Showing entry for Replicase polyprotein 1ab


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023328
Protein NameReplicase polyprotein 1ab
Uniport IdP0DTD1
Generep
Gene Id43740578
Domain-
Pfam PF16348   PF06478   PF12379   PF01661   PF16251   PF11501   PF09401   PF06471   PF06460   PF12124   PF08716   PF08717   PF08710   PF05409   PF11633   PF08715  
OrganismSevere acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0039595 induction by virus of catabolism of host mRNA
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0032259 methylation
Biological Process GO:0039519 modulation by virus of host autophagy
Biological Process GO:0039648 modulation by virus of host protein ubiquitination
Biological Process GO:0080009 mRNA methylation
Biological Process GO:0039690 positive stranded viral RNA replication
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0070536 protein K63-linked deubiquitination
Biological Process GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Biological Process GO:0039548 suppression by virus of host IRF3 activity
Biological Process GO:0039579 suppression by virus of host ISG15 activity
Biological Process GO:0039644 suppression by virus of host NF-kappaB transcription factor activity
Biological Process GO:0039722 suppression by virus of host toll-like receptor signaling pathway
Biological Process GO:0039547 suppression by virus of host TRAF activity
Biological Process GO:0039604 suppression by virus of host translation
Biological Process GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
Biological Process GO:0039501 suppression by virus of host type I interferon production
Biological Process GO:0006351 transcription, DNA-templated
Biological Process GO:0001172 transcription, RNA-templated
Biological Process GO:0019079 viral genome replication
Biological Process GO:0019082 viral protein processing
Biological Process GO:0039694 viral RNA genome replication
Biological Process GO:0019083 viral transcription
molecular function GO:0000175 3'-5'-exoribonuclease activity
molecular function GO:0005524 ATP binding
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0008234 cysteine-type peptidase activity
molecular function GO:0003678 DNA helicase activity
molecular function GO:0004519 endonuclease activity
molecular function GO:0004527 exonuclease activity
molecular function GO:0004386 helicase activity
molecular function GO:0019785 ISG15-specific protease activity
molecular function GO:0008168 methyltransferase activity
molecular function GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
molecular function GO:0046983 protein dimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003968 RNA-directed 5'-3' RNA polymerase activity
molecular function GO:0003724 RNA helicase activity
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0039714 cytoplasmic viral factory
cellular component GO:0030430 host cell cytoplasm
cellular component GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0033644 host cell membrane
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9694271 Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
R-HSA-9694271 Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
R-HSA-9694301 Maturation of replicase proteins
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription
R-HSA-9694686 Replication of the SARS-CoV-2 genome
R-HSA-9694686 Replication of the SARS-CoV-2 genome
R-HSA-9694786 Transcription of SARS-CoV-2 sgRNAs
R-HSA-9694786 Transcription of SARS-CoV-2 sgRNAs
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003418 Undylic acid 324.18
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0005793 Baicalein 270.24
BXGC0006198 Citric acid 192.12
BXGC0006368 Formic acid 46.03
BXGC0019419 2-hydroxypyridine 95.04
BXGC0023872 Adenine 135.05
BXGC0024261 Adenosine Phosphate 347.06
BXGC0030612 tetraethylene glycol 194.12
BXGC0039904 beta-D-Fructopyranose 180.06
BXGC0045008 Oprea1_783471 247.12
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein