Showing entry for Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018521
Protein NameKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Uniport IdQ8N5Z0
GeneAADAT
Gene Id51166
DomainAminotran_1_2
Pfam PF00155  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00310 Lysine degradation
1. Metabolism 1.5 Amino acid metabolism hsa00380 Tryptophan metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01210 2-Oxocarboxylic acid metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:1901605 alpha-amino acid metabolic process
Biological Process GO:0009058 biosynthetic process
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0070189 kynurenine metabolic process
Biological Process GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine
Biological Process GO:0006554 lysine catabolic process
Biological Process GO:0006569 tryptophan catabolic process
molecular function GO:0047536 2-aminoadipate transaminase activity
molecular function GO:0016212 kynurenine-oxoglutarate transaminase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0008483 transaminase activity
cellular component GO:0005759 mitochondrial matrix
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-71064 Lysine catabolism
R-HSA-71240 Tryptophan catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004936 BXGD000295 Mental disorders Mental Disorders
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0341747 BXGD007421 Detrusor and sphincter dyssynergia
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2930619 BXGD017890 Sex Differentiation Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0003705 Chloride 35.45
BXGC0006162 L-Glutamic acid 147.13
BXGC0034206 pyridoxamine phosphate 248.06
BXGC0043088 Pyridoxal Phosphate 247.02
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein