Showing entry for Girinimbine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001476
Compound NameGirinimbine
Structure
FormulaC18H17NO
InchiKeyGAEQWKVGMHUUKO-UHFFFAOYSA-N
SMILESCC1=C2OC(C)(C)C=CC2=C2NC3=CC=CC=C3C2=C1
InchiInChI=1S/C18H17NO/c1-11-10-14-12-6-4-5-7-15(12)19-16(14)13-8-9-18(2,3)20-17(11)13/h4-10,19H,1-3H3
IUPAC3,3,5-trimethyl-3H,11H-pyrano[3,2-a]carbazole
Molecular Weight263.33
Pubchem Id96943
Chembl IdCHEMBL1477760
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 68168
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009858 DNA damage-inducible transcript 3 protein reviewed Ddit3 - 1030 - -
reviewed BXGT008348 X-box-binding protein 1 reviewed XBP1 - 1100 - -
CHEMBL CHEMBL1477760
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 18356 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 10000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 29092 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 89125 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 3162 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 18348 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20587 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 56234 nM
P35639 BXGT009858 DNA damage-inducible transcript 3 protein reviewed - Ddit3 IC50 '=' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 28183 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 39810 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 89125 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 22387 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 22387 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 50118 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 25929 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 3162 nM
P17861 BXGT008348 X-box-binding protein 1 reviewed - XBP1 IC50 '=' 10000 nM
Q77YF9 BXGT016886 Protein Vpr unreviewed - vpr Potency - 25118 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 10691 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 28183 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00818 Herbs and Spices Herbs and Spices
BXGF02478 Murraya siamensis Murraya siamensis Medicinal Plant
BXGF02629 Clausena vestita Clausena vestita Others
BXGF03366 Clausena harmandiana Clausena harmandiana Medicinal Plant
BXGF03694 Otholobium pubescens Otholobium pubescens Others
BXGF03909 Iris sanguinea Iris sanguinea Others
BXGF04412 Rhododendron edgeworthii Rhododendron edgeworthii Others
BXGF04443 Populus candicans Populus candicans Others
BXGF04655 Gutenbergia marginata Gutenbergia marginata Others
BXGF04670 Griselinia scandens Griselinia scandens Others
BXGF04684 Podocalyx loranthoides Podocalyx loranthoides Others
BXGF04703 Trixis grisebachii Trixis grisebachii Others
BXGF04721 Helicia erratica Helicia erratica Human Edible Plant
BXGF04774 Croton hutchinsonianus Croton hutchinsonianus Others
BXGF04790 Cicer cuneatum Cicer cuneatum Others
BXGF04803 Bulbine asphodeloides Bulbine asphodeloides Medicinal Plant
BXGF04805 Ipomoea carnea Ipomoea carnea Medicinal Plant
BXGF04810 Yucca elata Yucca elata Medicinal Plant
BXGF04820 Panax ginseng Panax ginseng 0
BXGF04828 Hyptis urticoides Hyptis urticoides Others
BXGF04833 Monachosorum maximowiczii Monachosorum maximowiczii Others
BXGF04888 Sarcophyton infundibuliforme Sarcophyton infundibuliforme Others
BXGF04895 Delphinium speciosum Delphinium speciosum Others
BXGF04899 Nardia scalaris Nardia scalaris Others
BXGF05075 Murraya koenigii Murraya koenigii Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease