Showing entry for 1-phosphatidylinositol 3-phosphate 5-kinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026142
Protein Name1-phosphatidylinositol 3-phosphate 5-kinase
Uniport IdQ9Y2I7
GenePIKFYVE
Gene Id200576
DomainCpn60_TCP1; DEP; FYVE; PIP5K
Pfam PF00118   PF00610   PF01363   PF01504  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0032438 melanosome organization
Biological Process GO:0032288 myelin assembly
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0036289 peptidyl-serine autophosphorylation
Biological Process GO:0090385 phagosome-lysosome fusion
Biological Process GO:0090382 phagosome maturation
Biological Process GO:1904562 phosphatidylinositol 5-phosphate metabolic process
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0034504 protein localization to nucleus
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0019065 receptor-mediated endocytosis of virus by host cell
Biological Process GO:2000785 regulation of autophagosome assembly
Biological Process GO:1903426 regulation of reactive oxygen species biosynthetic process
Biological Process GO:0042147 retrograde transport, endosome to Golgi
molecular function GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity
molecular function GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
molecular function GO:0052810 1-phosphatidylinositol-5-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005911 cell-cell junction
cellular component GO:0005829 cytosol
cellular component GO:0031901 early endosome membrane
cellular component GO:0010008 endosome membrane
cellular component GO:0000139 Golgi membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0031902 late endosome membrane
cellular component GO:0045121 membrane raft
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0030670 phagocytic vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
R-HSA-556833 Metabolism of lipids
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0023240 BXGD001623 Legionellosis Infections; Respiratory Tract Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1562113 BXGD013372 Fleck corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1876214 BXGD016567 ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4021857 BXGD020820 Speckled corneal dystrophy
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein