Showing entry for Phylloquinone omega-hydroxylase CYP4F2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026166
Protein NamePhylloquinone omega-hydroxylase CYP4F2
Uniport IdP78329
GeneCYP4F2
Gene Id8529
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0007596 blood coagulation
Biological Process GO:0017144 drug metabolic process
Biological Process GO:0019373 epoxygenase P450 pathway
Biological Process GO:0006690 icosanoid metabolic process
Biological Process GO:0036101 leukotriene B4 catabolic process
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:0001676 long-chain fatty acid metabolic process
Biological Process GO:0042361 menaquinone catabolic process
Biological Process GO:0032304 negative regulation of icosanoid secretion
Biological Process GO:0097267 omega-hydroxylase P450 pathway
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0042376 phylloquinone catabolic process
Biological Process GO:0032305 positive regulation of icosanoid secretion
Biological Process GO:0003095 pressure natriuresis
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0003091 renal water homeostasis
Biological Process GO:0055078 sodium ion homeostasis
Biological Process GO:0000038 very long-chain fatty acid metabolic process
Biological Process GO:0042360 vitamin E metabolic process
Biological Process GO:0042377 vitamin K catabolic process
molecular function GO:0018685 alkane 1-monooxygenase activity
molecular function GO:0052871 alpha-tocopherol omega-hydroxylase activity
molecular function GO:0008392 arachidonic acid epoxygenase activity
molecular function GO:0008391 arachidonic acid monooxygenase activity
molecular function GO:0052869 arachidonic acid omega-hydroxylase activity
molecular function GO:0070330 aromatase activity
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0050051 leukotriene-B4 20-monooxygenase activity
molecular function GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
molecular function GO:0052872 tocotrienol omega-hydroxylase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211935 Fatty acids
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211958 Miscellaneous substrates
R-HSA-211979 Eicosanoids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042879 BXGD003010 Vitamin K Assay
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0340288 BXGD007316 Stable angina Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1142098 BXGD011728 Vitamin E Assay
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1504532 BXGD013149 Post transplant diabetes mellitus
C1709246 BXGD013622 Non-Neoplastic Disorder Pathological Conditions, Signs and Symptoms
C1709735 BXGD013631 Prosthetic Valve Thrombosis Cardiovascular Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2608079 BXGD017154 WARFARIN SENSITIVITY (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4282128 BXGD022420 PATENT DUCTUS ARTERIOSUS 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0041820 Schisantherin E 538.22
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein