Showing entry for Disintegrin and metalloproteinase domain-containing protein 22


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021288
Protein NameDisintegrin and metalloproteinase domain-containing protein 22
Uniport IdQ9P0K1
GeneADAM22
Gene Id53616
DomainADAM_CR; Disintegrin; EGF_2; Pep_M12B_propep; Reprolysin
Pfam PF08516   PF00200   PF07974   PF01562   PF01421  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007417 central nervous system development
Biological Process GO:0022011 myelination in peripheral nervous system
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
molecular function GO:0005178 integrin binding
molecular function GO:0004222 metalloendopeptidase activity
cellular component GO:0030424 axon
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0099061 integral component of postsynaptic density membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-5682910 LGI-ADAM interactions
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007282 BXGD000458 Carotid Stenosis Nervous System Diseases; Cardiovascular Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0240379 BXGD005033 Open mouth (finding)
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0338430 BXGD007173 Limbic Encephalitis Neoplasms; Infections; Nervous System Diseases
C0391958 BXGD008020 Familial Epilepsies Nervous System Diseases
C0393682 BXGD008117 Epilepsy, Lateral Temporal Nervous System Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1609538 BXGD013444 Latent Tuberculosis Infections
C1836543 BXGD014130 Thick vermilion border
C1838062 BXGD014292 Autosomal Dominant Lateral Temporal Lobe Epilepsy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1839758 BXGD014402 Narrow forehead
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3161330 BXGD018511 Profound intellectual disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4505072 BXGD022953 Epileptic Syndromes Nervous System Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551957 BXGD023448 Epilepsy, Familial Temporal Lobe 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4553743 BXGD023548 Spasticity, CTCAE
C4693688 BXGD023611 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 61
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein