Showing entry for Laryngeal Squamous Cell Carcinoma


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD006740
Disease NameLaryngeal Squamous Cell Carcinoma
Disease CUI IdC0280324
MeSH Codes C04   C08   C09  
Disease Class NameNeoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00469 BXGT003926 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 5352 reviewed Enzyme
O14727 BXGT004084 Apoptotic protease-activating factor 1 317 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 1111 reviewed Kinase
O14763 BXGT004093 Tumor necrosis factor receptor superfamily member 10B 8795 reviewed
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O15151 BXGT004132 Protein Mdm4 4194 reviewed Nucleic acid binding
O15197 BXGT004136 Ephrin type-B receptor 6 2051 reviewed Kinase
O15357 BXGT004156 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 3636 reviewed
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 5170 reviewed Kinase
O43157 BXGT004572 Plexin-B1 5364 reviewed
O60427 BXGT004875 Acyl-CoA (8-3)-desaturase 3992 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O60882 BXGT004905 Matrix metalloproteinase-20 9313 reviewed Enzyme
O75173 BXGT005105 A disintegrin and metalloproteinase with thrombospondin motifs 4 9507 reviewed Enzyme
O75496 BXGT005132 Geminin 51053 reviewed
O95067 BXGT005347 G2/mitotic-specific cyclin-B2 9133 reviewed Enzyme modulator
O95864 BXGT005403 Acyl-CoA 6-desaturase 9415 reviewed
P00325 BXGT005498 Alcohol dehydrogenase 1B 125 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P02511 BXGT005885 Alpha-crystallin B chain 1410 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04083 BXGT006147 Annexin A1 301 reviewed
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04731 BXGT006251 Metallothionein-1A 4489 reviewed
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P04733 BXGT006253 Metallothionein-1F 4494 reviewed
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05230 BXGT006344 Fibroblast growth factor 1 2246 reviewed Signaling
P06493 BXGT006445 Cyclin-dependent kinase 1 983 reviewed Kinase
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P07203 BXGT006566 Glutathione peroxidase 1 2876 reviewed Enzyme
P07438 BXGT006625 Metallothionein-1B 4490 reviewed
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08670 BXGT006810 Vimentin 7431 reviewed
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08758 BXGT006821 Annexin A5 308 reviewed
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09238 BXGT006875 Stromelysin-2 4319 reviewed Enzyme
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09960 BXGT006952 Leukotriene A-4 hydrolase 4048 reviewed
P10276 BXGT007553 Retinoic acid receptor alpha 5914 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10646 BXGT007598 Tissue factor pathway inhibitor 7035 reviewed Enzyme modulator
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12830 BXGT007852 Cadherin-1 999 reviewed
P13640 BXGT007935 Metallothionein-1G 4495 reviewed
P13688 BXGT007943 Carcinoembryonic antigen-related cell adhesion molecule 1 634 reviewed
P14621 BXGT008028 Acylphosphatase-2 98 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14921 BXGT008068 Protein C-ets-1 2113 reviewed Transcription factor
P15311 BXGT008106 Ezrin 7430 reviewed Cellular structure
P15531 BXGT008136 Nucleoside diphosphate kinase A 4830 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16070 BXGT008186 CD44 antigen 960 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16471 BXGT008233 Prolactin receptor 5618 reviewed Signaling
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P20815 BXGT008604 Cytochrome P450 3A5 1577 reviewed Enzyme
P21266 BXGT008632 Glutathione S-transferase Mu 3 2947 reviewed
P21333 BXGT008638 Filamin-A 2316 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P22033 BXGT008721 Methylmalonyl-CoA mutase, mitochondrial 4594 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 54658 reviewed
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P22894 BXGT008815 Neutrophil collagenase 4317 reviewed Enzyme
P23468 BXGT008870 Receptor-type tyrosine-protein phosphatase delta 5789 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P30281 BXGT009416 G1/S-specific cyclin-D3 896 reviewed Enzyme modulator
P30291 BXGT009417 Wee1-like protein kinase 7465 reviewed Kinase
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P30874 BXGT009475 Somatostatin receptor type 2 6752 reviewed G-protein coupled receptor
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P33991 BXGT009745 DNA replication licensing factor MCM4 4173 reviewed Enzyme
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35346 BXGT009813 Somatostatin receptor type 5 6755 reviewed G-protein coupled receptor
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36551 BXGT009927 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 1371 reviewed Enzyme
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P43405 BXGT010386 Tyrosine-protein kinase SYK 6850 reviewed Kinase
P45452 BXGT010462 Collagenase 3 4322 reviewed Enzyme
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 6416 reviewed Kinase
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P46940 BXGT010556 Ras GTPase-activating-like protein IQGAP1 8826 reviewed Enzyme modulator
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48039 BXGT010607 Melatonin receptor type 1A 4543 reviewed G-protein coupled receptor
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49023 BXGT010672 Paxillin 5829 reviewed Cellular structure
P49336 BXGT010697 Cyclin-dependent kinase 8 1024 reviewed Kinase
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P52789 BXGT010954 Hexokinase-2 3099 reviewed Kinase
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P55774 BXGT011124 C-C motif chemokine 18 6362 reviewed Signaling
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P62508 BXGT011431 Estrogen-related receptor gamma 2104 reviewed Nuclear receptor
P78396 BXGT011842 Cyclin-A1 8900 reviewed Enzyme modulator
P78527 BXGT011846 DNA-dependent protein kinase catalytic subunit 5591 reviewed Kinase
P80294 BXGT011890 Metallothionein-1H 4496 reviewed
P80297 BXGT011891 Metallothionein-1X 4501 reviewed
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 8140 reviewed Transporter
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q04912 BXGT012790 Macrophage-stimulating protein receptor 4486 reviewed Kinase
Q05397 BXGT012815 Focal adhesion kinase 1 5747 reviewed Kinase
Q07108 BXGT012919 Early activation antigen CD69 969 reviewed
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q08722 BXGT013002 Leukocyte surface antigen CD47 961 reviewed
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13009 BXGT013305 T-lymphoma invasion and metastasis-inducing protein 1 7074 reviewed
Q13126 BXGT013313 S-methyl-5'-thioadenosine phosphorylase 4507 reviewed Enzyme
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q13427 BXGT013354 Peptidyl-prolyl cis-trans isomerase G 9360 reviewed
Q13464 BXGT013357 Rho-associated protein kinase 1 6093 reviewed Kinase
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13563 BXGT013377 Polycystin-2 5311 reviewed Ion channel
Q13625 BXGT013384 Apoptosis-stimulating of p53 protein 2 7159 reviewed Enzyme modulator
Q14571 BXGT013485 Inositol 1,4,5-trisphosphate receptor type 2 3709 reviewed Ion channel
Q14676 BXGT013497 Mediator of DNA damage checkpoint protein 1 9656 reviewed
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 5163 reviewed Kinase
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15375 BXGT013562 Ephrin type-A receptor 7 2045 reviewed Kinase
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle 4638 reviewed Kinase
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16658 BXGT013651 Fascin 6624 reviewed Cellular structure
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q59FK2 BXGT015276 Selenocysteine lyase variant 51540 unreviewed
Q8N339 BXGT018503 Metallothionein-1M 4499 reviewed
Q8NBS9 BXGT018543 Thioredoxin domain-containing protein 5 81567 reviewed
Q8WWY3 BXGT019006 U4/U6 small nuclear ribonucleoprotein Prp31 26121 reviewed Nucleic acid binding
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96I15 BXGT019674 Selenocysteine lyase 51540 reviewed Enzyme
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96T88 BXGT019747 E3 ubiquitin-protein ligase UHRF1 29128 reviewed
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 11315 reviewed Enzyme
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 2852 reviewed G-protein coupled receptor
Q99962 BXGT019978 Endophilin-A1 6456 reviewed
Q9BUD6 BXGT020134 Spondin-2 10417 reviewed Extracellular structure
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9NYY3 BXGT021264 Serine/threonine-protein kinase PLK2 10769 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UIV1 BXGT021722 CCR4-NOT transcription complex subunit 7 29883 reviewed Transcription factor
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNA0 BXGT021784 A disintegrin and metalloproteinase with thrombospondin motifs 5 11096 reviewed Enzyme
Q9UPY5 BXGT021803 Cystine/glutamate transporter 23657 reviewed Transporter
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y4I1 BXGT022278 Unconventional myosin-Va 4644 reviewed Cellular structure
Q9Y5K2 BXGT022293 Kallikrein-4 9622 reviewed Enzyme
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q13330 BXGT023103 Metastasis-associated protein MTA1 9112 reviewed Nucleic acid binding
P19875 BXGT023294 C-X-C motif chemokine 2 2920 reviewed Signaling
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
Q86SF2 BXGT024390 N-acetylgalactosaminyltransferase 7 51809 reviewed Enzyme
Q9H0M0 BXGT024419 NEDD4-like E3 ubiquitin-protein ligase WWP1 11059 reviewed Enzyme
P21926 BXGT024578 CD9 antigen 928 reviewed
O14917 BXGT025818 Protocadherin-17 27253 reviewed
P33993 BXGT025970 DNA replication licensing factor MCM7 4176 reviewed Enzyme
Q96JB6 BXGT026118 Lysyl oxidase homolog 4 84171 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
Q08477 BXGT026164 Docosahexaenoic acid omega-hydroxylase CYP4F3 4051 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease