Showing entry for Plakophilin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019977
Protein NamePlakophilin-2
Uniport IdQ99959
GenePKP2
Gene Id5318
DomainArm
Pfam PF00514  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
Biological Process GO:0086002 cardiac muscle cell action potential involved in contraction
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0086019 cell-cell signaling involved in cardiac conduction
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0070268 cornification
Biological Process GO:0002159 desmosome assembly
Biological Process GO:0002934 desmosome organization
Biological Process GO:0007507 heart development
Biological Process GO:0045110 intermediate filament bundle assembly
Biological Process GO:0031424 keratinization
Biological Process GO:0048496 maintenance of animal organ identity
Biological Process GO:0010765 positive regulation of sodium ion transport
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0086005 ventricular cardiac muscle cell action potential
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis
molecular function GO:0045294 alpha-catenin binding
molecular function GO:0045296 cadherin binding
molecular function GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
molecular function GO:0019215 intermediate filament binding
molecular function GO:0044325 ion channel binding
molecular function GO:0060090 molecular adaptor activity
molecular function GO:0005080 protein kinase C binding
molecular function GO:0017080 sodium channel regulator activity
cellular component GO:0005912 adherens junction
cellular component GO:0005911 cell-cell junction
cellular component GO:0030054 cell junction
cellular component GO:0001533 cornified envelope
cellular component GO:0005737 cytoplasm
cellular component GO:0030057 desmosome
cellular component GO:0016021 integral component of membrane
cellular component GO:0014704 intercalated disc
cellular component GO:0005882 intermediate filament
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030591 BXGD002247 Paroxysmal ventricular tachycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0035828 BXGD002566 Romano-Ward Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0037052 BXGD002662 Sick Sinus Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039240 BXGD002804 Supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085614 BXGD003205 First degree atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085615 BXGD003206 Right bundle branch block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0155707 BXGD003813 Trifascicular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0264893 BXGD005433 Nodal rhythm disorder Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0267026 BXGD005727 Actinic cheilitis Stomatognathic Diseases
C0340493 BXGD007338 Paroxysmal familial ventricular fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0344424 BXGD007669 Ventricular Arrhythmia by ECG Finding
C0348626 BXGD007878 Other specified cardiac arrhythmias Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0520806 BXGD009113 Unexplained sudden death Pathological Conditions, Signs and Symptoms
C0520886 BXGD009118 ST segment elevation (finding) Cardiovascular Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0750197 BXGD010231 Sustained ventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0855329 BXGD011084 Electrocardiogram change
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1399226 BXGD013003 Ectopic rhythm Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1611743 BXGD013456 Familial (FPAH)
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1832600 BXGD013861 Naxos disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1834481 BXGD013975 CARDIOMYOPATHY, DILATED, 1S Cardiovascular Diseases
C1836906 BXGD014177 Arrhythmogenic Right Ventricular Dysplasia, Familial, 9 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1883529 BXGD016597 Ventricular Arrhythmia, CTCAE 3.0
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960469 BXGD016664 Left ventricular noncompaction Cardiovascular Diseases
C2063326 BXGD016902 Right ventricular cardiomyopathy Cardiovascular Diseases
C2585653 BXGD017139 Persistent atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2748542 BXGD017596 CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C3160712 BXGD018467 Palpitations, CTCAE
C3468561 BXGD018908 familial atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3715208 BXGD019451 AV Block First Degree by ECG Finding Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4476545 BXGD022826 Dilatation of the ventricular cavity Cardiovascular Diseases
C4551804 BXGD023411 Brugada Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4553764 BXGD023550 Ventricular Arrhythmia, CTCAE 5.0
C4703449 BXGD023648 Aborted sudden cardiac death Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein