Showing entry for Engulfment and cell motility protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024291
Protein NameEngulfment and cell motility protein 2
Uniport IdQ96JJ3
GeneELMO2
Gene Id63916
DomainDUF3361; ELMO_CED12; PH_12
Pfam PF11841   PF04727   PF16457  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05100 Bacterial invasion of epithelial cells
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0006915 apoptotic process
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0060326 cell chemotaxis
Biological Process GO:0048870 cell motility
Biological Process GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0048365 Rac GTPase binding
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0017124 SH3 domain binding
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663205 Infectious disease
R-HSA-8848021 Signaling by PTK6
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9658195 Leishmania infection
R-HSA-9664407 Parasite infection
R-HSA-9664417 Leishmania phagocytosis
R-HSA-9664422 FCGR3A-mediated phagocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002884 BXGD000143 Hypochromic anemia Hemic and Lymphatic Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016049 BXGD001039 Fibromatosis, Gingival Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0158570 BXGD003892 Vascular anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0221766 BXGD004478 Diastasis recti Musculoskeletal Diseases; Wounds and Injuries
C0239174 BXGD004969 Late tooth eruption
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0796133 BXGD010801 Ramon Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases; Behavior and Behavior Mechanisms
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1306710 BXGD012372 Facial asymmetry Pathological Conditions, Signs and Symptoms
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1398312 BXGD012999 Narrow palate
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1847197 BXGD014856 Vascular Malformation, Primary Intraosseous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1849211 BXGD015023 Generalized hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1866231 BXGD016388 Full cheeks
C1961121 BXGD016675 Congenital vascular anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C3152182 BXGD018461 Anterior chamber anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021800 BXGD020790 Abnormality of dental enamel
C4022018 BXGD020872 Telangiectasia of the skin Cardiovascular Diseases
C4539078 BXGD023225 Supraumbilical raphe
C4553962 BXGD023553 Hyperkeratosis, CTCAE
C4721411 BXGD023735 Osteolysis Musculoskeletal Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein