Showing entry for Serine/threonine-protein kinase WNK3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020188
Protein NameSerine/threonine-protein kinase WNK3
Uniport IdQ9BYP7
GeneWNK3
Gene Id65267
DomainOSR1_C; Pkinase
Pfam PF12202   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006884 cell volume homeostasis
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0050801 ion homeostasis
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0090188 negative regulation of pancreatic juice secretion
Biological Process GO:0010766 negative regulation of sodium ion transport
Biological Process GO:0007231 osmosensory signaling pathway
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0051928 positive regulation of calcium ion transport
Biological Process GO:0032414 positive regulation of ion transmembrane transporter activity
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:1903288 positive regulation of potassium ion import across plasma membrane
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:2000651 positive regulation of sodium ion transmembrane transporter activity
Biological Process GO:0010765 positive regulation of sodium ion transport
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0090279 regulation of calcium ion import
Biological Process GO:1904062 regulation of cation transmembrane transport
molecular function GO:0005524 ATP binding
molecular function GO:0019869 chloride channel inhibitor activity
molecular function GO:0019870 potassium channel inhibitor activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005912 adherens junction
cellular component GO:0005923 bicellular tight junction
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1504404 BXGD013141 Hippocampal sclerosis
C1846055 BXGD014779 Siderius X-linked mental retardation syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0012352 Chelerythrine 348.12
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein