Showing entry for Adrenoleukodystrophy


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD003934
Disease NameAdrenoleukodystrophy
Disease CUI IdC0162309
MeSH Codes C16   C18   C10   C19  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14594 BXGT004073 Neurocan core protein 1463 reviewed Extracellular structure
O14832 BXGT004104 Phytanoyl-CoA dioxygenase, peroxisomal 5264 reviewed
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75581 BXGT005136 Low-density lipoprotein receptor-related protein 6 4040 reviewed
O95342 BXGT005373 Bile salt export pump 8647 reviewed Transporter
P00325 BXGT005498 Alcohol dehydrogenase 1B 125 reviewed Enzyme
P00326 BXGT005499 Alcohol dehydrogenase 1C 126 reviewed Enzyme
P01031 BXGT005720 Complement C5 727 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02730 BXGT005935 Band 3 anion transport protein 6521 reviewed Transporter
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06126 BXGT006412 T-cell surface glycoprotein CD1a 909 reviewed
P06276 BXGT006430 Cholinesterase 590 reviewed
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07355 BXGT006609 Annexin A2 302 reviewed
P07477 BXGT006629 Trypsin-1 5644 reviewed Enzyme
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P08034 BXGT006716 Gap junction beta-1 protein 2705 reviewed Cell-cell junction
P08246 BXGT006756 Neutrophil elastase 1991 reviewed Enzyme
P08263 BXGT006759 Glutathione S-transferase A1 2938 reviewed
P08686 BXGT006813 Steroid 21-hydroxylase 1589 reviewed
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11766 BXGT007745 Alcohol dehydrogenase class-3 128 reviewed Enzyme
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 10327 reviewed Enzyme
P15104 BXGT008081 Glutamine synthetase 2752 reviewed Enzyme
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 231 reviewed Enzyme
P15813 BXGT008158 Antigen-presenting glycoprotein CD1d 912 reviewed
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P16050 BXGT008184 Arachidonate 15-lipoxygenase 246 reviewed Enzyme
P16070 BXGT008186 CD44 antigen 960 reviewed
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P17861 BXGT008348 X-box-binding protein 1 7494 reviewed
P18848 BXGT008432 Cyclic AMP-dependent transcription factor ATF-4 468 reviewed
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21730 BXGT008687 C5a anaphylatoxin chemotactic receptor 1 728 reviewed G-protein coupled receptor
P22087 BXGT008729 rRNA 2'-O-methyltransferase fibrillarin 2091 reviewed Enzyme
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 54658 reviewed
P23141 BXGT008830 Liver carboxylesterase 1 1066 reviewed Enzyme
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P24855 BXGT008998 Deoxyribonuclease-1 1773 reviewed
P25440 BXGT009044 Bromodomain-containing protein 2 6046 reviewed Epigenetic regulator
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A 5141 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28845 BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 3290 reviewed
P29016 BXGT009304 T-cell surface glycoprotein CD1b 910 reviewed
P29017 BXGT009305 T-cell surface glycoprotein CD1c 911 reviewed
P29460 BXGT009348 Interleukin-12 subunit beta 3593 reviewed Signaling
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P30405 BXGT009423 Peptidyl-prolyl cis-trans isomerase F, mitochondrial 10105 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase 10135 reviewed Signaling
P43652 BXGT010405 Afamin 173 reviewed Transporter
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P48029 BXGT010606 Sodium- and chloride-dependent creatine transporter 1 6535 reviewed Transporter
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49281 BXGT010689 Natural resistance-associated macrophage protein 2 4891 reviewed Transporter
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P51572 BXGT010859 B-cell receptor-associated protein 31 10134 reviewed Transporter
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60903 BXGT011339 Protein S100-A10 6281 reviewed Calcium-binding protein
P63279 BXGT011514 SUMO-conjugating enzyme UBC9 7329 reviewed
P81172 BXGT011935 Hepcidin 57817 reviewed
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q00610 BXGT012539 Clathrin heavy chain 1 1213 reviewed Transporter
Q01453 BXGT012588 Peripheral myelin protein 22 5376 reviewed Cellular structure
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta 5467 reviewed Nuclear receptor
Q07157 BXGT012920 Tight junction protein ZO-1 7082 reviewed Cell-cell junction
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q08170 BXGT012962 Serine/arginine-rich splicing factor 4 6429 reviewed Nucleic acid binding
Q09013 BXGT013023 Myotonin-protein kinase 1760 reviewed Kinase
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13231 BXGT013329 Chitotriosidase-1 1118 reviewed
Q13285 BXGT013335 Steroidogenic factor 1 2516 reviewed Nuclear receptor
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14653 BXGT013494 Interferon regulatory factor 3 3661 reviewed Transcription factor
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15382 BXGT013563 GTP-binding protein Rheb 6009 reviewed Enzyme modulator
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16549 BXGT013637 Proprotein convertase subtilisin/kexin type 7 9159 reviewed
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16836 BXGT013679 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 3033 reviewed
Q16874 BXGT013685 Cytochrome P450 21-hydroxylase 1589 unreviewed
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 51548 reviewed Epigenetic regulator
Q8NBP7 BXGT018541 Proprotein convertase subtilisin/kexin type 9 255738 reviewed Enzyme
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96PD4 BXGT019705 Interleukin-17F 112744 reviewed
Q96RI1 BXGT019727 Bile acid receptor 9971 reviewed Nuclear receptor
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NPH5 BXGT021159 NADPH oxidase 4 50507 reviewed Enzyme
Q9NRA0 BXGT021183 Sphingosine kinase 2 56848 reviewed Kinase
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9P0Z9 BXGT021294 Peroxisomal sarcosine oxidase 51268 reviewed Enzyme
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9Y243 BXGT022214 RAC-gamma serine/threonine-protein kinase 10000 reviewed Kinase
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y5X0 BXGT022305 Sorting nexin-10 29887 reviewed
Q9Y5Y6 BXGT022308 Suppressor of tumorigenicity 14 protein 6768 reviewed Enzyme
O60936 BXGT022857 Nucleolar protein 3 8996 reviewed
O14793 BXGT023280 Growth/differentiation factor 8 2660 reviewed Signaling
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
P78329 BXGT026166 Phylloquinone omega-hydroxylase CYP4F2 8529 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease