Showing entry for Diacylglycerol kinase theta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022672
Protein NameDiacylglycerol kinase theta
Uniport IdP52824
GeneDGKQ
Gene Id1609
DomainC1_1; DAGK_acc; DAGK_cat; RA
Pfam PF00130   PF00609   PF00781   PF00788  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00561 Glycerolipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0046339 diacylglycerol metabolic process
Biological Process GO:0046486 glycerolipid metabolic process
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0046834 lipid phosphorylation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0010801 negative regulation of peptidyl-threonine phosphorylation
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0006654 phosphatidic acid biosynthetic process
Biological Process GO:0030168 platelet activation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0070528 protein kinase C signaling
Biological Process GO:0090181 regulation of cholesterol metabolic process
Biological Process GO:2000064 regulation of cortisol biosynthetic process
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0008277 regulation of G protein-coupled receptor signaling pathway
Biological Process GO:2000182 regulation of progesterone biosynthetic process
Biological Process GO:1903432 regulation of TORC1 signaling
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0033198 response to ATP
Biological Process GO:0051591 response to cAMP
Biological Process GO:0070493 thrombin-activated receptor signaling pathway
molecular function GO:0033613 activating transcription factor binding
molecular function GO:0005524 ATP binding
molecular function GO:0004143 diacylglycerol kinase activity
molecular function GO:0019900 kinase binding
molecular function GO:0046872 metal ion binding
molecular function GO:0003951 NAD+ kinase activity
molecular function GO:0043274 phospholipase binding
molecular function GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0005768 endosome
cellular component GO:0016363 nuclear matrix
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-76002 Platelet activation, signaling and aggregation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0086981 BXGD003317 Sicca Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0205682 BXGD004105 Waist-Hip Ratio
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0751772 BXGD010583 REM Sleep Behavior Disorder Nervous System Diseases; Mental Disorders
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C2985280 BXGD018223 Blood Protein Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0037274 (+)-Alpha-Tocopheryl Succinate 530.4
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein