Showing entry for Brefeldin A-inhibited guanine nucleotide-exchange protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022326
Protein NameBrefeldin A-inhibited guanine nucleotide-exchange protein 1
Uniport IdQ9Y6D6
GeneARFGEF1
Gene Id10565
DomainDCB; DUF1981; Sec7; Sec7_N
Pfam PF16213   PF09324   PF01369   PF12783  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0010256 endomembrane system organization
Biological Process GO:0006887 exocytosis
Biological Process GO:0007030 Golgi organization
Biological Process GO:0030837 negative regulation of actin filament polymerization
Biological Process GO:0034260 negative regulation of GTPase activity
Biological Process GO:0031175 neuron projection development
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0090284 positive regulation of protein glycosylation in Golgi
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0090303 positive regulation of wound healing
Biological Process GO:0015031 protein transport
Biological Process GO:0032012 regulation of ARF protein signal transduction
Biological Process GO:2000114 regulation of establishment of cell polarity
molecular function GO:0005086 ARF guanyl-nucleotide exchange factor activity
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0017022 myosin binding
molecular function GO:0034237 protein kinase A regulatory subunit binding
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0016363 nuclear matrix
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0030532 small nuclear ribonucleoprotein complex
cellular component GO:0005802 trans-Golgi network
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035920 BXGD002570 Rubella Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0149530 BXGD003330 Congenital heart block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0205682 BXGD004105 Waist-Hip Ratio
C0238111 BXGD004877 Lennox-Gastaut syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1136033 BXGD011703 Cutaneous Mastocytosis Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2986665 BXGD018237 Early-Stage Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C3810212 BXGD019642 JOUBERT SYNDROME 21
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein