adisease

Showing entry for Male infertility

General Disease Information
BXGD Id	BXGD001500
Disease Name	Male infertility
Disease CUI Id	C0021364
MeSH Codes	C12
Disease Class Name	Male Urogenital Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000119
Human Phenotype Ontology Term	Abnormality of the genitourinary system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A6NCL1	BXGT001462	Geminin coiled-coil domain-containing protein 1	647309	reviewed
O00238	BXGT003900	Bone morphogenetic protein receptor type-1B	658	reviewed	Kinase
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O00571	BXGT003938	ATP-dependent RNA helicase DDX3X	1654	reviewed
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15297	BXGT004149	Protein phosphatase 1D	8493	reviewed	Enzyme
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60669	BXGT004891	Monocarboxylate transporter 2	9194	reviewed	Transporter
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60931	BXGT004911	Cystinosin	1497	reviewed
O75223	BXGT005106	Gamma-glutamylcyclotransferase	79017	reviewed
O76082	BXGT005175	Solute carrier family 22 member 5	6584	reviewed	Transporter
O95257	BXGT005365	Growth arrest and DNA damage-inducible protein GADD45 gamma	10912	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01148	BXGT005739	Progonadoliberin-1	2796	reviewed
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02818	BXGT005969	Osteocalcin	632	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04279	BXGT006183	Semenogelin-1	6406	reviewed
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05141	BXGT006325	ADP/ATP translocase 2	292	reviewed	Transporter
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06401	BXGT006436	Progesterone receptor	5241	reviewed	Nuclear receptor
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08758	BXGT006821	Annexin A5	308	reviewed
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P0DMV8	BXGT007509	Heat shock 70 kDa protein 1A	3304	reviewed
P0DMV9	BXGT007510	Heat shock 70 kDa protein 1B	3304	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10828	BXGT007624	Thyroid hormone receptor beta	7068	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P11586	BXGT007723	C-1-tetrahydrofolate synthase, cytoplasmic	4522	reviewed	Enzyme
P12273	BXGT007787	Prolactin-inducible protein	5304	reviewed
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15309	BXGT008105	Prostatic acid phosphatase	55	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P19784	BXGT008513	Casein kinase II subunit alpha'	1459	reviewed	Kinase
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21583	BXGT008667	Kit ligand	4254	reviewed
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22681	BXGT008795	E3 ubiquitin-protein ligase CBL	867	reviewed	Enzyme
P22749	BXGT008803	Granulysin	10578	reviewed
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23945	BXGT008931	Follicle-stimulating hormone receptor	2492	reviewed	G-protein coupled receptor
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27635	BXGT009194	60S ribosomal protein L10	6134	reviewed	Nucleic acid binding
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29372	BXGT009336	DNA-3-methyladenine glycosylase	4350	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30041	BXGT009393	Peroxiredoxin-6	9588	reviewed	Enzyme
P30044	BXGT009395	Peroxiredoxin-5, mitochondrial	25824	reviewed
P30085	BXGT009399	UMP-CMP kinase	51727	reviewed	Kinase
P30101	BXGT009402	Protein disulfide-isomerase A3	2923	reviewed
P30304	BXGT009418	M-phase inducer phosphatase 1	993	reviewed	Enzyme
P30559	BXGT009442	Oxytocin receptor	5021	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36969	BXGT009949	Phospholipid hydroperoxide glutathione peroxidase	2879	reviewed	Enzyme
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P41208	BXGT010233	Centrin-2	1069	reviewed	Calcium-binding protein
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43005	BXGT010349	Excitatory amino acid transporter 3	6505	reviewed	Transporter
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49908	BXGT010760	Selenoprotein P	6414	reviewed	Extracellular structure
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P51843	BXGT010897	Nuclear receptor subfamily 0 group B member 1	190	reviewed	Nuclear receptor
P52594	BXGT010936	Arf-GAP domain and FG repeat-containing protein 1	3267	reviewed
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54278	BXGT011038	Mismatch repair endonuclease PMS2	5395	reviewed	Nucleic acid binding
P54652	BXGT011064	Heat shock-related 70 kDa protein 2	3306	reviewed
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P55786	BXGT011125	Puromycin-sensitive aminopeptidase	9520	reviewed	Enzyme
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P63146	BXGT011504	Ubiquitin-conjugating enzyme E2 B	7320	reviewed
P78317	BXGT011831	E3 ubiquitin-protein ligase RNF4	6047	reviewed
P78396	BXGT011842	Cyclin-A1	8900	reviewed	Enzyme modulator
P78527	BXGT011846	DNA-dependent protein kinase catalytic subunit	5591	reviewed	Kinase
Q00613	BXGT012540	Heat shock factor protein 1	3297	reviewed	Transcription factor
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q01105	BXGT012569	Protein SET	6418	reviewed	Enzyme modulator
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q02790	BXGT012672	Peptidyl-prolyl cis-trans isomerase FKBP4	2288	reviewed	Enzyme
Q03933	BXGT012740	Heat shock factor protein 2	3298	reviewed	Transcription factor
Q05315	BXGT012811	Galectin-10	1178	reviewed	Signaling
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06520	BXGT012880	Bile salt sulfotransferase	6822	reviewed
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q13148	BXGT013318	TAR DNA-binding protein 43	23435	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13233	BXGT013330	Mitogen-activated protein kinase kinase kinase 1	4214	reviewed	Kinase
Q13285	BXGT013335	Steroidogenic factor 1	2516	reviewed	Nuclear receptor
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14393	BXGT013466	Growth arrest-specific protein 6	2621	reviewed	Extracellular structure
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q15493	BXGT013575	Regucalcin	9104	reviewed	Enzyme
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q58F21	BXGT015228	Bromodomain testis-specific protein	676	reviewed	Epigenetic regulator
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6P6C2	BXGT016455	RNA demethylase ALKBH5	54890	reviewed
Q7RTX0	BXGT017088	Taste receptor type 1 member 3	83756	reviewed	G-protein coupled receptor
Q8IYD8	BXGT018367	Fanconi anemia group M protein	57697	reviewed	Enzyme
Q8NHU6	BXGT018569	Tudor domain-containing protein 7	23424	reviewed	Enzyme
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92784	BXGT019373	Zinc finger protein DPF3	8110	reviewed	Enzyme
Q92959	BXGT019400	Solute carrier organic anion transporter family member 2A1	6578	reviewed	Transporter
Q96BZ9	BXGT019629	TBC1 domain family member 20	128637	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q99497	BXGT019926	Protein/nucleic acid deglycase DJ-1	11315	reviewed	Enzyme
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q9BW62	BXGT020149	Katanin p60 ATPase-containing subunit A-like 1	84056	reviewed	Cellular structure
Q9BXA7	BXGT020164	Testis-specific serine/threonine-protein kinase 1	83942	reviewed	Kinase
Q9BXT4	BXGT020175	Tudor domain-containing protein 1	56165	reviewed	Enzyme
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9H6Z4	BXGT020487	Ran-binding protein 3	8498	reviewed	Enzyme modulator
Q9HCG7	BXGT020533	Non-lysosomal glucosylceramidase	57704	reviewed
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UBK8	BXGT021655	Methionine synthase reductase	4552	reviewed
Q9UGP5	BXGT021689	DNA polymerase lambda	27343	reviewed	Enzyme
Q9UHI8	BXGT021701	A disintegrin and metalloproteinase with thrombospondin motifs 1	9510	reviewed	Enzyme
Q9UHL0	BXGT021702	ATP-dependent RNA helicase DDX25	29118	reviewed
Q9UIV1	BXGT021722	CCR4-NOT transcription complex subunit 7	29883	reviewed	Transcription factor
Q9UJW3	BXGT021732	DNA (cytosine-5)-methyltransferase 3-like	29947	reviewed
Q9UNA0	BXGT021784	A disintegrin and metalloproteinase with thrombospondin motifs 5	11096	reviewed	Enzyme
Q9UPY3	BXGT021802	Endoribonuclease Dicer	23405	reviewed	Enzyme
Q9UQB9	BXGT021810	Aurora kinase C	6795	reviewed	Kinase
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q9Y6E0	BXGT022327	Serine/threonine-protein kinase 24	8428	reviewed	Kinase
Q9Y6F8	BXGT022329	Testis-specific chromodomain protein Y 1	9085	reviewed
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q9NXB9	BXGT022660	Elongation of very long chain fatty acids protein 2	54898	reviewed	Enzyme
P36873	BXGT023107	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	5501	reviewed	Enzyme
A9YTQ3	BXGT023537	Aryl hydrocarbon receptor repressor	57491	reviewed	Transcription factor
Q5T2W1	BXGT023979	Na(+)/H(+) exchange regulatory cofactor NHE-RF3	5174	reviewed
Q8IYM1	BXGT024860	Septin-12	124404	reviewed	Enzyme modulator
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q9NRR4	BXGT025788	Ribonuclease 3	29102	reviewed	Enzyme
Q8N122	BXGT026091	Regulatory-associated protein of mTOR	57521	reviewed
P07320	BXGT026150	Gamma-crystallin D	1421	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}