protein

Showing entry for eIF-2-alpha kinase activator GCN1

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT019358
Protein Name	eIF-2-alpha kinase activator GCN1
Uniport Id	Q92616
Gene	GCN1
Gene Id	10985
Domain	-
Pfam	-
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0034198	cellular response to amino acid starvation
Biological Process	GO:1990253	cellular response to leucine starvation
Biological Process	GO:0033674	positive regulation of kinase activity
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
molecular function	GO:0045296	cadherin binding
molecular function	GO:0019901	protein kinase binding
molecular function	GO:0019887	protein kinase regulator activity
molecular function	GO:0043022	ribosome binding
molecular function	GO:0003723	RNA binding
molecular function	GO:0008135	translation factor activity, RNA binding
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0016020	membrane
cellular component	GO:0005844	polysome
cellular component	GO:0005840	ribosome

Reactome

Pathway Id	Pathway Name
R-HSA-2262752	Cellular responses to stress
R-HSA-8953897	Cellular responses to external stimuli
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023524	BXGD001681	Leukoencephalopathy, Progressive Multifocal	Infections; Nervous System Diseases
C0025149	BXGD001826	Medulloblastoma	Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0278510	BXGD006526	Childhood Medulloblastoma	Neoplasms
C0278876	BXGD006607	Adult Medulloblastoma	Neoplasms
C0740279	BXGD009973	Cerebellar atrophy

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0022863	n.a		420.18

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}