Showing entry for Sodium/glucose cotransporter 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007963
Protein NameSodium/glucose cotransporter 1
Uniport IdP13866
GeneSLC5A1
Gene Id6523
DomainSSF
Pfam PF00474  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000017 alpha-glucoside transport
Biological Process GO:0015756 fucose transmembrane transport
Biological Process GO:0015757 galactose transmembrane transport
Biological Process GO:0098708 glucose import across plasma membrane
Biological Process GO:1904659 glucose transmembrane transport
Biological Process GO:0106001 intestinal hexose absorption
Biological Process GO:0015798 myo-inositol transport
Biological Process GO:0015750 pentose transmembrane transport
Biological Process GO:0010035 response to inorganic substance
Biological Process GO:0098719 sodium ion import across plasma membrane
Biological Process GO:0006814 sodium ion transport
Biological Process GO:0035377 transepithelial water transport
Biological Process GO:0150104 transport across blood-brain barrier
molecular function GO:0015151 alpha-glucoside transmembrane transporter activity
molecular function GO:0055056 D-glucose transmembrane transporter activity
molecular function GO:0015150 fucose transmembrane transporter activity
molecular function GO:0005354 galactose transmembrane transporter activity
molecular function GO:0005412 glucose:sodium symporter activity
molecular function GO:0005355 glucose transmembrane transporter activity
molecular function GO:0005367 myo-inositol:sodium symporter activity
molecular function GO:0015146 pentose transmembrane transporter activity
molecular function GO:0005372 water transmembrane transporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0005911 cell-cell junction
cellular component GO:0005769 early endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043229 intracellular organelle
cellular component GO:0097708 intracellular vesicle
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-189200 Cellular hexose transport
R-HSA-382551 Transport of small molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-5619102 SLC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5656364 Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
R-HSA-8963676 Intestinal absorption
R-HSA-8963743 Digestion and absorption
R-HSA-8981373 Intestinal hexose absorption
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0004623 BXGD000282 Bacterial Infections Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008354 BXGD000533 Cholera Infections
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0014836 BXGD000954 Escherichia coli Infections Infections
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017741 BXGD001149 Glucose tolerance test
C0017979 BXGD001159 Glycosuria Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0021828 BXGD001515 Intestinal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023283 BXGD001629 Leishmaniasis, Cutaneous Infections; Skin and Connective Tissue Diseases
C0023860 BXGD001708 Listeriosis Infections
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027709 BXGD002026 Nephrocalcinosis Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036983 BXGD002652 Septic Shock Pathological Conditions, Signs and Symptoms; Infections
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0156149 BXGD003839 Gastrointestinal tract vascular insufficiency Digestive System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0232694 BXGD004557 Hyperactive bowel sounds
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0267556 BXGD005759 Osmotic diarrhea Digestive System Diseases
C0267557 BXGD005760 Secretory diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0268186 BXGD005848 Congenital glucose-galactose malabsorption Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0344911 BXGD007707 Left ventricular dilatation
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0349782 BXGD007954 Ischemic cardiomyopathy Cardiovascular Diseases
C0401146 BXGD008272 Constipation - functional Pathological Conditions, Signs and Symptoms
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0401151 BXGD008274 Chronic diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0858600 BXGD011182 Taste sweet
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1112601 BXGD011679 Hypertonic dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1689817 BXGD013489 Cardiomyopathy associated with another disorder Cardiovascular Diseases
C1847425 BXGD014865 Abnormal oral glucose tolerance
C1963165 BXGD016685 Malabsorption, CTCAE
C2004435 BXGD016871 Vascular insufficiency of intestine Digestive System Diseases; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2697503 BXGD017428 Glucagon-like Peptide-1 measurement
C3245525 BXGD018581 Familial renal glucosuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3495427 BXGD018984 Fanconi-Bickel Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3714753 BXGD019428 RETINOSCHISIS 1, X-LINKED, JUVENILE
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C4524092 BXGD023092 Chronic rhinosinusitis with nasal polyps
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003788 Phlororrhizin 436.41
BXGC0005915 Formononetin 268.27
BXGC0008184 Phloretin 274.27
BXGC0013363 Kushenol K 472.21
BXGC0016130 acerogenin B 298.16
BXGC0019748 Kuraidin 438.2
BXGC0028706 Kushenol I 454.2
BXGC0029662 Sophoraflavanone G 424.19
BXGC0038878 acerogenin A 298.16
BXGC0040336 Pterocarpin 298.08
BXGC0041994 nothofagin 436.14
BXGC0042332 acerogenin C 296.14
BXGC0044008 Maackiain 284.07
BXGC0044733 aceroside VII 476.24
BXGC0046505 Aceroside I 460.21
BXGC0050739 Kurarinone 438.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein