Showing entry for Dihydroorotate dehydrogenase (quinone), mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012635
Protein NameDihydroorotate dehydrogenase (quinone), mitochondrial
Uniport IdQ02127
GeneDHODH
Gene Id1723
DomainDHO_dh
Pfam PF01180  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00240 Pyrimidine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Biological Process GO:0044205 'de novo' UMP biosynthetic process
Biological Process GO:0007565 female pregnancy
Biological Process GO:0007595 lactation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0046134 pyrimidine nucleoside biosynthetic process
Biological Process GO:0009220 pyrimidine ribonucleotide biosynthetic process
Biological Process GO:0090140 regulation of mitochondrial fission
Biological Process GO:0031000 response to caffeine
Biological Process GO:0042493 response to drug
Biological Process GO:1903576 response to L-arginine
Biological Process GO:0042594 response to starvation
molecular function GO:0004152 dihydroorotate dehydrogenase activity
molecular function GO:0008144 drug binding
molecular function GO:0010181 FMN binding
molecular function GO:0048039 ubiquinone binding
cellular component GO:0005829 cytosol
cellular component GO:0016021 integral component of membrane
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-500753 Pyrimidine biosynthesis
R-HSA-8956320 Nucleobase biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002873 BXGD000133 Anemia of chronic disease Hemic and Lymphatic Diseases
C0002875 BXGD000135 Cooley's anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008297 BXGD000522 Choanal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013592 BXGD000857 Ectropion Eye Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0016514 BXGD001066 Foot-and-Mouth Disease Infections; Animal Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0018129 BXGD001175 Graft Rejection
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019025 BXGD001267 Hemoglobin F Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0020523 BXGD001417 Immediate hypersensitivity Immune System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027814 BXGD002042 Neuritis, Autoimmune, Experimental Immune System Diseases; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0036323 BXGD002595 Schistosomiasis Infections
C0037889 BXGD002709 Hereditary spherocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039075 BXGD002788 Syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0085578 BXGD003190 Thalassemia Minor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0158761 BXGD003905 Radioulnar Synostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0239234 BXGD004974 Low set ears
C0265224 BXGD005472 Freeman-Sheldon syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265257 BXGD005486 Genee-Wiedemann syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C0265681 BXGD005565 Supernumerary vertebra Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266011 BXGD005605 Accessory nipple Skin and Connective Tissue Diseases
C0266037 BXGD005611 Peg-shaped teeth Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266292 BXGD005643 Congenital anomaly of the kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0271979 BXGD006283 Thalassemia Intermedia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0337428 BXGD007155 Fibrinogen assay
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0423110 BXGD008471 Downward slant of palpebral fissure
C0431890 BXGD008712 Hypoplasia of thumb Musculoskeletal Diseases
C0432333 BXGD008778 Abnormal dermatoglyphic pattern Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0456070 BXGD008863 Growth delay
C0521573 BXGD009143 Coloboma of eyelid Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0521736 BXGD009170 Lower eyelid ectropion Eye Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685381 BXGD009809 Congenital hypoplasia of radius Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0740404 BXGD009991 Limb defects
C0751753 BXGD010576 Carbamoyl-Phosphate Synthase I Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0812435 BXGD010849 Chromosome 11p deletion syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases; Nervous System Diseases; Endocrine System Diseases
C0863188 BXGD011275 Stage III Carcinoma of Stomach
C0877008 BXGD011325 Enzyme inhibition disorder
C0949116 BXGD011571 Congenital hypoplastic anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1275685 BXGD012092 Avellino corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332140 BXGD012489 Acrofacial Dysostosis Musculoskeletal Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1845447 BXGD014747 Cupped ears (finding)
C1849706 BXGD015079 Midgut malrotation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1858085 BXGD015770 Malar flattening
C1859778 BXGD015931 Postnatal growth retardation
C1860614 BXGD015992 ULNAR HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C3160909 BXGD018497 Autoimmune arthritis
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4021020 BXGD020521 Non-midline cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C4048329 BXGD021904 Immunosuppression
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4551649 BXGD023382 Congenital Dysplasia Of The Hip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4554601 BXGD023566 Amyloidosis cutis dyschromia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000203 Piperine 285.34
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0001868 Catechin 290.27
BXGC0001919 4,5-Di-O-caffeoylquinic acid 516.45
BXGC0002767 Apiumetrin 432.38
BXGC0003426 (-)-Kaur-16-en-19-oic acid 302.46
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0006306 Myricetin 318.24
BXGC0008747 Tamarixetin 316.26
BXGC0009196 Quercetin 4'-glucoside 464.38
BXGC0020848 cyclo(leucyl-prolyl) 210.14
BXGC0028307 cyclo(prolyl-valyl) 196.12
BXGC0035521 Cyclo(Ile-Pro-) 210.14
BXGC0038234 cyclo(phenylalanyl-prolyl) 244.12
BXGC0040850 artemisinine 282.15
BXGC0042373 N,N-Dimethyldodecan-1-Amine Oxide 229.24
BXGC0042700 ferulenol 366.22
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein