adisease

Showing entry for Hyperkeratosis

General Disease Information
BXGD Id	BXGD011309
Disease Name	Hyperkeratosis
Disease CUI Id	C0870082
MeSH Codes	C23 C17
Disease Class Name	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001574
Human Phenotype Ontology Term	Abnormality of the integument
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00204	BXGT003893	Sulfotransferase family cytosolic 2B member 1	6820	reviewed
O14672	BXGT004081	Disintegrin and metalloproteinase domain-containing protein 10	102	reviewed
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O15269	BXGT004145	Serine palmitoyltransferase 1	10558	reviewed	Enzyme
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O60259	BXGT004863	Kallikrein-8	11202	reviewed	Enzyme
O94925	BXGT005342	Glutaminase kidney isoform, mitochondrial	2744	reviewed	Enzyme
O95786	BXGT005396	Probable ATP-dependent RNA helicase DDX58	23586	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02533	BXGT005887	Keratin, type I cytoskeletal 14	3861	reviewed
P02538	BXGT005888	Keratin, type II cytoskeletal 6A	3853	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02654	BXGT005911	Apolipoprotein C-I	341	reviewed
P03952	BXGT006118	Plasma kallikrein	3818	reviewed	Enzyme
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04264	BXGT006176	Keratin, type II cytoskeletal 1	3848	reviewed
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06280	BXGT006433	Alpha-galactosidase A	2717	reviewed
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P08779	BXGT006824	Keratin, type I cytoskeletal 16	3868	reviewed
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09884	BXGT006937	DNA polymerase alpha catalytic subunit	5422	reviewed
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P13645	BXGT007936	Keratin, type I cytoskeletal 10	3858	reviewed
P13647	BXGT007937	Keratin, type II cytoskeletal 5	3852	reviewed
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15924	BXGT008171	Desmoplakin	1832	reviewed	Cellular structure
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17050	BXGT008277	Alpha-N-acetylgalactosaminidase	4668	reviewed
P17735	BXGT008335	Tyrosine aminotransferase	6898	reviewed
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P21583	BXGT008667	Kit ligand	4254	reviewed
P22223	BXGT008744	Cadherin-3	1001	reviewed
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35527	BXGT009843	Keratin, type I cytoskeletal 9	3857	reviewed
P35916	BXGT009881	Vascular endothelial growth factor receptor 3	2324	reviewed	Kinase
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P49767	BXGT010739	Vascular endothelial growth factor C	7424	reviewed	Signaling
P49862	BXGT010752	Kallikrein-7	5650	reviewed	Enzyme
P53634	BXGT011007	Dipeptidyl peptidase 1	1075	reviewed	Enzyme
P78536	BXGT011847	Disintegrin and metalloproteinase domain-containing protein 17	6868	reviewed
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q13887	BXGT013401	Krueppel-like factor 5	688	reviewed	Nucleic acid binding
Q14145	BXGT013448	Kelch-like ECH-associated protein 1	9817	reviewed
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q15126	BXGT013544	Phosphomevalonate kinase	10654	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q8NET8	BXGT018557	Transient receptor potential cation channel subfamily V member 3	162514	reviewed	Ion channel
Q8WWM9	BXGT019001	Cytoglobin	114757	reviewed
Q92963	BXGT019401	GTP-binding protein Rit1	6016	reviewed	Enzyme modulator
Q96F46	BXGT019656	Interleukin-17 receptor A	23765	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q99519	BXGT019928	Sialidase-1	4758	reviewed	Enzyme
Q9C000	BXGT020206	NACHT, LRR and PYD domains-containing protein 1	22861	reviewed
Q9H8P0	BXGT020497	Polyprenol reductase	79644	reviewed
Q9UBN7	BXGT021658	Histone deacetylase 6	10013	reviewed	Epigenetic regulator
Q9Y5Y6	BXGT022308	Suppressor of tumorigenicity 14 protein	6768	reviewed	Enzyme
Q9Y6K9	BXGT022333	NF-kappa-B essential modulator	8517	reviewed	Kinase
P16615	BXGT023653	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	488	reviewed	Transporter
Q96JJ3	BXGT024291	Engulfment and cell motility protein 2	63916	reviewed	Signaling
P28715	BXGT025675	DNA repair protein complementing XP-G cells	2073	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}