adisease

Showing entry for Varicosity

General Disease Information
BXGD Id	BXGD002977
Disease Name	Varicosity
Disease CUI Id	C0042345
MeSH Codes	C14
Disease Class Name	Cardiovascular Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001626
Human Phenotype Ontology Term	Abnormality of the cardiovascular system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O43612	BXGT004605	Orexin	3060	reviewed
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	57016	reviewed	Enzyme
O75116	BXGT005100	Rho-associated protein kinase 2	9475	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P05106	BXGT006315	Integrin beta-3	3690	reviewed	Receptor
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05160	BXGT006330	Coagulation factor XIII B chain	2165	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P05937	BXGT006396	Calbindin	793	reviewed	Calcium-binding protein
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P08138	BXGT006729	Tumor necrosis factor receptor superfamily member 16	4804	reviewed	Receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12955	BXGT007865	Xaa-Pro dipeptidase	5184	reviewed	Enzyme
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15309	BXGT008105	Prostatic acid phosphatase	55	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15924	BXGT008171	Desmoplakin	1832	reviewed	Cellular structure
P16581	BXGT008245	E-selectin	6401	reviewed
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P20936	BXGT008619	Ras GTPase-activating protein 1	5921	reviewed	Enzyme modulator
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P35916	BXGT009881	Vascular endothelial growth factor receptor 3	2324	reviewed	Kinase
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P40337	BXGT010174	von Hippel-Lindau disease tumor suppressor	7428	reviewed	Enzyme
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42858	BXGT010341	Huntingtin	3064	reviewed
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P49767	BXGT010739	Vascular endothelial growth factor C	7424	reviewed	Signaling
P54760	BXGT011075	Ephrin type-B receptor 4	2050	reviewed	Kinase
P60903	BXGT011339	Protein S100-A10	6281	reviewed	Calcium-binding protein
P61586	BXGT011375	Transforming protein RhoA	387	reviewed	Enzyme modulator
P78504	BXGT011844	Protein jagged-1	182	reviewed
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q02928	BXGT012680	Cytochrome P450 4A11	1579	reviewed	Enzyme
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q12840	BXGT013269	Kinesin heavy chain isoform 5A	3798	reviewed	Cellular structure
Q13255	BXGT013332	Metabotropic glutamate receptor 1	2911	reviewed	G-protein coupled receptor
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q8WUI4	BXGT018992	Histone deacetylase 7	51564	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q9BV57	BXGT020140	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	55256	reviewed	Enzyme
Q9BY11	BXGT020178	Protein kinase C and casein kinase substrate in neurons protein 1	29993	reviewed	Cellular structure
Q9C098	BXGT020208	Serine/threonine-protein kinase DCLK3	85443	reviewed	Kinase
Q9H6Z9	BXGT020488	Egl nine homolog 3	112399	reviewed
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9UGI6	BXGT021681	Small conductance calcium-activated potassium channel protein 3	3782	reviewed	Ion channel
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9Y5S1	BXGT022300	Transient receptor potential cation channel subfamily V member 2	51393	reviewed	Ion channel
Q9Y5Z0	BXGT022310	Beta-secretase 2	25825	reviewed	Enzyme
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P09622	BXGT023116	Dihydrolipoyl dehydrogenase, mitochondrial	1738	reviewed	Enzyme
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
Q63ZY3	BXGT023544	KN motif and ankyrin repeat domain-containing protein 2	25959	reviewed
Q99958	BXGT023732	Forkhead box protein C2	2303	reviewed	Transcription factor
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
P78329	BXGT026166	Phylloquinone omega-hydroxylase CYP4F2	8529	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}