Showing entry for Gamma-secretase subunit PEN-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021268
Protein NameGamma-secretase subunit PEN-2
Uniport IdQ9NZ42
GenePSENEN
Gene Id55851
DomainPEN-2
Pfam PF10251  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04330 Notch signaling pathway
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034205 amyloid-beta formation
Biological Process GO:0042987 amyloid precursor protein catabolic process
Biological Process GO:0042982 amyloid precursor protein metabolic process
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0006509 membrane protein ectodomain proteolysis
Biological Process GO:0031293 membrane protein intracellular domain proteolysis
Biological Process GO:0007220 Notch receptor processing
Biological Process GO:0035333 Notch receptor processing, ligand-dependent
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0043085 positive regulation of catalytic activity
Biological Process GO:0010950 positive regulation of endopeptidase activity
Biological Process GO:0016485 protein processing
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0010008 endosome membrane
cellular component GO:0070765 gamma-secretase complex
cellular component GO:0005794 Golgi apparatus
cellular component GO:0032580 Golgi cisterna membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1236394 Signaling by ERBB4
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1266738 Developmental Biology
R-HSA-157118 Signaling by NOTCH
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-193692 Regulated proteolysis of p75NTR
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-1980143 Signaling by NOTCH1
R-HSA-1980145 Signaling by NOTCH2
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-205043 NRIF signals cell death from the nucleus
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-392499 Metabolism of proteins
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-73887 Death Receptor Signalling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9012852 Signaling by NOTCH3
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9013694 Signaling by NOTCH4
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9017802 Noncanonical activation of NOTCH3
R-HSA-9675108 Nervous system development
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0162836 BXGD003990 Hidradenitis Suppurativa Infections; Skin and Connective Tissue Diseases
C0221228 BXGD004412 Comedone Skin and Connective Tissue Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0263006 BXGD005279 Perifolliculitis
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0334013 BXGD006978 Phrynoderma Skin and Connective Tissue Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0596887 BXGD009648 mathematical ability
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1840560 BXGD014477 Hidradenitis suppurativa, familial Infections; Skin and Connective Tissue Diseases
C3151037 BXGD018374 ACNE INVERSA, FAMILIAL, 2, WITH OR WITHOUT DOWLING-DEGOS DISEASE
C3714534 BXGD019411 dowling-degos disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4021957 BXGD020840 Recurrent cutaneous abscess formation
C4023521 BXGD021209 Chronic furunculosis
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000663 Papain 206.28
BXGC0021052 Uscharin 587.26
BXGC0033727 Calotropin 532.27
BXGC0043920 Ursocholanic Acid 360.3
BXGC0052647 Asclepin 574.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein