Showing entry for Toll-like receptor 4



                       
General Target Information
BXGT IdBXGT021375
Protein NameToll-like receptor 4
Uniport IdQ9QUK6
GeneTlr4
Gene Id21898
DomainLRR_8; TIR
Pfam PF13855   PF01582  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0007250 activation of NF-kappaB-inducing kinase activity
Biological Process GO:0014002 astrocyte development
Biological Process GO:0002322 B cell proliferation involved in immune response
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0071223 cellular response to lipoteichoic acid
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0032497 detection of lipopolysaccharide
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0050965 detection of temperature stimulus involved in sensory perception of pain
Biological Process GO:0007252 I-kappaB phosphorylation
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0002758 innate immune response-activating signal transduction
Biological Process GO:0032609 interferon-gamma production
Biological Process GO:0032611 interleukin-1 beta production
Biological Process GO:0060729 intestinal epithelial structure maintenance
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:0031663 lipopolysaccharide-mediated signaling pathway
Biological Process GO:0042116 macrophage activation
Biological Process GO:0045576 mast cell activation
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0002755 MyD88-dependent toll-like receptor signaling pathway
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0032689 negative regulation of interferon-gamma production
Biological Process GO:0032700 negative regulation of interleukin-17 production
Biological Process GO:0032707 negative regulation of interleukin-23 production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:0002537 nitric oxide production involved in inflammatory response
Biological Process GO:0006909 phagocytosis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
Biological Process GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process GO:0032722 positive regulation of chemokine production
Biological Process GO:1900017 positive regulation of cytokine production involved in inflammatory response
Biological Process GO:0043388 positive regulation of DNA binding
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032727 positive regulation of interferon-alpha production
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032733 positive regulation of interleukin-10 production
Biological Process GO:0032735 positive regulation of interleukin-12 production
Biological Process GO:0032736 positive regulation of interleukin-13 production
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0032732 positive regulation of interleukin-1 production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0010838 positive regulation of keratinocyte proliferation
Biological Process GO:0050671 positive regulation of lymphocyte proliferation
Biological Process GO:0043032 positive regulation of macrophage activation
Biological Process GO:0060907 positive regulation of macrophage cytokine production
Biological Process GO:1904466 positive regulation of matrix metallopeptidase secretion
Biological Process GO:0045348 positive regulation of MHC class II biosynthetic process
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Biological Process GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
Biological Process GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
Biological Process GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Process GO:1903223 positive regulation of oxidative stress-induced neuron death
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0010572 positive regulation of platelet activation
Biological Process GO:1903428 positive regulation of reactive oxygen species biosynthetic process
Biological Process GO:0032874 positive regulation of stress-activated MAPK cascade
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0002730 regulation of dendritic cell cytokine production
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0051930 regulation of sensory perception of pain
Biological Process GO:1904467 regulation of tumor necrosis factor secretion
Biological Process GO:0009617 response to bacterium
Biological Process GO:0045471 response to ethanol
Biological Process GO:0070542 response to fatty acid
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0034142 toll-like receptor 4 signaling pathway
Biological Process GO:0002224 toll-like receptor signaling pathway
Biological Process GO:0035666 TRIF-dependent toll-like receptor signaling pathway
molecular function GO:0042802 identical protein binding
molecular function GO:0001530 lipopolysaccharide binding
molecular function GO:0001875 lipopolysaccharide immune receptor activity
molecular function GO:0050135 NAD(P)+ nucleosidase activity
molecular function GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
molecular function GO:0043548 phosphatidylinositol 3-kinase binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0038023 signaling receptor activity
molecular function GO:0005102 signaling receptor binding
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0005769 early endosome
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0031226 intrinsic component of plasma membrane
cellular component GO:0046696 lipopolysaccharide receptor complex
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0001891 phagocytic cup
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
cellular component GO:0001726 ruffle
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002605 Adenosine 267.24
BXGC0006466 Oleanolic acid 456.71
BXGC0008747 Tamarixetin 316.26
BXGC0011627 Glycyrrhetic acid 470.69
BXGC0013582 Curcumin 368.13
BXGC0018397 beta-1,4-mannan 180.06
BXGC0024810 curcumin 368.13
BXGC0026183 Sentulic Acid 470.34
BXGC0033502 3-Oxoolean-12-En-27-Oic Acid 454.34
BXGC0035226 Betulinic Acid 456.36
BXGC0047088 Ursolic Acid 456.36
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein