acompound

Showing entry for Tamarixetin

General Compound Information
BXGC Id	BXGC0008747
Compound Name	Tamarixetin
Structure
Formula	C16H12O7
InchiKey	FPLMIPQZHHQWHN-UHFFFAOYSA-N
SMILES	COC1=C(O)C=C(C=C1)C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1
Inchi	InChI=1S/C16H12O7/c1-22-11-3-2-7(4-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
IUPAC	3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
Molecular Weight	316.26
Pubchem Id	5281699
Chembl Id	CHEMBL226034

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50325674

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT019667	Aurora kinase B	reviewed	Kinase	AURKB	-	7390	-	-
reviewed	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	-	120	-	-
reviewed	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	-	20	-	-

CHEMBL

CHEMBL226034

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q04206	BXGT012754	Transcription factor p65	reviewed	Transcription factor	RELA	Inhibition	-	-	-
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	reviewed	Transcription factor	NFKB1	Inhibition	-	-	-
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	reviewed	Transcription factor	NFKB2	Inhibition	-	-	-
Q28731	BXGT013954	Thrombin	unreviewed	-	thrombin	TT	'='	16	s
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	IC50	'='	1215	nM
P04792	BXGT006264	Heat shock protein beta-1	reviewed	-	HSPB1	Activity	-	-	-
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	IC50	-	-	-
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	IC50	'='	120	nM
Q16678	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	IC50	'='	20	nM
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	25	%
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	3	%
Q28731	BXGT013954	Thrombin	unreviewed	-	thrombin	Activity	'='	7	g/L
Q86831	BXGT017584	Polyprotein II	unreviewed	-		Inhibition	'='	59	%
Q9QUK6	BXGT021375	Toll-like receptor 4	reviewed	-	Tlr4	Inhibition	-	-	-
Q28731	BXGT013954	Thrombin	unreviewed	-	thrombin	PT	'='	6	s
Q4QEW7	BXGT014876	Dihydroorotate dehydrogenase (fumarate)	unreviewed	-	DHODH	IC50	'='	93700	nM
Q02127	BXGT012635	Dihydroorotate dehydrogenase (quinone), mitochondrial	reviewed	Enzyme	DHODH	Inhibition	'='	29	%
P45983	BXGT010494	Mitogen-activated protein kinase 8	reviewed	Kinase	MAPK8	K	'='	4	10'5/M
Q28731	BXGT013954	Thrombin	unreviewed	-	thrombin	APTT	'='	49	s
Q4QEW7	BXGT014876	Dihydroorotate dehydrogenase (fumarate)	unreviewed	-	DHODH	Inhibition	'='	46	%
Q4QEW7	BXGT014876	Dihydroorotate dehydrogenase (fumarate)	unreviewed	-	DHODH	IC50	'='	100000	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00816	Fats and oils		Fats and oils
BXGF00948	Artemisia apiacea	Artemisia apiacea	Medicinal Plant
BXGF01097	Arisarum vulgare	Arisarum vulgare	Medicinal Plant
BXGF01927	Reaumuria mucronata	Reaumuria mucronata	Others
BXGF01951	Helianthus divaricatus	Helianthus divaricatus	Others
BXGF01975	Syringa vulgaris	Syringa vulgaris	Medicinal Plant
BXGF02036	Glycyrrhiza pallidiflora	Glycyrrhiza pallidiflora	Medicinal Plant
BXGF02115	Eucalyptus sieberiana	Eucalyptus sieberiana	Others
BXGF02156	Quercus gilva	Quercus gilva	Others
BXGF02261	Alphitonia macrocarpa	Alphitonia macrocarpa	Others
BXGF04271	Artemisia annua	Artemisia annua	Medicinal Plant
BXGF05100	Glossocalyx brevipes	Glossocalyx brevipes	Others
BXGF06293	Indigofera linnaei	Indigofera linnaei	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}