200 -
P39040 BXGT010083 Trypanothione reductase reviewed TPR - - - - -
P68135 BXGT011580 Actin, alpha skeletal muscle reviewed ACTA1 - - - - -
P19623 BXGT008503 Spermidine synthase reviewed SRM Enzyme - - - -
Q2PYN0 BXGT014158 Glyoxalase II unreviewed Glo2 - - - - -
Q8II73 BXGT018273 Spermidine synthase unreviewed PF3D7_1129000 - - - - -
Q9Y5W5 BXGT022303 Wnt inhibitory factor 1 reviewed WIF1 Calcium-binding protein - - - -
P51697 BXGT010887 Gamma-hexachlorocyclohexane dehydrochlorinase reviewed linA - - - - -
P10408 BXGT007565 Protein translocase subunit SecA reviewed secA - - - - -
P52788 BXGT010953 Spermine synthase reviewed SMS - - - - -
P50264 BXGT010787 Polyamine oxidase FMS1 reviewed FMS1 - - - - -
Q9RM86 BXGT021470 4-Hydroxybutyrate CoA-transferase unreviewed abfT - - - - -
P0AG30 BXGT007361 Transcription termination factor Rho reviewed rho - - - - -
O64411 BXGT004927 Polyamine oxidase 1 reviewed MPAO1 - - - - -
Q9I6J0 BXGT020768 Spermidine-binding periplasmic protein SpuE reviewed spuE - - - 14.3 -
A0A0M3KKU5 BXGT000541 Spermidine N1-acetyltransferase unreviewed - - - - -
S5FV19 BXGT022530 Pilus tip adhesin Cpa reviewed cpa - - - - -
P31133 BXGT009509 Putrescine-binding periplasmic protein reviewed potF - - - 6400000 -
D9J2T9 BXGT003028 Ribosome inactivating protein unreviewed RIP - - - - -
Q9KL03 BXGT020937 Spermidine N(1)-acetyltransferase reviewed speG - - - - -
J3F2B0 BXGT003732 CRISPR-associated endonuclease Cas9 reviewed cas9 - - - - -
P59071 BXGT011259 Basic phospholipase A2 VRV-PL-VIIIa reviewed - - - - -
Q2FJE0 BXGT013999 50S ribosomal protein L25 reviewed rplY - - - - -
Q2FW13 BXGT014015 50S ribosomal protein L16 reviewed rplP - - - - -
Q2FW07 BXGT014012 50S ribosomal protein L4 reviewed rplD - - - - -
Q83WF5 BXGT017521 Mycinamicin VIII C21 methyl hydroxylase reviewed mycCI - - - - -
P21796 BXGT008690 Voltage-dependent anion-selective channel protein 1 reviewed VDAC1 - - - - -
Q5JIZ3 BXGT015453 N(4)-bis(aminopropyl)spermidine synthase reviewed bpsA - - - - -
G7K2D1 BXGT003548 Putative spermidine synthase unreviewed 11439099 - - - - -
Q9RTP8 BXGT021503 Divalent metal cation transporter MntH reviewed mntH - - - - -
Q9I6J0 BXGT020768 Spermidine-binding periplasmic protein SpuE reviewed spuE - - - - -
Q31QK9 BXGT025342 Polyamine aminopropyltransferase reviewed speE - - - - -
P49366 BXGT025175 Deoxyhypusine synthase reviewed DHPS - - - - -
Binding DB 50009353
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009831 Glutamate receptor ionotropic, NMDA 1 reviewed Grin1 >10000 - - -
reviewed BXGT009157 Ornithine decarboxylase reviewed ODC1 3000000 - - -
reviewed BXGT006853 Ornithine decarboxylase reviewed Odc1 2700000 - - -
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 1400 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 1110 - - -
reviewed BXGT006627 Carbonic anhydrase 3 reviewed CA3 11500 - - -
reviewed BXGT008802 Carbonic anhydrase 4 reviewed CA4 112 - - -
reviewed BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed CA5A 1220 - - -
reviewed BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed CA5B 1440 - - -
reviewed BXGT008844 Carbonic anhydrase 6 reviewed CA6 1410 - - -
reviewed BXGT010364 Carbonic anhydrase 7 reviewed CA7 1230 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 1370 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 44100 - - -
reviewed BXGT020260 Carbonic anhydrase 13 reviewed Ca13 11600 - - -
reviewed BXGT021769 Carbonic anhydrase 14 reviewed CA14 1000 - - -
reviewed BXGT019994 Carbonic anhydrase 15 reviewed Ca15 10000 - - -
CHEMBL CHEMBL19612
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P14100 BXGT007985 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed - PDE1A IC50 '>' 500000 nM
Q01061 BXGT012562 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed - PDE1B IC50 '>' 500000 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 12589 nM
P48026 BXGT010605 Diamine acetyltransferase 1 reviewed - Sat1 SSAT '=' 160 %
Q6P8J2 BXGT016461 Diamine acetyltransferase 2 reviewed - Sat2 SSAT '=' 160 %
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ki '=' 112 nM
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 6309 nM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 1230 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A Ki '=' 1220 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 23280 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 1400 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 5011 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 26121 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 12589 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 1370 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 44100 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 31622 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 8912 nM
Q9Y2D0 BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed - CA5B Ki '=' 1440 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 12589 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '=' 1110 nM
P0DMN7 BXGT007505 S-adenosylmethionine decarboxylase proenzyme 1 reviewed - Amd1 AdoMetDC '=' 43 %
P07451 BXGT006627 Carbonic anhydrase 3 reviewed - CA3 Ki '=' 11500 nM
P27117 BXGT009157 Ornithine decarboxylase reviewed - ODC1 Ki '=' 3000000 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
P58735 BXGT011245 Sulfate anion transporter 1 reviewed - Slc26a1 Vmax '=' 4 umol/min/mg
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 Ki '=' 1410 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 31622 nM
P58735 BXGT011245 Sulfate anion transporter 1 reviewed - Slc26a1 Km '=' 151000 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
Q9D6N1 BXGT020260 Carbonic anhydrase 13 reviewed - Ca13 Ki '=' 11600 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Ki '=' 1000 nM
Q99N23 BXGT019994 Carbonic anhydrase 15 reviewed - Ca15 Ki '=' 10000 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 39810 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 398 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 12589 nM
Q9H015 BXGT020432 Solute carrier family 22 member 4 reviewed Transporter SLC22A4 Activity - - -
Q6QHF9 BXGT016497 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase reviewed - PAOX Stability - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 10621 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Activity - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 2058 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 12589 nM
P09057 BXGT006853 Ornithine decarboxylase reviewed - Odc1 Ki '=' 2700000 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 '>' 1000000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00016 Peanut Arachis hypogaea Nuts
BXGF00022 Oat Avena sativa Cereals and cereal products
BXGF00059 Arabica coffee Coffea arabica Coffee and coffee products
BXGF00065 Cucumber Cucumis sativus Gourds
BXGF00085 Soy bean Glycine max Soy
BXGF00096 Grass pea Lathyrus sativus Pulses
BXGF00105 Apple Malus pumila Fruits
BXGF00132 Scarlet bean Phaseolus coccineus Pulses
BXGF00133 Lima bean Phaseolus lunatus Pulses
BXGF00134 Common bean Phaseolus vulgaris Pulses
BXGF00141 Common pea Pisum sativum Pulses
BXGF00153 Radish Raphanus sativus Vegetables
BXGF00171 Garden tomato Solanum lycopersicum Vegetables
BXGF00173 Garden tomato (var.) Solanum lycopersicum var. lycopersicum Vegetables
BXGF00197 Broad bean Vicia faba Pulses
BXGF00198 Adzuki bean Vigna angularis Pulses
BXGF00199 Gram bean Vigna mungo Pulses
BXGF00200 Mung bean Vigna radiata Pulses
BXGF00202 Cowpea Vigna unguiculata Pulses
BXGF00205 Corn Zea mays Cereals and cereal products
BXGF00400 French plantain Musa X paradisiaca Fruits
BXGF00466 Winged bean Psophocarpus tetragonolobus Pulses
BXGF00805 Mushrooms Vegetables
BXGF00810 Cereals and cereal products Cereals and cereal products
BXGF00823 Fruits Fruits
BXGF00834 Yellow wax bean Phaseolus vulgaris Pulses
BXGF00835 Green bean Phaseolus vulgaris Pulses
BXGF02527 Nicotiana tabacum Nicotiana tabacum Medicinal Plant
BXGF03176 Capparis masaikai Capparis masaikai Medicinal Plant
BXGF03221 Nectandra pichurim Nectandra pichurim Human Edible Plant
BXGF03496 Pityrogramma tartarea Pityrogramma tartarea Others
BXGF04820 Panax ginseng Panax ginseng 0
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease