Showing entry for CCR4-NOT transcription complex subunit 7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021722
Protein NameCCR4-NOT transcription complex subunit 7
Uniport IdQ9UIV1
GeneCNOT7
Gene Id29883
DomainCAF1
Pfam PF04857  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03018 RNA degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033962 cytoplasmic mRNA processing body assembly
Biological Process GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
Biological Process GO:0051607 defense response to virus
Biological Process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Process GO:0043928 exonucleolytic catabolism of deadenylated mRNA
Biological Process GO:0035195 gene silencing by miRNA
Biological Process GO:0031047 gene silencing by RNA
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0060339 negative regulation of type I interferon-mediated signaling pathway
Biological Process GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0061014 positive regulation of mRNA catabolic process
Biological Process GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045070 positive regulation of viral genome replication
Biological Process GO:0042509 regulation of tyrosine phosphorylation of STAT protein
molecular function GO:0000175 3'-5'-exoribonuclease activity
molecular function GO:0004532 exoribonuclease activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004535 poly(A)-specific ribonuclease activity
molecular function GO:0003723 RNA binding
molecular function GO:0003714 transcription corepressor activity
molecular function GO:0008134 transcription factor binding
cellular component GO:0030014 CCR4-NOT complex
cellular component GO:0030015 CCR4-NOT core complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0075341 host cell PML body
cellular component GO:0016020 membrane
cellular component GO:0016604 nuclear body
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:0000932 P-body
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-429914 Deadenylation-dependent mRNA decay
R-HSA-429947 Deadenylation of mRNA
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001486 BXGD000056 Adenovirus Infections Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0023051 BXGD001602 Laryngeal Diseases Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023055 BXGD001604 Laryngeal neoplasm Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024814 BXGD001809 Marinesco-Sjogren syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025290 BXGD001852 Aseptic Meningitis Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0238288 BXGD004905 Muscular Dystrophy, Facioscapulohumeral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0553694 BXGD009409 Oropharyngeal disorders Digestive System Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686377 BXGD009834 CNS metastases Neoplasms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4523846 BXGD023079 MSI-high
C4524257 BXGD023102 MSI-low
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein