Showing entry for Thyroid associated opthalmopathies


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007226
Disease NameThyroid associated opthalmopathies
Disease CUI IdC0339143
MeSH Codes C16   C11   C20   C19  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00767 BXGT003949 Acyl-CoA desaturase 6319 reviewed
O14773 BXGT004096 Tripeptidyl-peptidase 1 1200 reviewed Enzyme
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta 3551 reviewed Kinase
O15111 BXGT004126 Inhibitor of nuclear factor kappa-B kinase subunit alpha 1147 reviewed Kinase
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02741 BXGT005936 C-reactive protein 1401 reviewed
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05230 BXGT006344 Fibroblast growth factor 1 2246 reviewed Signaling
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08700 BXGT006816 Interleukin-3 3562 reviewed
P08887 BXGT006835 Interleukin-6 receptor subunit alpha 3570 reviewed Signaling
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09455 BXGT006890 Retinol-binding protein 1 5947 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P0DMV8 BXGT007509 Heat shock 70 kDa protein 1A 3304 reviewed
P0DMV9 BXGT007510 Heat shock 70 kDa protein 1B 3304 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12273 BXGT007787 Prolactin-inducible protein 5304 reviewed
P13489 BXGT007913 Ribonuclease inhibitor 6050 reviewed Transcription factor
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15559 BXGT008139 NAD(P)H dehydrogenase [quinone] 1 1728 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16473 BXGT008234 Thyrotropin receptor 7253 reviewed G-protein coupled receptor
P16581 BXGT008245 E-selectin 6401 reviewed
P16871 BXGT008269 Interleukin-7 receptor subunit alpha 3575 reviewed Receptor
P17643 BXGT008323 5,6-dihydroxyindole-2-carboxylic acid oxidase 7306 reviewed Enzyme
P17676 BXGT008327 CCAAT/enhancer-binding protein beta 1051 reviewed Transcription factor
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P21453 BXGT008654 Sphingosine 1-phosphate receptor 1 1901 reviewed G-protein coupled receptor
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P24593 BXGT008979 Insulin-like growth factor-binding protein 5 3488 reviewed Enzyme modulator
P25311 BXGT009036 Zinc-alpha-2-glycoprotein 563 reviewed
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27352 BXGT009174 Cobalamin binding intrinsic factor 2694 reviewed
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29460 BXGT009348 Interleukin-12 subunit beta 3593 reviewed Signaling
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30872 BXGT009474 Somatostatin receptor type 1 6751 reviewed G-protein coupled receptor
P30874 BXGT009475 Somatostatin receptor type 2 6752 reviewed G-protein coupled receptor
P31415 BXGT009537 Calsequestrin-1 844 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P33681 BXGT009739 T-lymphocyte activation antigen CD80 941 reviewed
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P40933 BXGT010209 Interleukin-15 3600 reviewed
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase 10135 reviewed Signaling
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P56945 BXGT011206 Breast cancer anti-estrogen resistance protein 1 9564 reviewed
P59666 BXGT011273 Neutrophil defensin 3 1668 reviewed
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61626 BXGT011382 Lysozyme C 4069 reviewed
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q7Z434 BXGT017252 Mitochondrial antiviral-signaling protein 57506 reviewed
Q8TDQ0 BXGT018810 Hepatitis A virus cellular receptor 2 84868 reviewed
Q8WXI4 BXGT019013 Acyl-coenzyme A thioesterase 11 26027 reviewed Enzyme
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NYK1 BXGT021258 Toll-like receptor 7 51284 reviewed
Q9Y275 BXGT022223 Tumor necrosis factor ligand superfamily member 13B 10673 reviewed
Q9Y2R2 BXGT022243 Tyrosine-protein phosphatase non-receptor type 22 26191 reviewed
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
O14958 BXGT025138 Calsequestrin-2 845 reviewed
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
Q05209 BXGT026141 Tyrosine-protein phosphatase non-receptor type 12 5782 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease