Showing entry for Target of rapamycin complex subunit LST8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026090
Protein NameTarget of rapamycin complex subunit LST8
Uniport IdQ9BVC4
GeneMLST8
Gene Id64223
DomainWD40
Pfam PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04136 Autophagy - other
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032148 activation of protein kinase B activity
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0032008 positive regulation of TOR signaling
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0038202 TORC1 signaling
Biological Process GO:0031929 TOR signaling
molecular function GO:0043539 protein serine/threonine kinase activator activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0031931 TORC1 complex
cellular component GO:0031932 TORC2 complex
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-1643685 Disease
R-HSA-165159 MTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-212436 Generic Transcription Pathway
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-2262752 Cellular responses to stress
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389356 CD28 co-stimulation
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-6807070 PTEN Regulation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9612973 Autophagy
R-HSA-9639288 Amino acids regulate mTORC1
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0036916 BXGD002643 Sexually Transmitted Diseases Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0038587 BXGD002773 Substance Withdrawal Syndrome Chemically-Induced Disorders; Mental Disorders
C0042025 BXGD002950 Urinary Stress Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0349459 BXGD007907 Cervical intraepithelial neoplasia grade 2 Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002953 2-Phenethyl isothiocyanate 163.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein