Showing entry for Phlororrhizin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0003788
Compound NamePhlororrhizin
Structure
FormulaC21H24O10
InchiKeyIOUVKUPGCMBWBT-QNDFHXLGSA-N
SMILESOC[C@H]1O[C@@H](OC2=CC(O)=CC(O)=C2C(=O)CCC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InchiInChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
IUPAC1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one
Molecular Weight436.41
Pubchem Id6072
Chembl IdCHEMBL245067
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 20875
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - - - 35.6
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - - - 330
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 19 - - -
reviewed BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 - 41720 - -
reviewed BXGT004631 Sodium/nucleoside cotransporter 2 reviewed Transporter SLC28A2 - >1000000 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 110000 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 64300 - - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 200 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 100 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - - - 35
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - - - 160
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 752 - -
reviewed BXGT020507 Solute carrier family 28 member 3 reviewed Transporter SLC28A3 16000 - - -
reviewed BXGT003911 Sodium/nucleoside cotransporter 1 reviewed Transporter SLC28A1 - 250000 - -
reviewed BXGT004631 Sodium/nucleoside cotransporter 2 reviewed Transporter SLC28A2 - 100000 - -
reviewed BXGT019964 Equilibrative nucleoside transporter 1 reviewed Transporter SLC29A1 >1000000 - - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - - - 123
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - - - 153
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 200000 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 100000 - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 246 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 28 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 36 - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 330 - -
reviewed BXGT021253 Solute carrier family 5 member 4 reviewed Transporter SLC5A4 - 16 - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 190 - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 180 - - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 210 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - - - 108
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - - - 197.4
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 16 - -
reviewed BXGT011016 Sodium/glucose cotransporter 1 reviewed Slc5a1 - 350 - -
reviewed BXGT011017 Sodium/glucose cotransporter 2 reviewed Slc5a2 - 96 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 38 - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 536 - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 185 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 16.4 - -
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - - - 120
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - - - 77
reviewed BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 - 61 - -
reviewed BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 - 59 - -
CHEMBL CHEMBL245067
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 27 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 60 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' -6 %
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 38 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 34 %
Q9HAS3 BXGT020507 Solute carrier family 28 member 3 reviewed Transporter SLC28A3 Ki '=' 16000 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 EC50 '=' 153 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 106 %
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 Inhibition '>' 40 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Activity - - -
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 reviewed Enzyme AKR1B10 Inhibition - - -
O43868 BXGT004631 Sodium/nucleoside cotransporter 2 reviewed Transporter SLC28A2 IC50 '=' 100000 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 Inhibition '=' 30 %
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 Inhibition '=' 80 %
O00337 BXGT003911 Sodium/nucleoside cotransporter 1 reviewed Transporter SLC28A1 IC50 '=' 250000 nM
P53790 BXGT011016 Sodium/glucose cotransporter 1 reviewed - Slc5a1 IC50 '=' 350 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 536 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 210 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 190 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 35481 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 EC50 '=' 77 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 EC50 '=' 35 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 EC50 '=' 35 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 246 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 100 nM
O43868 BXGT004631 Sodium/nucleoside cotransporter 2 reviewed Transporter SLC28A2 Inhibition '=' 14 %
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 752 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 Inhibition '=' 50 %
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 EC50 '=' 330 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 Ki '=' 18 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 EC50 '=' 108 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 Inhibition - - -
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 316 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 EC50 '=' 197 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 200 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 200000 nM
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 IC50 '=' 41720 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 36 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 330 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 185 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 100000 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 Ki '=' 180 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 16 nM
Q99808 BXGT019964 Equilibrative nucleoside transporter 1 reviewed Transporter SLC29A1 Ki '>' 1000000 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 58 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 50 %
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 EC50 '=' 79 nM
O43868 BXGT004631 Sodium/nucleoside cotransporter 2 reviewed Transporter SLC28A2 IC50 '>' 1000000 nM
Q9NY91 BXGT021253 Solute carrier family 5 member 4 reviewed Transporter SLC5A4 IC50 '=' 16 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 5 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ratio IC50 - - -
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 16 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 45 %
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 EC50 '=' 120 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 47 %
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 Inhibition - - -
P53792 BXGT011017 Sodium/glucose cotransporter 2 reviewed - Slc5a2 IC50 '=' 96 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 EC50 '=' 160 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 31 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 52 %
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 EC50 '=' 123 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP IC50 '>' 300000 nM
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 IC50 '=' 499 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 IC50 '=' 67 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP IC50 '=' 29 ug.mL-1
O43868 BXGT004631 Sodium/nucleoside cotransporter 2 reviewed Transporter SLC28A2 Inhibition '<' 50 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 9 %
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 EC50 '=' 240 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00102 Mexican oregano Lippia graveolens Herbs and Spices
BXGF00105 Apple Malus pumila Fruits
BXGF00144 Apricot Prunus armeniaca Fruits
BXGF00147 European plum Prunus domestica Fruits
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00152 Pear Pyrus communis Fruits
BXGF00162 Red raspberry Rubus idaeus Fruits
BXGF00303 Chia Salvia hispanica Herbs and Spices
BXGF00317 Malus (Crab apple) Malus Fruits
BXGF00808 Pomes Fruits
BXGF00989 Asteriscus aquaticus Asteriscus aquaticus Others
BXGF00998 Syncarpia hillii Syncarpia hillii Others
BXGF01018 Cinnamomum subavenium Cinnamomum subavenium Medicinal Plant
BXGF01102 Pseudowintera colorata Pseudowintera colorata Others
BXGF01180 Phebalium dentatum Phebalium dentatum Others
BXGF01217 Ecballium elaterium Ecballium elaterium Medicinal Plant
BXGF01242 Capparis ovata Capparis ovata Medicinal Plant
BXGF01244 Croton montevidensis Croton montevidensis Others
BXGF01255 Lemaireocereus griseus Lemaireocereus griseus Human Edible Plant
BXGF01327 Datisca glomerata Datisca glomerata Others
BXGF01378 Quercus imbricaria Quercus imbricaria Medicinal Plant
BXGF01409 Dioscorea olfersiana Dioscorea olfersiana Human Edible Plant
BXGF01444 Cassine papillosa Cassine papillosa Human Edible Plant
BXGF01455 Diospyros eriantha Diospyros eriantha Others
BXGF01491 Alkanna cappadocica Alkanna cappadocica Medicinal Plant
BXGF01524 Artemisia dentata Artemisia dentata Others
BXGF01633 Scorzonera pseudodivaricata Scorzonera pseudodivaricata Others
BXGF01649 Rapanea lancifolia Rapanea lancifolia Others
BXGF01670 Ononis vaginalis Ononis vaginalis Others
BXGF01721 Humulus lupulus Humulus lupulus Medicinal Plant
BXGF02663 Atalantia racemosa Atalantia racemosa Medicinal Plant
BXGF02846 Kalmia latifolia Kalmia latifolia Medicinal Plant
BXGF03051 Phyllanthus oligospermus Phyllanthus oligospermus Others
BXGF03342 Buddleja cordata Buddleja cordata Others
BXGF03747 Millettia erythrocalyx Millettia erythrocalyx Medicinal Plant
BXGF03814 Juniperus rigida var. conferta Juniperus rigida var. conferta Medicinal Plant
BXGF03978 Hoffmannia strigillosa Hoffmannia strigillosa Others
BXGF04153 Solanum andigena Solanum andigena Others
BXGF05015 Balanophora involucrata Balanophora involucrata Medicinal Plant
BXGF05078 Alstonia undulifolia Alstonia undulifolia Others
BXGF05125 Solanum aethiopicum Solanum aethiopicum Medicinal Plant
BXGF05143 Scrophularia koelzii Scrophularia koelzii Medicinal Plant
BXGF05225 Betula platyphylla Betula platyphylla Medicinal Plant
BXGF05283 Polygonum flaccidum Polygonum flaccidum Medicinal Plant
BXGF05367 Toxicodendron vernicifluum Toxicodendron vernicifluum Medicinal Plant
BXGF05378 Hubertia tomentosa Hubertia tomentosa Others
BXGF05453 Ligustrum obtusifolium Ligustrum obtusifolium Medicinal Plant
BXGF05520 Euphorbia humifusa Euphorbia humifusa Medicinal Plant
BXGF05541 Helichrysum auriceps Helichrysum auriceps Others
BXGF05560 Crambe tatarica Crambe tatarica Medicinal Plant
BXGF05871 Fagus fusca Fagus fusca Others
BXGF05889 Spiracantha cornifolia Spiracantha cornifolia Others
BXGF05952 Tylophora tanakae Tylophora tanakae Others
BXGF06031 Myristica cagayanensis Myristica cagayanensis Others
BXGF06116 Pteris semipinnata Pteris semipinnata Others
BXGF06193 Fritillaria ningguoensis Fritillaria ningguoensis Medicinal Plant
BXGF06236 Charpentiera obovata Charpentiera obovata Others
BXGF06270 Lotus ucrainicus Lotus ucrainicus Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease