Showing entry for 2-Methoxy-1,4-Naphthoquinone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0014059
Compound Name2-Methoxy-1,4-Naphthoquinone
Structure
FormulaC11H8O3
InchiKeyOBGBGHKYJAOXRR-UHFFFAOYSA-N
SMILESCOC1=CC(=O)c2c(C1=O)cccc2
InchiInChI=1S/C11H8O3/c1-14-10-6-9(12)7-4-2-3-5-8(7)11(10)13/h2-6H,1H3
IUPAC2-methoxynaphthalene-1,4-dione
Molecular Weight188.05
Pubchem Id16871
Chembl IdCHEMBL106562
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 24775
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed IDO1 - 720 - -
reviewed BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA - 20400 - -
CHEMBL CHEMBL106562
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 23109 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 11220 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 18356 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 1412 nM
Q77YF9 BXGT016886 Protein Vpr unreviewed - vpr Potency - 22387 nM
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 IC50 '=' 720 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 3662 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 79432 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 35481 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 11582 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 39810 nM
Q4U254 BXGT014890 Protease unreviewed - protease IC50 '=' 26000 nM
P00784 BXGT005655 Papain reviewed - IC50 - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 6513 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 19952 nM
P01215 BXGT005743 Glycoprotein hormones alpha chain reviewed - CGA Potency - 31622 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 14125 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 12589 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 10000 nM
P9WPJ7 BXGT012457 Beta-carbonic anhydrase 1 reviewed - mtcA1 deltaTm '=' 0 K
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 18348 nM
P9WPJ9 BXGT012458 Carbonic anhydrase 2 reviewed - mtcA2 IC50 '=' 2300 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 28183 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 4109 nM
P9WPJ9 BXGT012458 Carbonic anhydrase 2 reviewed - mtcA2 Activity '=' 84 %
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Activity '=' 104 %
P9WPJ7 BXGT012457 Beta-carbonic anhydrase 1 reviewed - mtcA1 Activity '=' 62 %
P9WPJ9 BXGT012458 Carbonic anhydrase 2 reviewed - mtcA2 Imax '=' 40 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01087 Impatiens balsamina Impatiens balsamina Medicinal Plant
BXGF02293 Rubia yunnanensis Rubia yunnanensis Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease