Showing entry for Anandamide


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0032290
Compound NameAnandamide
Structure
FormulaC22H37NO2
InchiKeyLGEQQWMQCRIYKG-DOFZRALJSA-N
SMILESCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=NCCO)O
InchiInChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
IUPAC(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
Molecular Weight347.28
Pubchem Id5281969
Chembl IdCHEMBL15848
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB E7Y
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P50120 BXGT010773 Retinol-binding protein 2 reviewed RBP2 - - - - -
Binding DB 22988
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 11 - - -
reviewed BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 168 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 200
reviewed BXGT010599 Cannabinoid receptor 2 reviewed Cnr2 1480 - - -
reviewed BXGT021399 Cannabinoid receptor 2 reviewed Cnr2 >10000 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 89 - - -
reviewed BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 306 - - -
reviewed BXGT007836 Fatty acid-binding protein, liver reviewed Fabp1 111 - - -
reviewed BXGT012839 Fatty acid-binding protein 5 reviewed Fabp5 - - 100.3 -
reviewed BXGT010582 Cannabinoid receptor 1 reviewed Cnr1 - 39 - -
reviewed BXGT010582 Cannabinoid receptor 1 reviewed Cnr1 5400 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 61 - - -
reviewed BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 371 - - -
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 89 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 630
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 78 - - -
reviewed BXGT010599 Cannabinoid receptor 2 reviewed Cnr2 1926 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 22 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 5810 - - -
reviewed BXGT010599 Cannabinoid receptor 2 reviewed Cnr2 1930 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 5400 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 490
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 800 - - -
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 39.2 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 90 - - -
reviewed BXGT021399 Cannabinoid receptor 2 reviewed Cnr2 360 - - -
reviewed BXGT003934 Fatty-acid amide hydrolase 1 reviewed FAAH >10000 - - -
reviewed BXGT012211 Fatty-acid amide hydrolase 1 reviewed Faah 3000 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 - 40 - -
reviewed BXGT010582 Cannabinoid receptor 1 reviewed Cnr1 - 12000 - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 400 - - -
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 300 - - -
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 1800 - - -
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 72 - - -
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 70 - - -
reviewed BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 180 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 132 - - -
reviewed BXGT010582 Cannabinoid receptor 1 reviewed Cnr1 52 - - -
reviewed BXGT010582 Cannabinoid receptor 1 reviewed Cnr1 89 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 39 - - -
reviewed BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 >1000 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 285 - - -
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 169 - - -
reviewed BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 50 - - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 72 - - -
reviewed BXGT013681 Lanosterol 14-alpha demethylase reviewed Enzyme CYP51A1 - >200000 - -
reviewed BXGT003934 Fatty-acid amide hydrolase 1 reviewed FAAH - 3400 - -
reviewed BXGT008556 Cannabinoid receptor 1 reviewed Cnr1 - - - 15849
reviewed BXGT012211 Fatty-acid amide hydrolase 1 reviewed Faah - 11748.98 - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 16
CHEMBL CHEMBL15848
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 72 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 50 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Ki '=' 3000 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 630 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 70 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 78 nM
Q9QZN9 BXGT021399 Cannabinoid receptor 2 reviewed - Cnr2 Ki '=' 78 nM
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 5400 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 EC50 '=' 15848 nM
O08914 BXGT004045 Fatty-acid amide hydrolase 1 reviewed - Faah Activity - - -
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 35481 nM
O08914 BXGT004045 Fatty-acid amide hydrolase 1 reviewed - Faah Km '=' 15000 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 61 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Emax '=' 380 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 106 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 40 %
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Inhibition - - -
Q4U2R8 BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 Activity - - -
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Activity - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 72 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Activity '=' 1 uM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 IC50 '=' 40 nM
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 EC50 '=' 360 nM
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 89 nM
P34972 BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 Ki '=' 180 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 89 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 39 nM
P34972 BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 Ki '=' 371 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 25 nM
Q9QZN9 BXGT021399 Cannabinoid receptor 2 reviewed - Cnr2 Ki '=' 25 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 21 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 91 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 98 %
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 44668 nM
P34972 BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 Ki '=' 168 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 22 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 5810 nM
P47936 BXGT010599 Cannabinoid receptor 2 reviewed - Cnr2 Ki '=' 52 nM
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 52 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 97 %
P34972 BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 Ki '>' 1000 nM
Q9QZN9 BXGT021399 Cannabinoid receptor 2 reviewed - Cnr2 Ki '=' 360 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ratio '=' 0 -
Q9QZN9 BXGT021399 Cannabinoid receptor 2 reviewed - Cnr2 Ratio '=' 0 -
Q16850 BXGT013681 Lanosterol 14-alpha demethylase reviewed Enzyme CYP51A1 IC50 '>' 200000 nM
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH Activity - - -
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 28183 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 28183 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 300 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 33 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Rate of hydrolysis '=' 1 nM min-1 mg-1
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 43 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 102 %
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 pKb '=' 8 -
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 90 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 1 -
P34972 BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 Log Ki '=' 2 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Log Ki '=' 1 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 800 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 39 nM
P47936 BXGT010599 Cannabinoid receptor 2 reviewed - Cnr2 Ki '=' 1926 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 169 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 39810 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '>' 1180 nM
Q9QZN9 BXGT021399 Cannabinoid receptor 2 reviewed - Cnr2 Ki '>' 1180 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah IC50 '=' 11748 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 285 nM
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 IC50 '=' 12000 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 78 nM
P47936 BXGT010599 Cannabinoid receptor 2 reviewed - Cnr2 Ki '=' 1930 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Emax '=' 54 %
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 490 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 58 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 10000 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 76 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 70 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Vmax '=' 1 nM min-1 mg-1
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 85 %
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 200 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Km '=' 2780 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 282 nM
Q9QZN9 BXGT021399 Cannabinoid receptor 2 reviewed - Cnr2 Ki '=' 282 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 87 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Relative rate of hydrolysis '=' 87 %
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 1800 nM
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 IC50 '=' 39 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 28183 nM
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH Ki '>' 10000 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 132 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 5400 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 400 nM
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH IC50 '=' 3400 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Affinity '=' 19 %
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Emax '=' 61 %
Q8HY88 BXGT018198 Potassium channel subfamily K member 2 unreviewed - KCNK2 IC50 '=' 1000 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 141 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 15 nM
P47746 BXGT010582 Cannabinoid receptor 1 reviewed - Cnr1 Emax '=' 68 %
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 11 nM
P47936 BXGT010599 Cannabinoid receptor 2 reviewed - Cnr2 Ki '>' 1000 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 70794 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 EC50 '=' 69 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki '=' 89 nM
Q9WUD2 BXGT021939 Transient receptor potential cation channel subfamily V member 2 reviewed - Trpv2 IC50 '=' 960 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah T1/2 '=' 0 hr
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH IC50 '=' 4100 nM
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH T1/2 '=' 0 hr
Q9WUD2 BXGT021939 Transient receptor potential cation channel subfamily V member 2 reviewed - Trpv2 IC50 '=' 8600 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '>' 1000 nM
P20272 BXGT008556 Cannabinoid receptor 1 reviewed - Cnr1 Ki '=' 74 nM
P34972 BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 Ki '=' 160 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00787 Yellow pond-lily Nuphar lutea Herbs and Spices
BXGF01199 Shuteria involucrata var. vestita Shuteria involucrata var. vestita Others
BXGF01275 Euphorbia kamerunica Euphorbia kamerunica Medicinal Plant
BXGF01573 Eria foetida Eria foetida Others
BXGF01816 Agave aurea Agave aurea Others
BXGF01988 Encephalartos altensteinii Encephalartos altensteinii Human Edible Plant
BXGF02172 Cupressus lawsoniana Cupressus lawsoniana Others
BXGF02264 Crinum erubescens Crinum erubescens Others
BXGF02374 Pentzia incana Pentzia incana Others
BXGF02429 Kobresia nepalensis Kobresia nepalensis Medicinal Plant
BXGF02486 Pronephrium triphyllum Pronephrium triphyllum Others
BXGF02622 Excoecaria oppositifolia Excoecaria oppositifolia Human Edible Plant
BXGF02722 Grindelia acutifolia Grindelia acutifolia Others
BXGF02809 Prangos pabularia Prangos pabularia Medicinal Plant
BXGF02893 Trifolium subterraneum Trifolium subterraneum Medicinal Plant
BXGF02923 Euphorbia marginata Euphorbia marginata Medicinal Plant
BXGF02972 Emilia sonchifolia Emilia sonchifolia Medicinal Plant
BXGF02990 Crataegus davisii Crataegus davisii Others
BXGF03002 Gardenia collinsae Gardenia collinsae Others
BXGF03041 Callistemon viminalis Callistemon viminalis Others
BXGF03061 Pausinystalia mayumbensis Pausinystalia mayumbensis Others
BXGF03074 Ajuga spectabilis Ajuga spectabilis Others
BXGF03098 Cissus pallidiflorus Cissus pallidiflorus Others
BXGF03112 Ursinia abrotanifolia Ursinia abrotanifolia Others
BXGF03123 Selliguea feei Selliguea feei Others
BXGF03133 Jungermannia hyalina Jungermannia hyalina Others
BXGF03155 Melampodium heterophyllum Melampodium heterophyllum Others
BXGF03165 Simaba multiflora Simaba multiflora Others
BXGF03181 Baphia nitida Baphia nitida Medicinal Plant
BXGF03191 Litsea pulchella Litsea pulchella Others
BXGF03214 Astragalus tragacantha Astragalus tragacantha Others
BXGF03228 Teucrium oxylepis Teucrium oxylepis Others
BXGF03248 Ligularia muliensis Ligularia muliensis Others
BXGF03261 Alstroemeria revoluta Alstroemeria revoluta Medicinal Plant
BXGF03278 Marrubium alysson Marrubium alysson Others
BXGF03295 Achillea macrophylla Achillea macrophylla Others
BXGF03481 Eupatorium havanense Eupatorium havanense Others
BXGF04318 Litsea aciculata Litsea aciculata Others
BXGF04683 Gymnosporia senegalensis Gymnosporia senegalensis Medicinal Plant
BXGF05150 Stevia chamaedrys Stevia chamaedrys Others
BXGF06073 Trillium camschatcense Trillium camschatcense Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease