Showing entry for Erbin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019736
Protein NameErbin
Uniport IdQ96RT1
GeneERBIN
Gene Id55914
DomainLRR_8; PDZ
Pfam PF13855   PF00595  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045175 basal protein localization
Biological Process GO:0007155 cell adhesion
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0038128 ERBB2 signaling pathway
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0071638 negative regulation of monocyte chemotactic protein-1 production
Biological Process GO:0032088 negative regulation of NF-kappaB transcription factor activity
Biological Process GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Process GO:0046579 positive regulation of Ras protein signal transduction
Biological Process GO:0006605 protein targeting
Biological Process GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0032495 response to muramyl dipeptide
Biological Process GO:0007165 signal transduction
molecular function GO:0005176 ErbB-2 class receptor binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0005200 structural constituent of cytoskeleton
cellular component GO:0009925 basal plasma membrane
cellular component GO:0005604 basement membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0030054 cell junction
cellular component GO:0005737 cytoplasm
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0030056 hemidesmosome
cellular component GO:0031965 nuclear membrane
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1227986 Signaling by ERBB2
R-HSA-1227990 Signaling by ERBB2 in Cancer
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling
R-HSA-9664565 Signaling by ERBB2 KD Mutants
R-HSA-9665230 Drug resistance in ERBB2 KD mutants
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib
R-HSA-9665348 Signaling by ERBB2 ECD mutants
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007133 BXGD000442 Carcinoma, Papillary Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0014527 BXGD000923 Epidermolysis Bullosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0079294 BXGD003070 Epidermolysis Bullosa Dystrophica Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206693 BXGD004244 Medullary carcinoma Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0206704 BXGD004254 Carcinoma, Large Cell Neoplasms
C0340427 BXGD007329 Familial dilated cardiomyopathy Cardiovascular Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0740277 BXGD009972 Bile duct carcinoma Digestive System Diseases; Neoplasms
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1285654 BXGD012172 Memory performance
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein