adisease

Showing entry for Drug abuse

General Disease Information
BXGD Id	BXGD000801
Disease Name	Drug abuse
Disease CUI Id	C0013146
MeSH Codes	C25 F03
Disease Class Name	Chemically-Induced Disorders; Mental Disorders
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:150
Disease Ontology Class Name	disease of mental health
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
A1Z1Q3	BXGT001069	ADP-ribose glycohydrolase MACROD2	140733	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00519	BXGT003934	Fatty-acid amide hydrolase 1	2166	reviewed
O15439	BXGT004169	Multidrug resistance-associated protein 4	10257	reviewed	Transporter
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
O43612	BXGT004605	Orexin	3060	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75751	BXGT005150	Solute carrier family 22 member 3	6581	reviewed	Transporter
O75795	BXGT005152	UDP-glucuronosyltransferase 2B17	7367	reviewed
O94925	BXGT005342	Glutaminase kidney isoform, mitochondrial	2744	reviewed	Enzyme
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00326	BXGT005499	Alcohol dehydrogenase 1C	126	reviewed	Enzyme
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04424	BXGT006214	Argininosuccinate lyase	435	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04745	BXGT006255	Alpha-amylase 1	278	reviewed
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P05026	BXGT006296	Sodium/potassium-transporting ATPase subunit beta-1	481	reviewed	Transporter
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06276	BXGT006430	Cholinesterase	590	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	1129	reviewed	G-protein coupled receptor
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08697	BXGT006815	Alpha-2-antiplasmin	5345	reviewed	Enzyme modulator
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P10997	BXGT007643	Islet amyloid polypeptide	3375	reviewed	Signaling
P11509	BXGT007716	Cytochrome P450 2A6	1548	reviewed
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	2554	reviewed	Ion channel
P15085	BXGT008077	Carboxypeptidase A1	1357	reviewed	Enzyme
P15144	BXGT008087	Aminopeptidase N	290	reviewed	Enzyme
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15941	BXGT008176	Mucin-1	4582	reviewed
P16083	BXGT008187	Ribosyldihydronicotinamide dehydrogenase [quinone]	4835	reviewed
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	2566	reviewed	Ion channel
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21439	BXGT008649	Phosphatidylcholine translocator ABCB4	5244	reviewed	Transporter
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21583	BXGT008667	Kit ligand	4254	reviewed
P21673	BXGT008676	Diamine acetyltransferase 1	6303	reviewed
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24723	BXGT008989	Protein kinase C eta type	5583	reviewed	Kinase
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P27708	BXGT009202	CAD protein	790	reviewed	Enzyme
P28222	BXGT009238	5-hydroxytryptamine receptor 1B	3351	reviewed	G-protein coupled receptor
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28335	BXGT009255	5-hydroxytryptamine receptor 2C	3358	reviewed	G-protein coupled receptor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P30532	BXGT009433	Neuronal acetylcholine receptor subunit alpha-5	1138	reviewed	Ion channel
P30559	BXGT009442	Oxytocin receptor	5021	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31513	BXGT009546	Dimethylaniline monooxygenase [N-oxide-forming] 3	2328	reviewed	Enzyme
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P33261	BXGT009707	Cytochrome P450 2C19	1557	reviewed
P34972	BXGT009779	Cannabinoid receptor 2	1269	reviewed	G-protein coupled receptor
P34998	BXGT009781	Corticotropin-releasing factor receptor 1	1394	reviewed
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P35462	BXGT009835	D(3) dopamine receptor	1814	reviewed	G-protein coupled receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35916	BXGT009881	Vascular endothelial growth factor receptor 3	2324	reviewed	Kinase
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P41143	BXGT010223	Delta-type opioid receptor	4985	reviewed	G-protein coupled receptor
P41145	BXGT010225	Kappa-type opioid receptor	4986	reviewed	G-protein coupled receptor
P41146	BXGT010226	Nociceptin receptor	4987	reviewed	G-protein coupled receptor
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P41595	BXGT010267	5-hydroxytryptamine receptor 2B	3357	reviewed	G-protein coupled receptor
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43004	BXGT010348	Excitatory amino acid transporter 2	6506	reviewed	Transporter
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P46098	BXGT010507	5-hydroxytryptamine receptor 3A	3359	reviewed	Ion channel
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	2555	reviewed	Ion channel
P48058	BXGT010614	Glutamate receptor 4	2893	reviewed	Ion channel
P49418	BXGT010704	Amphiphysin	273	reviewed
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P49810	BXGT010747	Presenilin-2	5664	reviewed	Enzyme
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50225	BXGT010781	Sulfotransferase 1A1	6817	reviewed
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P52788	BXGT010953	Spermine synthase	6611	reviewed
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60981	BXGT011344	Destrin	11034	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
P83916	BXGT012025	Chromobox protein homolog 1	10951	reviewed	Epigenetic regulator
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q02156	BXGT012639	Protein kinase C epsilon type	5581	reviewed	Kinase
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q07157	BXGT012920	Tight junction protein ZO-1	7082	reviewed	Cell-cell junction
Q07955	BXGT012951	Serine/arginine-rich splicing factor 1	6426	reviewed	Nucleic acid binding
Q12908	BXGT013278	Ileal sodium/bile acid cotransporter	6555	reviewed	Transporter
Q13002	BXGT013303	Glutamate receptor ionotropic, kainate 2	2898	reviewed	Ion channel
Q13324	BXGT013340	Corticotropin-releasing factor receptor 2	1395	reviewed	G-protein coupled receptor
Q13451	BXGT013356	Peptidyl-prolyl cis-trans isomerase FKBP5	2289	reviewed	Enzyme
Q13554	BXGT013374	Calcium/calmodulin-dependent protein kinase type II subunit beta	816	reviewed	Kinase
Q13938	BXGT013405	Calcyphosin	828	reviewed
Q14002	BXGT013433	Carcinoembryonic antigen-related cell adhesion molecule 7	1087	reviewed
Q14123	BXGT013445	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	5137	reviewed
Q14831	BXGT013506	Metabotropic glutamate receptor 7	2917	reviewed	G-protein coupled receptor
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16512	BXGT013631	Serine/threonine-protein kinase N1	5585	reviewed	Kinase
Q16568	BXGT013640	Cocaine- and amphetamine-regulated transcript protein	9607	reviewed
Q16620	BXGT013645	BDNF/NT-3 growth factors receptor	4915	reviewed	Kinase
Q59FK2	BXGT015276	Selenocysteine lyase variant	51540	unreviewed
Q5KU26	BXGT015462	Collectin-12	81035	reviewed	Extracellular structure
Q86TM3	BXGT017607	Probable ATP-dependent RNA helicase DDX53	168400	reviewed
Q8NCC3	BXGT018546	Group XV phospholipase A2	23659	reviewed	Enzyme
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q92499	BXGT019350	ATP-dependent RNA helicase DDX1	1653	reviewed
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92831	BXGT019380	Histone acetyltransferase KAT2B	8850	reviewed
Q96I15	BXGT019674	Selenocysteine lyase	51540	reviewed	Enzyme
Q96QU1	BXGT019721	Protocadherin-15	65217	reviewed
Q96RJ0	BXGT019728	Trace amine-associated receptor 1	134864	reviewed	G-protein coupled receptor
Q99720	BXGT019955	Sigma non-opioid intracellular receptor 1	10280	reviewed
Q9BQB6	BXGT020108	Vitamin K epoxide reductase complex subunit 1	79001	reviewed	Enzyme
Q9BUB5	BXGT020133	MAP kinase-interacting serine/threonine-protein kinase 1	8569	reviewed	Kinase
Q9BX66	BXGT020158	Sorbin and SH3 domain-containing protein 1	10580	reviewed
Q9BXH1	BXGT020167	Bcl-2-binding component 3	27113	reviewed
Q9BY08	BXGT020177	Emopamil-binding protein-like	84650	reviewed	Enzyme
Q9GZQ4	BXGT020422	Neuromedin-U receptor 2	56923	reviewed	G-protein coupled receptor
Q9H227	BXGT020447	Cytosolic beta-glucosidase	57733	reviewed	Enzyme
Q9H2G2	BXGT020452	STE20-like serine/threonine-protein kinase	9748	reviewed	Kinase
Q9HBH1	BXGT020519	Peptide deformylase, mitochondrial	64146	reviewed
Q9HCC0	BXGT020530	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	64087	reviewed	Enzyme
Q9NQX4	BXGT021173	Unconventional myosin-Vc	55930	reviewed	Cellular structure
Q9NR19	BXGT021175	Acetyl-coenzyme A synthetase, cytoplasmic	55902	reviewed	Enzyme
Q9NT68	BXGT021210	Teneurin-2	57451	reviewed
Q9NVD7	BXGT021223	Alpha-parvin	55742	reviewed	Cellular structure
Q9NZ42	BXGT021268	Gamma-secretase subunit PEN-2	55851	reviewed
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UIQ6	BXGT021721	Leucyl-cystinyl aminopeptidase	4012	reviewed	Enzyme
Q9UKA9	BXGT021740	Polypyrimidine tract-binding protein 2	58155	reviewed
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9UPY5	BXGT021803	Cystine/glutamate transporter	23657	reviewed	Transporter
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
O60936	BXGT022857	Nucleolar protein 3	8996	reviewed
Q8NEU8	BXGT022976	DCC-interacting protein 13-beta	55198	reviewed
P17752	BXGT023118	Tryptophan 5-hydroxylase 1	7166	reviewed
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
P40198	BXGT023750	Carcinoembryonic antigen-related cell adhesion molecule 3	1084	reviewed
P38646	BXGT024954	Stress-70 protein, mitochondrial	3313	reviewed
Q6SZW1	BXGT025034	NAD(+) hydrolase SARM1	23098	reviewed
P27918	BXGT025485	Properdin	5199	reviewed
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
Q9BVC4	BXGT026090	Target of rapamycin complex subunit LST8	64223	reviewed
Q8N573	BXGT026157	Oxidation resistance protein 1	55074	reviewed
O43172	BXGT026158	U4/U6 small nuclear ribonucleoprotein Prp4	9128	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}