Showing entry for Malignant neoplasm of larynx


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD000428
Disease NameMalignant neoplasm of larynx
Disease CUI IdC0007107
MeSH Codes C04   C08   C09  
Disease Class NameNeoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00469 BXGT003926 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 5352 reviewed Enzyme
O14727 BXGT004084 Apoptotic protease-activating factor 1 317 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15294 BXGT004147 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 8473 reviewed
O15357 BXGT004156 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 3636 reviewed
O15527 BXGT004176 N-glycosylase/DNA lyase 4968 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O94762 BXGT005329 ATP-dependent DNA helicase Q5 9400 reviewed Enzyme
O95819 BXGT005398 Mitogen-activated protein kinase kinase kinase kinase 4 9448 reviewed Kinase
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00325 BXGT005498 Alcohol dehydrogenase 1B 125 reviewed Enzyme
P00326 BXGT005499 Alcohol dehydrogenase 1C 126 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01275 BXGT005747 Glucagon 2641 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P02795 BXGT005968 Metallothionein-2 4502 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04083 BXGT006147 Annexin A1 301 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04731 BXGT006251 Metallothionein-1A 4489 reviewed
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P04733 BXGT006253 Metallothionein-1F 4494 reviewed
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05161 BXGT006331 Ubiquitin-like protein ISG15 9636 reviewed Nucleic acid binding
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05556 BXGT006368 Integrin beta-1 3688 reviewed Receptor
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P07099 BXGT006546 Epoxide hydrolase 1 2052 reviewed
P07203 BXGT006566 Glutathione peroxidase 1 2876 reviewed Enzyme
P07355 BXGT006609 Annexin A2 302 reviewed
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P07438 BXGT006625 Metallothionein-1B 4490 reviewed
P07858 BXGT006689 Cathepsin B 1508 reviewed Enzyme
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08195 BXGT006745 4F2 cell-surface antigen heavy chain 6520 reviewed Transporter
P08758 BXGT006821 Annexin A5 308 reviewed
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09455 BXGT006890 Retinol-binding protein 1 5947 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P0DP23 BXGT007520 Calmodulin-1 808 reviewed
P0DP24 BXGT007521 Calmodulin-2 808 reviewed
P10144 BXGT007541 Granzyme B 3002 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10600 BXGT007584 Transforming growth factor beta-3 proprotein 7043 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11169 BXGT007664 Solute carrier family 2, facilitated glucose transporter member 3 6515 reviewed Transporter
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11766 BXGT007745 Alcohol dehydrogenase class-3 128 reviewed Enzyme
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P13640 BXGT007935 Metallothionein-1G 4495 reviewed
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 10327 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15531 BXGT008136 Nucleoside diphosphate kinase A 4830 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18440 BXGT008404 Arylamine N-acetyltransferase 1 9 reviewed Enzyme
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P20810 BXGT008602 Calpastatin 831 reviewed
P21266 BXGT008632 Glutathione S-transferase Mu 3 2947 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 54658 reviewed
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P22894 BXGT008815 Neutrophil collagenase 4317 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha 5295 reviewed Kinase
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P29034 BXGT009309 Protein S100-A2 6273 reviewed Calcium-binding protein
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30101 BXGT009402 Protein disulfide-isomerase A3 2923 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40394 BXGT010178 Alcohol dehydrogenase class 4 mu/sigma chain 131 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43405 BXGT010386 Tyrosine-protein kinase SYK 6850 reviewed Kinase
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46063 BXGT010501 ATP-dependent DNA helicase Q1 5965 reviewed Enzyme
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48039 BXGT010607 Melatonin receptor type 1A 4543 reviewed G-protein coupled receptor
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P49959 BXGT010766 Double-strand break repair protein MRE11 4361 reviewed
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P52789 BXGT010954 Hexokinase-2 3099 reviewed Kinase
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P55055 BXGT011101 Oxysterols receptor LXR-beta 7376 reviewed Nuclear receptor
P58004 BXGT011222 Sestrin-2 83667 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62826 BXGT011463 GTP-binding nuclear protein Ran 5901 reviewed Enzyme modulator
P78504 BXGT011844 Protein jagged-1 182 reviewed
P78556 BXGT011849 C-C motif chemokine 20 6364 reviewed Signaling
P80294 BXGT011890 Metallothionein-1H 4496 reviewed
P80297 BXGT011891 Metallothionein-1X 4501 reviewed
Q01453 BXGT012588 Peripheral myelin protein 22 5376 reviewed Cellular structure
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 8140 reviewed Transporter
Q01831 BXGT012621 DNA repair protein complementing XP-C cells 7508 reviewed Nucleic acid binding
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q03468 BXGT012716 DNA excision repair protein ERCC-6 2074 reviewed
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q05397 BXGT012815 Focal adhesion kinase 1 5747 reviewed Kinase
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q12794 BXGT013265 Hyaluronidase-1 3373 reviewed Enzyme
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 3757 reviewed Ion channel
Q13085 BXGT013309 Acetyl-CoA carboxylase 1 31 reviewed
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13887 BXGT013401 Krueppel-like factor 5 688 reviewed Nucleic acid binding
Q14289 BXGT013459 Protein-tyrosine kinase 2-beta 2185 reviewed Kinase
Q15139 BXGT013546 Serine/threonine-protein kinase D1 5587 reviewed Kinase
Q15375 BXGT013562 Ephrin type-A receptor 7 2045 reviewed Kinase
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15942 BXGT013613 Zyxin 7791 reviewed Enzyme modulator
Q16620 BXGT013645 BDNF/NT-3 growth factors receptor 4915 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16678 BXGT013656 Cytochrome P450 1B1 1545 reviewed Enzyme
Q16836 BXGT013679 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 3033 reviewed
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q86TM3 BXGT017607 Probable ATP-dependent RNA helicase DDX53 168400 reviewed
Q8N339 BXGT018503 Metallothionein-1M 4499 reviewed
Q8NCC3 BXGT018546 Group XV phospholipase A2 23659 reviewed Enzyme
Q8TCG1 BXGT018797 Protein CIP2A 57650 reviewed
Q8WWY3 BXGT019006 U4/U6 small nuclear ribonucleoprotein Prp31 26121 reviewed Nucleic acid binding
Q92547 BXGT019355 DNA topoisomerase 2-binding protein 1 11073 reviewed
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96PD4 BXGT019705 Interleukin-17F 112744 reviewed
Q99707 BXGT019952 Methionine synthase 4548 reviewed
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 54577 reviewed
Q9HC29 BXGT020526 Nucleotide-binding oligomerization domain-containing protein 2 64127 reviewed Enzyme
Q9NR12 BXGT021174 PDZ and LIM domain protein 7 9260 reviewed Cellular structure
Q9NR19 BXGT021175 Acetyl-coenzyme A synthetase, cytoplasmic 55902 reviewed Enzyme
Q9NYY3 BXGT021264 Serine/threonine-protein kinase PLK2 10769 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UBE8 BXGT021652 Serine/threonine-protein kinase NLK 51701 reviewed Kinase
Q9UIV1 BXGT021722 CCR4-NOT transcription complex subunit 7 29883 reviewed Transcription factor
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q9UPY5 BXGT021803 Cystine/glutamate transporter 23657 reviewed Transporter
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y3D8 BXGT022258 Adenylate kinase isoenzyme 6 102157402 reviewed
Q92878 BXGT023071 DNA repair protein RAD50 10111 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q59FF6 BXGT023693 Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant 2074 unreviewed
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
P0DP25 BXGT024595 Calmodulin-3 808 reviewed
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
P28715 BXGT025675 DNA repair protein complementing XP-G cells 2073 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease