Showing entry for Ephrin type-A receptor 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021676
Protein NameEphrin type-A receptor 6
Uniport IdQ9UF33
GeneEPHA6
Gene Id285220
DomainEphA2_TM; Ephrin_lbd; fn3; Pkinase_Tyr; SAM_1
Pfam PF14575   PF01404   PF00041   PF07714   PF00536  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007411 axon guidance
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0005005 transmembrane-ephrin receptor activity
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0162635 BXGD003964 Angelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0871470 BXGD011316 Systolic Pressure
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1855179 BXGD015468 CATARACT, ANTERIOR POLAR Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3873567 BXGD019863 Peripheral neuropathy due to and following chemotherapy Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein