Showing entry for Cyclic GMP-AMP synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018528
Protein NameCyclic GMP-AMP synthase
Uniport IdQ8N884
GeneCGAS
Gene Id115004
DomainMab-21
Pfam PF03281  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04623 Cytosolic DNA-sensing pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0071360 cellular response to exogenous dsRNA
Biological Process GO:0051607 defense response to virus
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0006281 DNA repair
Biological Process GO:0045087 innate immune response
Biological Process GO:2000042 negative regulation of double-strand break repair via homologous recombination
Biological Process GO:0038001 paracrine signaling
Biological Process GO:0043950 positive regulation of cAMP-mediated signaling
Biological Process GO:2000774 positive regulation of cellular senescence
Biological Process GO:0010753 positive regulation of cGMP-mediated signaling
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:0032481 positive regulation of type I interferon production
Biological Process GO:0002637 regulation of immunoglobulin production
Biological Process GO:0050863 regulation of T cell activation
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0061501 cyclic-GMP-AMP synthase activity
molecular function GO:0003677 DNA binding
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0005525 GTP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
cellular component GO:0005829 cytosol
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0035861 site of double-strand break
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-1834941 STING mediated induction of host immune responses
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0024793 BXGD001805 Marek Disease Infections; Immune System Diseases; Hemic and Lymphatic Diseases; Animal Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035369 BXGD002543 Retroviridae Infections Infections
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0233681 BXGD004600 Grandiose delusions Mental Disorders; Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0393591 BXGD008102 AICARDI-GOUTIERES SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Nervous System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424101 BXGD008519 Inattention
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0518948 BXGD009072 Chlamydia trachomatis infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0940937 BXGD011490 precancerous lesions
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1536085 BXGD013334 Geographic Atrophy Eye Diseases
C3267073 BXGD018613 Autoinflammatory disease
C3860213 BXGD019844 Autoinflammatory disorder
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein