adisease

Showing entry for Osteopenia

General Disease Information
BXGD Id	BXGD002154
Disease Name	Osteopenia
Disease CUI Id	C0029453
MeSH Codes	C18 C05
Disease Class Name	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000924
Human Phenotype Ontology Term	Abnormality of the skeletal system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00141	BXGT003882	Serine/threonine-protein kinase Sgk1	6446	reviewed	Kinase
O00214	BXGT003897	Galectin-8	3964	reviewed	Signaling
O00255	BXGT003903	Menin	4221	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00459	BXGT003924	Phosphatidylinositol 3-kinase regulatory subunit beta	5296	reviewed	Enzyme modulator
O00469	BXGT003926	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	5352	reviewed	Enzyme
O14684	BXGT004082	Prostaglandin E synthase	9536	reviewed
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O14744	BXGT004089	Protein arginine N-methyltransferase 5	10419	reviewed	Epigenetic regulator
O14745	BXGT004090	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	9368	reviewed
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O14842	BXGT004106	Free fatty acid receptor 1	2864	reviewed	G-protein coupled receptor
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O14924	BXGT004111	Regulator of G-protein signaling 12	6002	reviewed
O15120	BXGT004129	1-acyl-sn-glycerol-3-phosphate acyltransferase beta	10555	reviewed
O15164	BXGT004133	Transcription intermediary factor 1-alpha	8805	reviewed
O15305	BXGT004152	Phosphomannomutase 2	5373	reviewed	Enzyme
O15335	BXGT004153	Chondroadherin	1101	reviewed	Receptor
O15552	BXGT004180	Free fatty acid receptor 2	2867	reviewed	G-protein coupled receptor
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43854	BXGT004630	EGF-like repeat and discoidin I-like domain-containing protein 3	10085	reviewed	Enzyme
O43914	BXGT004635	TYRO protein tyrosine kinase-binding protein	7305	reviewed
O60568	BXGT004885	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	8985	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60678	BXGT004893	Protein arginine N-methyltransferase 3	10196	reviewed	Epigenetic regulator
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O60931	BXGT004911	Cystinosin	1497	reviewed
O75530	BXGT005135	Polycomb protein EED	8726	reviewed
O75581	BXGT005136	Low-density lipoprotein receptor-related protein 6	4040	reviewed
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
O94766	BXGT005330	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	26229	reviewed	Enzyme
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95150	BXGT005351	Tumor necrosis factor ligand superfamily member 15	9966	reviewed	Signaling
O95271	BXGT005369	Poly [ADP-ribose] polymerase tankyrase-1	8658	reviewed
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
O95644	BXGT005389	Nuclear factor of activated T-cells, cytoplasmic 1	4772	reviewed	Transcription factor
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01148	BXGT005739	Progonadoliberin-1	2796	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P02008	BXGT005832	Hemoglobin subunit zeta	3050	reviewed
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P02760	BXGT005948	Protein AMBP	259	reviewed
P02765	BXGT005952	Alpha-2-HS-glycoprotein	197	reviewed	Enzyme modulator
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P02794	BXGT005967	Ferritin heavy chain	2495	reviewed	Storage
P02818	BXGT005969	Osteocalcin	632	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04003	BXGT006124	C4b-binding protein alpha chain	722	reviewed
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04156	BXGT006156	Major prion protein	5621	reviewed
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05108	BXGT006317	Cholesterol side-chain cleavage enzyme, mitochondrial	1583	reviewed
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05186	BXGT006338	Alkaline phosphatase, tissue-nonspecific isozyme	249	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07237	BXGT006576	Protein disulfide-isomerase	5034	reviewed
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07602	BXGT006646	Prosaposin	5660	reviewed
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08670	BXGT006810	Vimentin	7431	reviewed
P08700	BXGT006816	Interleukin-3	3562	reviewed
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P0DMV8	BXGT007509	Heat shock 70 kDa protein 1A	3304	reviewed
P0DMV9	BXGT007510	Heat shock 70 kDa protein 1B	3304	reviewed
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14550	BXGT008019	Aldo-keto reductase family 1 member A1	10327	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15090	BXGT008079	Fatty acid-binding protein, adipocyte	2167	reviewed
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16070	BXGT008186	CD44 antigen	960	reviewed
P16333	BXGT008219	Cytoplasmic protein NCK1	4690	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P16471	BXGT008233	Prolactin receptor	5618	reviewed	Signaling
P17050	BXGT008277	Alpha-N-acetylgalactosaminidase	4668	reviewed
P17066	BXGT008279	Heat shock 70 kDa protein 6	3310	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17612	BXGT008322	cAMP-dependent protein kinase catalytic subunit alpha	5566	reviewed	Kinase
P17706	BXGT008330	Tyrosine-protein phosphatase non-receptor type 2	5771	reviewed
P17735	BXGT008335	Tyrosine aminotransferase	6898	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18075	BXGT008375	Bone morphogenetic protein 7	655	reviewed	Signaling
P18433	BXGT008403	Receptor-type tyrosine-protein phosphatase alpha	5786	reviewed	Enzyme
P18848	BXGT008432	Cyclic AMP-dependent transcription factor ATF-4	468	reviewed
P19174	BXGT008467	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	5335	reviewed	Enzyme
P19440	BXGT008481	Glutathione hydrolase 1 proenzyme	2678	reviewed	Enzyme
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21453	BXGT008654	Sphingosine 1-phosphate receptor 1	1901	reviewed	G-protein coupled receptor
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21675	BXGT008678	Transcription initiation factor TFIID subunit 1	6872	reviewed	Kinase
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22681	BXGT008795	E3 ubiquitin-protein ligase CBL	867	reviewed	Enzyme
P22736	BXGT008800	Nuclear receptor subfamily 4 group A member 1	3164	reviewed	Nuclear receptor
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P23945	BXGT008931	Follicle-stimulating hormone receptor	2492	reviewed	G-protein coupled receptor
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25325	BXGT009038	3-mercaptopyruvate sulfurtransferase	4357	reviewed	Enzyme
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	3290	reviewed
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29275	BXGT009328	Adenosine receptor A2b	136	reviewed	G-protein coupled receptor
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29375	BXGT009338	Lysine-specific demethylase 5A	5927	reviewed
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30536	BXGT009435	Translocator protein	706	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P30988	BXGT009491	Calcitonin receptor	799	reviewed	G-protein coupled receptor
P31639	BXGT009556	Sodium/glucose cotransporter 2	6524	reviewed	Transporter
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P32322	BXGT009624	Pyrroline-5-carboxylate reductase 1, mitochondrial	5831	reviewed
P32754	BXGT009664	4-hydroxyphenylpyruvate dioxygenase	3242	reviewed	Enzyme
P34972	BXGT009779	Cannabinoid receptor 2	1269	reviewed	G-protein coupled receptor
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38435	BXGT010040	Vitamin K-dependent gamma-carboxylase	2677	reviewed
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P40967	BXGT010212	Melanocyte protein PMEL	6490	reviewed	Signaling
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41231	BXGT010240	P2Y purinoceptor 2	5029	reviewed	G-protein coupled receptor
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42702	BXGT010335	Leukemia inhibitory factor receptor	3977	reviewed	Signaling
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43026	BXGT010351	Growth/differentiation factor 5	8200	reviewed	Signaling
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P43405	BXGT010386	Tyrosine-protein kinase SYK	6850	reviewed	Kinase
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P46937	BXGT010554	Transcriptional coactivator YAP1	10413	reviewed	Enzyme modulator
P47900	BXGT010595	P2Y purinoceptor 1	5028	reviewed	G-protein coupled receptor
P48048	BXGT010610	ATP-sensitive inward rectifier potassium channel 1	3758	reviewed	Ion channel
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49137	BXGT010680	MAP kinase-activated protein kinase 2	9261	reviewed	Kinase
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50281	BXGT010788	Matrix metalloproteinase-14	4323	reviewed	Enzyme
P51575	BXGT010861	P2X purinoceptor 1	5023	reviewed	Ion channel
P51677	BXGT010876	C-C chemokine receptor type 3	1232	reviewed	G-protein coupled receptor
P51812	BXGT010893	Ribosomal protein S6 kinase alpha-3	6197	reviewed	Kinase
P52564	BXGT010932	Dual specificity mitogen-activated protein kinase kinase 6	5608	reviewed	Kinase
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P54652	BXGT011064	Heat shock-related 70 kDa protein 2	3306	reviewed
P54886	BXGT011092	Delta-1-pyrroline-5-carboxylate synthase	5832	reviewed	Enzyme
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P56373	BXGT011164	P2X purinoceptor 3	5024	reviewed	Ion channel
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P58335	BXGT011233	Anthrax toxin receptor 2	118429	reviewed	Receptor
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61011	BXGT011346	Signal recognition particle 54 kDa protein	6729	reviewed	Nucleic acid binding
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P62508	BXGT011431	Estrogen-related receptor gamma	2104	reviewed	Nuclear receptor
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P80365	BXGT011895	Corticosteroid 11-beta-dehydrogenase isozyme 2	3291	reviewed	Enzyme
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
P81172	BXGT011935	Hepcidin	57817	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	4791	reviewed	Transcription factor
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q02779	BXGT012670	Mitogen-activated protein kinase kinase kinase 10	4294	reviewed	Kinase
Q03431	BXGT012714	Parathyroid hormone/parathyroid hormone-related peptide receptor	5745	reviewed	G-protein coupled receptor
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q04912	BXGT012790	Macrophage-stimulating protein receptor	4486	reviewed	Kinase
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06520	BXGT012880	Bile salt sulfotransferase	6822	reviewed
Q06830	BXGT012894	Peroxiredoxin-1	5052	reviewed	Enzyme
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q10469	BXGT013200	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	4247	reviewed	Enzyme
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q13118	BXGT013312	Krueppel-like factor 10	7071	reviewed	Nucleic acid binding
Q13126	BXGT013313	S-methyl-5'-thioadenosine phosphorylase	4507	reviewed	Enzyme
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13237	BXGT013331	cGMP-dependent protein kinase 2	5593	reviewed	Kinase
Q13285	BXGT013335	Steroidogenic factor 1	2516	reviewed	Nuclear receptor
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13427	BXGT013354	Peptidyl-prolyl cis-trans isomerase G	9360	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13563	BXGT013377	Polycystin-2	5311	reviewed	Ion channel
Q13621	BXGT013383	Solute carrier family 12 member 1	6557	reviewed	Transporter
Q13627	BXGT013385	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	1859	reviewed	Kinase
Q14108	BXGT013440	Lysosome membrane protein 2	950	reviewed	Receptor
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14145	BXGT013448	Kelch-like ECH-associated protein 1	9817	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14469	BXGT013473	Transcription factor HES-1	3280	reviewed	Transcription factor
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15020	BXGT013522	Squamous cell carcinoma antigen recognized by T-cells 3	9733	reviewed	Nucleic acid binding
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15493	BXGT013575	Regucalcin	9104	reviewed	Enzyme
Q15788	BXGT013598	Nuclear receptor coactivator 1	8648	reviewed	Kinase
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16654	BXGT013650	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	5166	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16828	BXGT013676	Dual specificity protein phosphatase 6	1848	reviewed
Q2M385	BXGT014131	Macrophage-expressed gene 1 protein	219972	reviewed
Q2MKA7	BXGT014140	R-spondin-1	284654	reviewed
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q32P28	BXGT014324	Prolyl 3-hydroxylase 1	64175	reviewed	Extracellular structure
Q6VVX0	BXGT016585	Vitamin D 25-hydroxylase	120227	reviewed
Q7KZF4	BXGT016989	Staphylococcal nuclease domain-containing protein 1	27044	reviewed	Transcription factor
Q86WV6	BXGT017626	Stimulator of interferon genes protein	340061	reviewed
Q8N6T7	BXGT018525	NAD-dependent protein deacetylase sirtuin-6	51548	reviewed	Epigenetic regulator
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8TCT1	BXGT018800	Phosphoethanolamine/phosphocholine phosphatase	162466	reviewed	Enzyme
Q8TDU6	BXGT018814	G-protein coupled bile acid receptor 1	151306	reviewed	G-protein coupled receptor
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92830	BXGT019379	Histone acetyltransferase KAT2A	2648	reviewed
Q92854	BXGT019385	Semaphorin-4D	10507	reviewed	Signaling
Q969Q1	BXGT019610	E3 ubiquitin-protein ligase TRIM63	84676	reviewed
Q96D31	BXGT019635	Calcium release-activated calcium channel protein 1	84876	reviewed	Ion channel
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96EQ8	BXGT019652	E3 ubiquitin-protein ligase RNF125	54941	reviewed
Q96F46	BXGT019656	Interleukin-17 receptor A	23765	reviewed
Q96IV0	BXGT019677	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	55768	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PN6	BXGT019709	Adenylate cyclase type 10	55811	reviewed
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q96SW2	BXGT019743	Protein cereblon	51185	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99704	BXGT019950	Docking protein 1	1796	reviewed
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q99873	BXGT019972	Protein arginine N-methyltransferase 1	3276	reviewed	Epigenetic regulator
Q9BQB6	BXGT020108	Vitamin K epoxide reductase complex subunit 1	79001	reviewed	Enzyme
Q9BUF5	BXGT020135	Tubulin beta-6 chain	84617	reviewed	Cellular structure
Q9BYF1	BXGT020186	Angiotensin-converting enzyme 2	59272	reviewed	Enzyme
Q9BYV1	BXGT020191	Alanine--glyoxylate aminotransferase 2, mitochondrial	64902	reviewed
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZT9	BXGT020425	Egl nine homolog 1	54583	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H1D0	BXGT020445	Transient receptor potential cation channel subfamily V member 6	55503	reviewed	Ion channel
Q9H244	BXGT020448	P2Y purinoceptor 12	64805	reviewed	G-protein coupled receptor
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9H3H5	BXGT020461	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	1798	reviewed	Enzyme
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9H6W3	BXGT020485	Ribosomal oxygenase 1	79697	reviewed
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9HC97	BXGT020527	G-protein coupled receptor 35	2859	reviewed	G-protein coupled receptor
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9HD26	BXGT020540	Golgi-associated PDZ and coiled-coil motif-containing protein	57120	reviewed
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NP99	BXGT021148	Triggering receptor expressed on myeloid cells 1	54210	reviewed
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NSD9	BXGT021206	Phenylalanine--tRNA ligase beta subunit	10056	reviewed	Enzyme
Q9NSE4	BXGT021207	Isoleucine--tRNA ligase, mitochondrial	55699	reviewed	Enzyme
Q9NTG7	BXGT021211	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	23410	reviewed	Epigenetic regulator
Q9NWM8	BXGT021233	Peptidyl-prolyl cis-trans isomerase FKBP14	55033	reviewed
Q9NXG6	BXGT021246	Transmembrane prolyl 4-hydroxylase	54681	reviewed
Q9NY33	BXGT021247	Dipeptidyl peptidase 3	10072	reviewed	Enzyme
Q9NYA1	BXGT021254	Sphingosine kinase 1	8877	reviewed	Kinase
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UBL9	BXGT021656	P2X purinoceptor 2	22953	reviewed	Ion channel
Q9UBM7	BXGT021657	7-dehydrocholesterol reductase	1717	reviewed	Enzyme
Q9UBV7	BXGT021665	Beta-1,4-galactosyltransferase 7	11285	reviewed
Q9UHF0	BXGT021699	Tachykinin-3	6866	reviewed
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q9UKV8	BXGT021752	Protein argonaute-2	27161	reviewed
Q9ULW0	BXGT021766	Targeting protein for Xklp2	22974	reviewed	Cellular structure
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9UNA0	BXGT021784	A disintegrin and metalloproteinase with thrombospondin motifs 5	11096	reviewed	Enzyme
Q9UPZ9	BXGT021804	Serine/threonine-protein kinase ICK	22858	reviewed	Kinase
Q9UQD0	BXGT021811	Sodium channel protein type 8 subunit alpha	6334	reviewed	Ion channel
Q9UQF0	BXGT021812	Syncytin-1	30816	reviewed
Q9Y271	BXGT022222	Cysteinyl leukotriene receptor 1	10800	reviewed	G-protein coupled receptor
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y289	BXGT022226	Sodium-dependent multivitamin transporter	8884	reviewed	Transporter
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y5W5	BXGT022303	Wnt inhibitory factor 1	11197	reviewed	Calcium-binding protein
Q9Y5X0	BXGT022305	Sorting nexin-10	29887	reviewed
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q9Y6U3	BXGT022341	Adseverin	85477	reviewed	Cellular structure
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
Q9UNS1	BXGT022882	Protein timeless homolog	8914	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
O14793	BXGT023280	Growth/differentiation factor 8	2660	reviewed	Signaling
P19875	BXGT023294	C-X-C motif chemokine 2	2920	reviewed	Signaling
P31994	BXGT023298	Low affinity immunoglobulin gamma Fc region receptor II-b	2213	reviewed	Cell adhesion
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P56703	BXGT023722	Proto-oncogene Wnt-3	7473	reviewed	Signaling
Q9Y294	BXGT023981	Histone chaperone ASF1A	25842	reviewed	Nucleic acid binding
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
P08123	BXGT024477	Collagen alpha-2(I) chain	1278	reviewed
Q96L73	BXGT024676	Histone-lysine N-methyltransferase, H3 lysine-36 specific	64324	reviewed	Epigenetic regulator
Q96A54	BXGT024681	Adiponectin receptor protein 1	51094	reviewed	Receptor
Q9UNE7	BXGT025000	E3 ubiquitin-protein ligase CHIP	10273	reviewed
Q9Y4W6	BXGT025025	AFG3-like protein 2	10939	reviewed	Enzyme
P20809	BXGT025043	Interleukin-11	3589	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
Q9BYC5	BXGT025656	Alpha-(1,6)-fucosyltransferase	2530	reviewed
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme
Q9UKU9	BXGT025985	Angiopoietin-related protein 2	23452	reviewed	Signaling
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
Q9Y2I7	BXGT026142	1-phosphatidylinositol 3-phosphate 5-kinase	200576	reviewed	Kinase
P07320	BXGT026150	Gamma-crystallin D	1421	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}