Showing entry for Tyrosine-protein phosphatase non-receptor type 12


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026141
Protein NameTyrosine-protein phosphatase non-receptor type 12
Uniport IdQ05209
GenePTPN12
Gene Id5782
DomainY_phosphatase
Pfam PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0038128 ERBB2 signaling pathway
Biological Process GO:1901185 negative regulation of ERBB signaling pathway
Biological Process GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0042058 regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0042246 tissue regeneration
molecular function GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
molecular function GO:0004721 phosphoprotein phosphatase activity
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0017124 SH3 domain binding
cellular component GO:0042995 cell projection
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005925 focal adhesion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0002102 podosome
Reactome
Pathway Id Pathway Name
R-HSA-1227986 Signaling by ERBB2
R-HSA-1227986 Signaling by ERBB2
R-HSA-1227990 Signaling by ERBB2 in Cancer
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-177929 Signaling by EGFR
R-HSA-182971 EGFR downregulation
R-HSA-186797 Signaling by PDGF
R-HSA-446652 Interleukin-1 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9008059 Interleukin-37 signaling
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0221292 BXGD004440 Basophilic leukemia Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409676 BXGD008393 Juvenile spondyloarthropathy Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0521158 BXGD009130 Recurrent tumor
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1336840 BXGD012866 Papillary renal cell carcinoma type 2 Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1708350 BXGD013598 Hereditary Leiomyomatosis and Renal Cell Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1842981 BXGD014547 NEUROTICISM Behavior and Behavior Mechanisms
C1853195 BXGD015313 Prostate Cancer, Hereditary, 7 Neoplasms; Male Urogenital Diseases
C1858361 BXGD015784 Pyogenic Arthritis, Pyoderma Gangrenosum and Acne Infections; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3495919 BXGD019013 Enthesitis-Related Arthritis Musculoskeletal Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3860213 BXGD019844 Autoinflammatory disorder
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001737 Norartocarpetin 286.24
BXGC0008181 Morusin 420.45
BXGC0035663 Cudraflavanone A 422.17
BXGC0039172 Oxyresveratrol 244.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein