Showing entry for (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0050099
Compound Name(2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione
Structure
FormulaC19H22O7
InchiKeyNEQZWEXWOFPKOT-BYRRXHGESA-N
SMILESCOc1cc2/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@@H](OC(=O)c2c(c1)O)C
InchiInChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
IUPAC(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
Molecular Weight362.14
Pubchem Id9863776
Chembl IdCHEMBL1077979
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB 1FM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed MAPK1 Kinase - - - -
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 reviewed MAP2K7 Kinase - - - -
Binding DB 50042034
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 reviewed Kinase MAP2K7 - 1300 - -
reviewed BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 - 80 - -
reviewed BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 - 6800 - -
reviewed BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 - 80 - -
reviewed BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 - 11 - -
reviewed BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 - 8.1 - -
reviewed BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 - 9 - -
reviewed BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 - 8 - -
reviewed BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 - 2.9 - -
reviewed BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 - 738 - -
reviewed BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 - 5.6 - -
CHEMBL CHEMBL1077979
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9Y6E0 BXGT022327 Serine/threonine-protein kinase 24 reviewed Kinase STK24 Inhibition '=' -39 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 IC50 '=' 80 nM
Q6ZN16 BXGT016630 Mitogen-activated protein kinase kinase kinase 15 reviewed - MAP3K15 Inhibition '=' -13 %
Q9Y2H1 BXGT022233 Serine/threonine-protein kinase 38-like reviewed Kinase STK38L Inhibition '=' -133 %
Q9HC98 BXGT020528 Serine/threonine-protein kinase Nek6 reviewed Kinase NEK6 Inhibition '=' -9 %
Q9H093 BXGT020433 NUAK family SNF1-like kinase 2 reviewed Kinase NUAK2 Inhibition '=' -17 %
Q9NRP7 BXGT021192 Serine/threonine-protein kinase 36 reviewed Kinase STK36 Activity '=' 0 %
Q92772 BXGT019371 Cyclin-dependent kinase-like 2 reviewed Kinase CDKL2 Activity '=' 8 %
Q16566 BXGT013639 Calcium/calmodulin-dependent protein kinase type IV reviewed Kinase CAMK4 Inhibition '=' 30 %
P50613 BXGT010815 Cyclin-dependent kinase 7 reviewed Kinase CDK7 Inhibition '=' -3 %
P78527 BXGT011846 DNA-dependent protein kinase catalytic subunit reviewed Kinase PRKDC Inhibition '=' -31 %
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Inhibition '=' -129 %
Q13164 BXGT013322 Mitogen-activated protein kinase 7 reviewed Kinase MAPK7 Inhibition '=' 12 %
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Inhibition '=' 14 %
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 reviewed Kinase ERBB3 Inhibition '=' -203 %
Q13418 BXGT013351 Integrin-linked protein kinase reviewed Kinase ILK Inhibition '=' -28 %
Q8IVH8 BXGT018345 Mitogen-activated protein kinase kinase kinase kinase 3 reviewed Kinase MAP4K3 Inhibition '=' 3 %
Q9P289 BXGT021300 Serine/threonine-protein kinase 26 reviewed Kinase STK26 Inhibition '=' -29 %
P30530 BXGT009431 Tyrosine-protein kinase receptor UFO reviewed Kinase AXL Inhibition '=' -33 %
P11362 BXGT007693 Fibroblast growth factor receptor 1 reviewed Kinase FGFR1 Inhibition '=' 18 %
P42685 BXGT010332 Tyrosine-protein kinase FRK reviewed Kinase FRK Inhibition '=' -9 %
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Inhibition '=' 8 %
O60307 BXGT004870 Microtubule-associated serine/threonine-protein kinase 3 reviewed Kinase MAST3 Inhibition '=' 39 %
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Inhibition '=' -29 %
Q14164 BXGT013451 Inhibitor of nuclear factor kappa-B kinase subunit epsilon reviewed Kinase IKBKE Inhibition '=' -28 %
Q76MJ5 BXGT016871 Serine/threonine-protein kinase/endoribonuclease IRE2 reviewed Kinase ERN2 Inhibition '=' 21 %
O95835 BXGT005400 Serine/threonine-protein kinase LATS1 reviewed Kinase LATS1 Inhibition '=' 9 %
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 reviewed Kinase MAP2K7 Inhibition '=' 18 %
Q13233 BXGT013330 Mitogen-activated protein kinase kinase kinase 1 reviewed Kinase MAP3K1 Inhibition '=' 51 %
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 reviewed Kinase TBK1 Inhibition '=' -28 %
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Inhibition '=' -22 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Inhibition '=' 95 %
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Inhibition '=' -14 %
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Inhibition '=' -55 %
P07947 BXGT006701 Tyrosine-protein kinase Yes reviewed Kinase YES1 Inhibition '=' 8 %
P41240 BXGT010242 Tyrosine-protein kinase CSK reviewed Kinase CSK Inhibition '=' -1 %
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Inhibition '=' -35 %
P08581 BXGT006794 Hepatocyte growth factor receptor reviewed Kinase MET Inhibition '=' -11 %
Q04912 BXGT012790 Macrophage-stimulating protein receptor reviewed Kinase MST1R Inhibition '=' -37 %
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA IC50 '=' 250 nM
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 reviewed Kinase MAP2K7 IC50 '=' 300 nM
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 IC50 '=' 11 nM
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 Inhibition - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 '=' 6800 nM
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 IC50 '=' 8 nM
Q15750 BXGT013592 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 reviewed Kinase TAB1 IC50 '=' 8 nM
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 reviewed Kinase MAP2K7 IC50 '=' 1300 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 '=' 80 nM
Q96GX5 BXGT019668 Serine/threonine-protein kinase greatwall reviewed Kinase MASTL Inhibition '=' 51 %
Q9UK32 BXGT021736 Ribosomal protein S6 kinase alpha-6 reviewed Kinase RPS6KA6 Activity '=' 3 %
Q13557 BXGT013376 Calcium/calmodulin-dependent protein kinase type II subunit delta reviewed Kinase CAMK2D Inhibition '=' -41 %
Q9NYL2 BXGT021259 Mitogen-activated protein kinase kinase kinase 20 reviewed Kinase MAP3K20 Activity '=' 2 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 IC50 '=' 6 nM
Q9H2K8 BXGT020455 Serine/threonine-protein kinase TAO3 reviewed Kinase TAOK3 Inhibition '=' 39 %
Q86Y07 BXGT017631 Serine/threonine-protein kinase VRK2 reviewed Kinase VRK2 Inhibition '=' 20 %
Q9BYP7 BXGT020188 Serine/threonine-protein kinase WNK3 reviewed Kinase WNK3 Inhibition '=' -21 %
Q9NRP7 BXGT021192 Serine/threonine-protein kinase 36 reviewed Kinase STK36 Activity '=' 7 %
Q9NSY1 BXGT021209 BMP-2-inducible protein kinase reviewed Kinase BMP2K Activity '=' 68 %
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform reviewed Kinase PIK3CB Inhibition '=' -21 %
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 Activity '=' 4 %
O75460 BXGT005127 Serine/threonine-protein kinase/endoribonuclease IRE1 reviewed Kinase ERN1 Inhibition '=' -156 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Inhibition '=' 45 %
Q9UK32 BXGT021736 Ribosomal protein S6 kinase alpha-6 reviewed Kinase RPS6KA6 Inhibition '=' 45 %
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 reviewed Kinase RPS6KB1 Inhibition '=' 45 %
O75582 BXGT005137 Ribosomal protein S6 kinase alpha-5 reviewed Kinase RPS6KA5 Inhibition '=' 45 %
Q15349 BXGT013558 Ribosomal protein S6 kinase alpha-2 reviewed Kinase RPS6KA2 Inhibition '=' 45 %
O75676 BXGT005144 Ribosomal protein S6 kinase alpha-4 reviewed Kinase RPS6KA4 Inhibition '=' 45 %
Q9UBS0 BXGT026113 Ribosomal protein S6 kinase beta-2 reviewed Kinase RPS6KB2 Inhibition '=' 45 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Inhibition '=' 45 %
P46734 BXGT010537 Dual specificity mitogen-activated protein kinase kinase 3 reviewed Kinase MAP2K3 Activity '=' 22 %
O95819 BXGT005398 Mitogen-activated protein kinase kinase kinase kinase 4 reviewed Kinase MAP4K4 Inhibition '=' 15 %
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 reviewed Kinase MAP2K2 Activity '=' 0 %
Q9HC98 BXGT020528 Serine/threonine-protein kinase Nek6 reviewed Kinase NEK6 Inhibition '=' 4 %
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 reviewed Kinase MAP2K4 IC50 '>' 3000 nM
P30291 BXGT009417 Wee1-like protein kinase reviewed Kinase WEE1 Inhibition '=' 3 %
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 reviewed Kinase EIF2AK3 Inhibition '=' -10 %
Q7KZI7 BXGT016990 Serine/threonine-protein kinase MARK2 reviewed Kinase MARK2 Inhibition '=' 3 %
P49116 BXGT010678 Nuclear receptor subfamily 2 group C member 2 reviewed Nuclear receptor NR2C2 INH '=' 6 nM
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 IC50 '=' 80 nM
Q13535 BXGT013370 Serine/threonine-protein kinase ATR reviewed Kinase ATR Inhibition '=' 2 %
Q13554 BXGT013374 Calcium/calmodulin-dependent protein kinase type II subunit beta reviewed Kinase CAMK2B Inhibition '=' -52 %
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB Inhibition '=' 18 %
P53779 BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 Inhibition '=' -14 %
P51617 BXGT010868 Interleukin-1 receptor-associated kinase 1 reviewed Kinase IRAK1 Inhibition '=' -6 %
Q7KZI7 BXGT016990 Serine/threonine-protein kinase MARK2 reviewed Kinase MARK2 Inhibition '=' -23 %
P52564 BXGT010932 Dual specificity mitogen-activated protein kinase kinase 6 reviewed Kinase MAP2K6 Inhibition '=' 54 %
Q15208 BXGT013550 Serine/threonine-protein kinase 38 reviewed Kinase STK38 Inhibition '=' -100 %
P27448 BXGT009183 MAP/microtubule affinity-regulating kinase 3 reviewed Kinase MARK3 Inhibition '=' 3 %
Q07002 BXGT012908 Cyclin-dependent kinase 18 reviewed Kinase CDK18 Inhibition '=' 21 %
O00750 BXGT003943 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta reviewed Kinase PIK3C2B Inhibition '=' 8 %
Q92772 BXGT019371 Cyclin-dependent kinase-like 2 reviewed Kinase CDKL2 Activity '=' 76 %
Q13163 BXGT013321 Dual specificity mitogen-activated protein kinase kinase 5 reviewed Kinase MAP2K5 Activity '=' 0 %
Q86UE8 BXGT017612 Serine/threonine-protein kinase tousled-like 2 reviewed Kinase TLK2 Inhibition '=' -1 %
P36894 BXGT009939 Bone morphogenetic protein receptor type-1A reviewed Kinase BMPR1A Inhibition '=' 73 %
Q13557 BXGT013376 Calcium/calmodulin-dependent protein kinase type II subunit delta reviewed Kinase CAMK2D Inhibition '=' -52 %
P46108 BXGT010509 Adapter molecule crk reviewed - CRK Inhibition '=' -14 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 IC50 '=' 8 nM
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 reviewed Kinase MAP2K2 Activity '=' 0 %
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB Activity '=' 0 %
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Activity '=' 0 %
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Inhibition '=' 6 %
Q8TDX7 BXGT018817 Serine/threonine-protein kinase Nek7 reviewed Kinase NEK7 Inhibition '=' -28 %
Q9Y572 BXGT022289 Receptor-interacting serine/threonine-protein kinase 3 reviewed Kinase RIPK3 Inhibition '=' -60 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 Inhibition '=' 90 %
O75385 BXGT005121 Serine/threonine-protein kinase ULK1 reviewed Kinase ULK1 Inhibition '=' -128 %
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 reviewed Kinase MAP2K4 Inhibition '=' 26 %
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB Inhibition '=' -3 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Inhibition '=' 65 %
Q9BZL6 BXGT020199 Serine/threonine-protein kinase D2 reviewed Kinase PRKD2 Activity '=' 2 %
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Inhibition '=' -40 %
P06493 BXGT006445 Cyclin-dependent kinase 1 reviewed Kinase CDK1 Inhibition '=' 46 %
Q96S38 BXGT026126 Ribosomal protein S6 kinase delta-1 reviewed Kinase RPS6KC1 Inhibition '=' -50 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Inhibition '=' -25 %
Q8N4C8 BXGT018510 Misshapen-like kinase 1 reviewed Kinase MINK1 Inhibition '=' 15 %
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 reviewed Kinase PRKAA1 Inhibition '=' 33 %
O14966 BXGT024179 Ras-related protein Rab-7L1 reviewed - RAB29 Inhibition '=' 56 %
O14967 BXGT026127 Calmegin reviewed Chaperone CLGN Inhibition '=' 55 %
Q96GD4 BXGT019667 Aurora kinase B reviewed Kinase AURKB Inhibition '=' 55 %
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha reviewed Kinase CAMK2A Inhibition '=' -52 %
P21127 BXGT008623 Cyclin-dependent kinase 11B reviewed Kinase CDK11B Inhibition '=' -21 %
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Inhibition '=' 30 %
Q06418 BXGT012875 Tyrosine-protein kinase receptor TYRO3 reviewed Kinase TYRO3 Inhibition '=' 18 %
Q96GD4 BXGT019667 Aurora kinase B reviewed Kinase AURKB Inhibition '=' 58 %
Q9Y263 BXGT022220 Phospholipase A-2-activating protein reviewed Enzyme modulator PLAA IC50 '=' 11 nM
Q13163 BXGT013321 Dual specificity mitogen-activated protein kinase kinase 5 reviewed Kinase MAP2K5 Activity '=' 0 %
P16234 BXGT008209 Platelet-derived growth factor receptor alpha reviewed Kinase PDGFRA Activity '=' 1 %
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 reviewed Kinase KDR Activity '=' 5 %
P27448 BXGT009183 MAP/microtubule affinity-regulating kinase 3 reviewed Kinase MARK3 Inhibition '=' -42 %
Q9UBS0 BXGT026113 Ribosomal protein S6 kinase beta-2 reviewed Kinase RPS6KB2 Inhibition '=' 54 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 Activity - - -
Q04771 BXGT012783 Activin receptor type-1 reviewed Kinase ACVR1 Activity '=' 1 %
Q9UK32 BXGT021736 Ribosomal protein S6 kinase alpha-6 reviewed Kinase RPS6KA6 Activity '=' 34 %
P43403 BXGT010385 Tyrosine-protein kinase ZAP-70 reviewed Kinase ZAP70 Inhibition '=' 63 %
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT Activity '=' 20 %
P15056 BXGT008075 Serine/threonine-protein kinase B-raf reviewed Kinase BRAF Inhibition '=' -18 %
Q13555 BXGT013375 Calcium/calmodulin-dependent protein kinase type II subunit gamma reviewed Kinase CAMK2G Inhibition '=' -52 %
O14936 BXGT004114 Peripheral plasma membrane protein CASK reviewed Kinase CASK Inhibition '=' -17 %
Q00534 BXGT012533 Cyclin-dependent kinase 6 reviewed Kinase CDK6 Inhibition '=' 68 %
P78527 BXGT011846 DNA-dependent protein kinase catalytic subunit reviewed Kinase PRKDC Inhibition '=' 21 %
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC Inhibition '=' 8 %
P07332 BXGT006601 Tyrosine-protein kinase Fes/Fps reviewed Kinase FES Inhibition '=' 67 %
P48426 BXGT010630 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha reviewed Kinase PIP4K2A Inhibition '=' 16 %
Q96BR1 BXGT019627 Serine/threonine-protein kinase Sgk3 reviewed - SGK3 Inhibition '=' -1 %
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Inhibition '=' 61 %
P46734 BXGT010537 Dual specificity mitogen-activated protein kinase kinase 3 reviewed Kinase MAP2K3 Inhibition '=' 33 %
Q9Y2U5 BXGT022248 Mitogen-activated protein kinase kinase kinase 2 reviewed Kinase MAP3K2 Inhibition '=' -15 %
Q13177 BXGT013323 Serine/threonine-protein kinase PAK 2 reviewed Kinase PAK2 Inhibition '=' -3 %
Q58A45 BXGT026131 PAN2-PAN3 deadenylation complex subunit PAN3 reviewed Kinase PAN3 Inhibition '=' -14 %
P46734 BXGT010537 Dual specificity mitogen-activated protein kinase kinase 3 reviewed Kinase MAP2K3 Activity '=' 1 %
Q5TCX8 BXGT015852 Mitogen-activated protein kinase kinase kinase 21 reviewed Kinase MAP3K21 Inhibition '=' -35 %
Q9Y5S2 BXGT022301 Serine/threonine-protein kinase MRCK beta reviewed Kinase CDC42BPB Inhibition '=' -76 %
Q13188 BXGT013324 Serine/threonine-protein kinase 3 reviewed Kinase STK3 Inhibition '=' -64 %
Q00536 BXGT012535 Cyclin-dependent kinase 16 reviewed Kinase CDK16 Inhibition '=' -6 %
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 reviewed Kinase MAP2K4 Activity '=' 19 %
P16234 BXGT008209 Platelet-derived growth factor receptor alpha reviewed Kinase PDGFRA Activity '=' 44 %
Q9Y3S1 BXGT022266 Serine/threonine-protein kinase WNK2 reviewed Kinase WNK2 Inhibition '=' -21 %
Q86UX6 BXGT017614 Serine/threonine-protein kinase 32C reviewed Kinase STK32C Inhibition '=' -1 %
Q16584 BXGT013642 Mitogen-activated protein kinase kinase kinase 11 reviewed Kinase MAP3K11 Inhibition '=' -1 %
O95747 BXGT005393 Serine/threonine-protein kinase OSR1 reviewed Kinase OXSR1 Inhibition '=' 72 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Inhibition '=' 10 %
P07947 BXGT006701 Tyrosine-protein kinase Yes reviewed Kinase YES1 Potency - 2442 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Inhibition '=' 14 %
P16591 BXGT008246 Tyrosine-protein kinase Fer reviewed Kinase FER Inhibition '=' -17 %
Q92918 BXGT019394 Mitogen-activated protein kinase kinase kinase kinase 1 reviewed Kinase MAP4K1 Inhibition '=' 77 %
P51957 BXGT010910 Serine/threonine-protein kinase Nek4 reviewed Kinase NEK4 Inhibition '=' 18 %
Q00536 BXGT012535 Cyclin-dependent kinase 16 reviewed Kinase CDK16 Inhibition '=' -18 %
P37173 BXGT009970 TGF-beta receptor type-2 reviewed Kinase TGFBR2 Activity '=' 0 %
Q8TDX7 BXGT018817 Serine/threonine-protein kinase Nek7 reviewed Kinase NEK7 Inhibition '=' 4 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Activity '=' 0 %
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT Activity '=' 0 %
O75676 BXGT005144 Ribosomal protein S6 kinase alpha-4 reviewed Kinase RPS6KA4 Inhibition '=' 39 %
P25098 BXGT009015 Beta-adrenergic receptor kinase 1 reviewed Kinase GRK2 Inhibition '=' -17 %
Q13555 BXGT013375 Calcium/calmodulin-dependent protein kinase type II subunit gamma reviewed Kinase CAMK2G Inhibition '=' -45 %
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 Inhibition '=' 2 %
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 reviewed Kinase CHEK2 Inhibition '=' 12 %
P29317 BXGT009331 Ephrin type-A receptor 2 reviewed Kinase EPHA2 Inhibition '=' -20 %
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ Inhibition '=' 42 %
P35557 BXGT009846 Glucokinase reviewed Kinase GCK Inhibition '=' 36 %
Q07912 BXGT012947 Activated CDC42 kinase 1 reviewed Kinase TNK2 Inhibition '=' -17 %
O14965 BXGT004117 Aurora kinase A reviewed Kinase AURKA Inhibition '=' 59 %
Q9NWZ3 BXGT021239 Interleukin-1 receptor-associated kinase 4 reviewed Kinase IRAK4 Inhibition '=' -66 %
Q86SG6 BXGT026136 Serine/threonine-protein kinase Nek8 reviewed Kinase NEK8 Inhibition '=' -9 %
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Inhibition '=' -17 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 IC50 '=' 9 nM
P21127 BXGT008623 Cyclin-dependent kinase 11B reviewed Kinase CDK11B Inhibition '=' -1 %
Q96Q15 BXGT025610 Serine/threonine-protein kinase SMG1 reviewed Kinase SMG1 Inhibition '=' -8 %
Q7L7X3 BXGT016997 Serine/threonine-protein kinase TAO1 reviewed Kinase TAOK1 Inhibition '=' 39 %
Q13470 BXGT013359 Non-receptor tyrosine-protein kinase TNK1 reviewed Kinase TNK1 Inhibition '=' 13 %
Q8IYT8 BXGT018370 Serine/threonine-protein kinase ULK2 reviewed Kinase ULK2 Inhibition '=' -141 %
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB Activity '=' 1 %
Q13163 BXGT013321 Dual specificity mitogen-activated protein kinase kinase 5 reviewed Kinase MAP2K5 Inhibition '=' 86 %
Q99759 BXGT019960 Mitogen-activated protein kinase kinase kinase 3 reviewed Kinase MAP3K3 Inhibition '=' -15 %
Q99683 BXGT019947 Mitogen-activated protein kinase kinase kinase 5 reviewed Kinase MAP3K5 Inhibition '=' -11 %
Q9P0L2 BXGT021289 Serine/threonine-protein kinase MARK1 reviewed Kinase MARK1 Inhibition '=' -23 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Inhibition '=' 65 %
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 reviewed Kinase MAP2K2 Inhibition '=' 95 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 IC50 '=' 2 nM
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase reviewed Kinase RAF1 Inhibition '=' 66 %
Q8NEB9 BXGT018553 Phosphatidylinositol 3-kinase catalytic subunit type 3 reviewed Kinase PIK3C3 Inhibition '=' 15 %
Q9Y2I7 BXGT026142 1-phosphatidylinositol 3-phosphate 5-kinase reviewed Kinase PIKFYVE Inhibition '=' 64 %
P49773 BXGT010741 Histidine triad nucleotide-binding protein 1 reviewed Enzyme HINT1 Inhibition '=' -16 %
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Inhibition '=' 66 %
Q9UKI8 BXGT021743 Serine/threonine-protein kinase tousled-like 1 reviewed Kinase TLK1 Inhibition '=' 19 %
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 reviewed Kinase PRKAA2 Inhibition '=' 33 %
Q96PY6 BXGT019712 Serine/threonine-protein kinase Nek1 reviewed Kinase NEK1 Inhibition '=' -11 %
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 reviewed Kinase FLT4 Activity '=' 0 %
Q9NSY1 BXGT021209 BMP-2-inducible protein kinase reviewed Kinase BMP2K Activity '=' 3 %
Q9Y6R4 BXGT022340 Mitogen-activated protein kinase kinase kinase 4 reviewed Kinase MAP3K4 Inhibition '=' 17 %
Q7KZI7 BXGT016990 Serine/threonine-protein kinase MARK2 reviewed Kinase MARK2 Inhibition '=' -8 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 Activity '=' 3 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 Activity '=' 58 %
Q9UBF8 BXGT021653 Phosphatidylinositol 4-kinase beta reviewed Kinase PI4KB Inhibition '=' 21 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Inhibition '=' 54 %
Q04771 BXGT012783 Activin receptor type-1 reviewed Kinase ACVR1 Activity '=' 21 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 IC50 '=' 5 nM
Q8WXI2 BXGT026145 Connector enhancer of kinase suppressor of ras 2 reviewed - CNKSR2 Inhibition '=' -10 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Inhibition '=' 89 %
Q8NB16 BXGT018535 Mixed lineage kinase domain-like protein reviewed Kinase MLKL Inhibition '=' 56 %
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 reviewed Kinase TBK1 Inhibition '=' -25 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Activity '=' 0 %
Q8IVT5 BXGT026146 Kinase suppressor of Ras 1 reviewed Kinase KSR1 Inhibition '=' -10 %
Q00537 BXGT012536 Cyclin-dependent kinase 17 reviewed Kinase CDK17 Inhibition '=' 21 %
Q7RTN6 BXGT017085 STE20-related kinase adapter protein alpha reviewed Kinase STRADA Inhibition '=' -47 %
Q14012 BXGT013437 Calcium/calmodulin-dependent protein kinase type 1 reviewed Kinase CAMK1 Inhibition '=' -36 %
Q9NYL2 BXGT021259 Mitogen-activated protein kinase kinase kinase 20 reviewed Kinase MAP3K20 Inhibition '=' 87 %
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 reviewed Kinase FLT4 Activity '=' 8 %
P57078 BXGT011211 Receptor-interacting serine/threonine-protein kinase 4 reviewed Kinase RIPK4 Inhibition '=' -44 %
P49336 BXGT010697 Cyclin-dependent kinase 8 reviewed Kinase CDK8 Inhibition '=' -21 %
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 reviewed Kinase MAP2K4 Activity '=' 0 %
Q96S44 BXGT019738 EKC/KEOPS complex subunit TP53RK reviewed Kinase TP53RK Inhibition '=' 46 %
Q9C0K7 BXGT026148 STE20-related kinase adapter protein beta reviewed Kinase STRADB Inhibition '=' 24 %
Q13043 BXGT013307 Serine/threonine-protein kinase 4 reviewed Kinase STK4 Inhibition '=' -4 %
O00506 BXGT003932 Serine/threonine-protein kinase 25 reviewed Kinase STK25 Inhibition '=' -29 %
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 reviewed Kinase WNK1 Inhibition '=' -21 %
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 '=' 738 nM
P29323 BXGT009334 Ephrin type-B receptor 2 reviewed Kinase EPHB2 Inhibition '=' 24 %
Q96Q40 BXGT019714 Cyclin-dependent kinase 15 reviewed Kinase CDK15 Inhibition '=' 31 %
P33981 BXGT009744 Dual specificity protein kinase TTK reviewed Kinase TTK Inhibition '=' 32 %
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Activity '=' 16 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Inhibition '=' 3 %
O15111 BXGT004126 Inhibitor of nuclear factor kappa-B kinase subunit alpha reviewed Kinase CHUK Inhibition '=' -17 %
P45984 BXGT010495 Mitogen-activated protein kinase 9 reviewed Kinase MAPK9 Inhibition '=' -14 %
Q13043 BXGT013307 Serine/threonine-protein kinase 4 reviewed Kinase STK4 Inhibition '=' -25 %
P19525 BXGT008492 Interferon-induced, double-stranded RNA-activated protein kinase reviewed Kinase EIF2AK2 Inhibition '=' -6 %
Q13188 BXGT013324 Serine/threonine-protein kinase 3 reviewed Kinase STK3 Inhibition '=' -25 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Inhibition '=' 85 %
Q8TD19 BXGT018804 Serine/threonine-protein kinase Nek9 reviewed Kinase NEK9 Inhibition '=' 24 %
Q15349 BXGT013558 Ribosomal protein S6 kinase alpha-2 reviewed Kinase RPS6KA2 Inhibition '=' 65 %
P37173 BXGT009970 TGF-beta receptor type-2 reviewed Kinase TGFBR2 Activity '=' 3 %
O00418 BXGT003918 Eukaryotic elongation factor 2 kinase reviewed Kinase EEF2K Inhibition '=' -7 %
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Inhibition '=' 21 %
Q9Y4K4 BXGT022282 Mitogen-activated protein kinase kinase kinase kinase 5 reviewed Kinase MAP4K5 Inhibition '=' -11 %
Q8TBX8 BXGT018791 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma reviewed Kinase PIP4K2C Inhibition '=' 16 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Inhibition '=' 6 %
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 reviewed Kinase STK11 Inhibition '=' -45 %
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 reviewed Kinase MAP2K2 Inhibition '=' 85 %
P07948 BXGT006702 Tyrosine-protein kinase Lyn reviewed Kinase LYN Inhibition '=' -5 %
O14730 BXGT004085 Serine/threonine-protein kinase RIO3 reviewed Kinase RIOK3 Activity '=' 0 %
P10398 BXGT007564 Serine/threonine-protein kinase A-Raf reviewed Kinase ARAF Inhibition '=' 85 %
Q14004 BXGT013435 Cyclin-dependent kinase 13 reviewed Kinase CDK13 Inhibition '=' -24 %
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Inhibition '=' 40 %
Q9NYV4 BXGT021262 Cyclin-dependent kinase 12 reviewed Kinase CDK12 Inhibition '=' -61 %
Q9Y2U5 BXGT022248 Mitogen-activated protein kinase kinase kinase 2 reviewed Kinase MAP3K2 Inhibition '=' -20 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Inhibition '=' -14 %
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Inhibition '=' -17 %
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 Activity '=' 0 %
O14730 BXGT004085 Serine/threonine-protein kinase RIO3 reviewed Kinase RIOK3 Activity '=' 74 %
Q9NYL2 BXGT021259 Mitogen-activated protein kinase kinase kinase 20 reviewed Kinase MAP3K20 Activity '=' 5 %
Q9BZL6 BXGT020199 Serine/threonine-protein kinase D2 reviewed Kinase PRKD2 Activity '=' 72 %
Q9UQB9 BXGT021810 Aurora kinase C reviewed Kinase AURKC Inhibition '=' 55 %
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 reviewed Kinase KDR Activity '=' 78 %
Q8IU85 BXGT018333 Calcium/calmodulin-dependent protein kinase type 1D reviewed Kinase CAMK1D Inhibition '=' -105 %
P07333 BXGT006602 Macrophage colony-stimulating factor 1 receptor reviewed Kinase CSF1R Inhibition '=' 18 %
Q9NRM7 BXGT021190 Serine/threonine-protein kinase LATS2 reviewed Kinase LATS2 Inhibition '=' 0 %
Q07002 BXGT012908 Cyclin-dependent kinase 18 reviewed Kinase CDK18 Inhibition '=' -6 %
O43172 BXGT026158 U4/U6 small nuclear ribonucleoprotein Prp4 reviewed Nucleic acid binding PRPF4 Inhibition '=' 15 %
Q96SB4 BXGT019740 SRSF protein kinase 1 reviewed Kinase SRPK1 Inhibition '=' -22 %
P43405 BXGT010386 Tyrosine-protein kinase SYK reviewed Kinase SYK Inhibition '=' -10 %
Q9P2K8 BXGT021302 eIF-2-alpha kinase GCN2 reviewed - EIF2AK4 Inhibition '=' -6 %
P49840 BXGT010749 Glycogen synthase kinase-3 alpha reviewed Kinase GSK3A Inhibition '=' 4 %
O94804 BXGT005334 Serine/threonine-protein kinase 10 reviewed Kinase STK10 Inhibition '=' 21 %
Q9UL54 BXGT021755 Serine/threonine-protein kinase TAO2 reviewed Kinase TAOK2 Inhibition '=' -2 %
Q9UKE5 BXGT021741 TRAF2 and NCK-interacting protein kinase reviewed Kinase TNIK Inhibition '=' 15 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03980 Curcuma aromatica Curcuma aromatica Medicinal Plant
BXGF05274 Lilium lancifolium Lilium lancifolium Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease