protein

Showing entry for Fatty-acid amide hydrolase 1

General Target Information
BXGT Id	BXGT003934
Protein Name	Fatty-acid amide hydrolase 1
Uniport Id	O00519
Gene	FAAH
Gene Id	2166
Domain	Amidase
Pfam	PF01425
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.6 Nervous system	hsa04723	Retrograde endocannabinoid signaling

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0019369	arachidonic acid metabolic process
Biological Process	GO:0009062	fatty acid catabolic process
Biological Process	GO:0052651	monoacylglycerol catabolic process
molecular function	GO:0047372	acylglycerol lipase activity
molecular function	GO:0004040	amidase activity
molecular function	GO:0103073	anandamide amidohydrolase activity
molecular function	GO:0017064	fatty acid amide hydrolase activity
molecular function	GO:0102077	oleamide hydrolase activity
cellular component	GO:0005856	cytoskeleton
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0031090	organelle membrane

Reactome

Pathway Id	Pathway Name
R-HSA-1430728	Metabolism
R-HSA-2142753	Arachidonic acid metabolism
R-HSA-556833	Metabolism of lipids
R-HSA-8978868	Fatty acid metabolism

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000737	BXGD000005	Abdominal Pain	Pathological Conditions, Signs and Symptoms
C0001418	BXGD000050	Adenocarcinoma	Neoplasms
C0001973	BXGD000095	Alcoholic Intoxication, Chronic	Chemically-Induced Disorders; Mental Disorders
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002895	BXGD000152	Anemia, Sickle Cell	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003125	BXGD000179	Anorexia Nervosa	Mental Disorders
C0003431	BXGD000190	Antisocial Personality Disorder	Mental Disorders
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003469	BXGD000195	Anxiety Disorders	Mental Disorders
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0004352	BXGD000269	Autistic Disorder	Mental Disorders
C0004936	BXGD000295	Mental disorders	Mental Disorders
C0005586	BXGD000315	Bipolar Disorder	Mental Disorders
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006370	BXGD000394	Bulimia	Pathological Conditions, Signs and Symptoms
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0006870	BXGD000416	Cannabis Dependence	Chemically-Induced Disorders; Mental Disorders
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007570	BXGD000467	Celiac Disease	Digestive System Diseases; Nutritional and Metabolic Diseases
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009806	BXGD000633	Constipation	Pathological Conditions, Signs and Symptoms
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884	BXGD000762	Diabetic Retinopathy	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0013146	BXGD000801	Drug abuse	Chemically-Induced Disorders; Mental Disorders
C0013170	BXGD000802	Drug habituation	Chemically-Induced Disorders; Mental Disorders
C0013222	BXGD000805	Drug Use Disorders	Chemically-Induced Disorders; Mental Disorders
C0015672	BXGD001011	Fatigue	Pathological Conditions, Signs and Symptoms
C0016169	BXGD001048	pathologic fistula	Pathological Conditions, Signs and Symptoms
C0017178	BXGD001102	Gastrointestinal Diseases	Digestive System Diseases
C0017601	BXGD001125	Glaucoma	Eye Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0019337	BXGD001319	Heroin Dependence	Chemically-Induced Disorders; Mental Disorders
C0020179	BXGD001363	Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020429	BXGD001378	Hyperalgesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0021125	BXGD001483	Impulsive Behavior	Behavior and Behavior Mechanisms
C0022104	BXGD001529	Irritable Bowel Syndrome	Digestive System Diseases
C0022333	BXGD001534	Jacksonian Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0024809	BXGD001808	Marijuana Abuse	Chemically-Induced Disorders; Mental Disorders
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0027497	BXGD001993	Nausea	Pathological Conditions, Signs and Symptoms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027765	BXGD002033	nervous system disorder	Nervous System Diseases
C0027796	BXGD002037	Neuralgia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028043	BXGD002066	Nicotine Dependence	Chemically-Induced Disorders; Mental Disorders
C0028047	BXGD002067	Nicotine withdrawal	Chemically-Induced Disorders; Mental Disorders
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756	BXGD002083	Obesity, Morbid	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029231	BXGD002125	Organic Mental Disorders, Substance-Induced	Chemically-Induced Disorders; Mental Disorders
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0030201	BXGD002194	Pain, Postoperative	Pathological Conditions, Signs and Symptoms
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0031117	BXGD002285	Peripheral Neuropathy	Nervous System Diseases
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032962	BXGD002382	Pregnancy Complications	Female Urogenital Diseases and Pregnancy Complications
C0033831	BXGD002431	Psychological pseudocyesis	Behavior and Behavior Mechanisms
C0035222	BXGD002513	Respiratory Distress Syndrome, Adult	Respiratory Tract Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038436	BXGD002755	Post-Traumatic Stress Disorder	Mental Disorders
C0038580	BXGD002771	Substance Dependence	Chemically-Induced Disorders; Mental Disorders
C0038586	BXGD002772	Substance Use Disorders	Chemically-Induced Disorders; Mental Disorders
C0038587	BXGD002773	Substance Withdrawal Syndrome	Chemically-Induced Disorders; Mental Disorders
C0041696	BXGD002932	Unipolar Depression	Mental Disorders
C0042963	BXGD003018	Vomiting	Pathological Conditions, Signs and Symptoms
C0085281	BXGD003152	Addictive Behavior	Behavior and Behavior Mechanisms
C0085625	BXGD003212	Hypoalgesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0085762	BXGD003251	Alcohol abuse	Chemically-Induced Disorders; Mental Disorders
C0086132	BXGD003264	Depressive Symptoms	Behavior and Behavior Mechanisms
C0086189	BXGD003268	Drug Withdrawal Symptoms	Chemically-Induced Disorders; Mental Disorders
C0087169	BXGD003321	Withdrawal Symptoms	Chemically-Induced Disorders; Mental Disorders
C0149931	BXGD003388	Migraine Disorders	Nervous System Diseases
C0149958	BXGD003395	Complex partial seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0152020	BXGD003519	Gastroparesis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0155616	BXGD003805	Secondary hypertension	Cardiovascular Diseases
C0178782	BXGD004034	Orofacial Pain	Pathological Conditions, Signs and Symptoms
C0200638	BXGD004043	Eosinophil count procedure
C0232717	BXGD004558	Rectal sensation
C0233514	BXGD004584	Abnormal behavior	Behavior and Behavior Mechanisms
C0234533	BXGD004687	Generalized seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535	BXGD004688	Clonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235031	BXGD004714	Neurologic Symptoms	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236969	BXGD004842	Substance-Related Disorders	Chemically-Induced Disorders; Mental Disorders
C0237123	BXGD004845	Alcohol or Other Drugs use
C0242339	BXGD005150	Dyslipidemias	Nutritional and Metabolic Diseases
C0242510	BXGD005173	Drug usage	Chemically-Induced Disorders; Mental Disorders
C0270824	BXGD006113	Visual seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844	BXGD006115	Tonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846	BXGD006116	Epileptic drop attack	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278134	BXGD006498	Absence of sensation	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0338106	BXGD007167	Adenocarcinoma of colon	Digestive System Diseases; Neoplasms
C0342788	BXGD007552	Renal carnitine transport defect	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0391976	BXGD008022	Pain Disorder	Mental Disorders
C0393574	BXGD008095	Huntington Disease, Late Onset	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0422850	BXGD008457	Seizures, Somatosensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852	BXGD008458	Seizures, Auditory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853	BXGD008459	Olfactory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854	BXGD008460	Gustatory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855	BXGD008461	Vertiginous seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424139	BXGD008520	Anxiety and fear
C0424295	BXGD008524	Hyperactive behavior	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0442874	BXGD008814	Neuropathy	Nervous System Diseases
C0457949	BXGD008899	Chronic low back pain	Pathological Conditions, Signs and Symptoms
C0494475	BXGD009030	Tonic - clonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497397	BXGD009063	Anorexia and bulimia syndrome
C0520909	BXGD009123	Postoperative Nausea and Vomiting	Pathological Conditions, Signs and Symptoms
C0521991	BXGD009187	Symptoms of stress
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C0525041	BXGD009254	Neurobehavioral Manifestations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0525045	BXGD009255	Mood Disorders	Mental Disorders
C0549393	BXGD009374	Alcohol problem
C0559031	BXGD009464	Functional Gastrointestinal Disorders	Digestive System Diseases
C0563625	BXGD009484	Agnosia for Pain	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0574785	BXGD009506	Lower Urinary Tract Symptoms	Pathological Conditions, Signs and Symptoms
C0596240	BXGD009638	Cancer Pain	Pathological Conditions, Signs and Symptoms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0740858	BXGD010012	Substance abuse problem	Chemically-Induced Disorders; Mental Disorders
C0747845	BXGD010184	early pregnancy
C0751056	BXGD010306	Non-epileptic convulsion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110	BXGD010318	Single Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123	BXGD010326	Atonic Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751207	BXGD010348	Akinetic-Rigid Variant of Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0751208	BXGD010349	Juvenile Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0751494	BXGD010472	Convulsive Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495	BXGD010473	Seizures, Focal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496	BXGD010474	Seizures, Sensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0860603	BXGD011236	Anxiety symptoms
C0877008	BXGD011325	Enzyme inhibition disorder
C0878544	BXGD011368	Cardiomyopathies	Cardiovascular Diseases
C1257861	BXGD011811	Colonic Inertia	Pathological Conditions, Signs and Symptoms
C1263846	BXGD011897	Attention deficit hyperactivity disorder	Mental Disorders
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1510472	BXGD013170	Drug Dependence	Chemically-Induced Disorders; Mental Disorders
C1510586	BXGD013176	Autism Spectrum Disorders	Mental Disorders
C1533217	BXGD013313	Methamphetamine dependence	Chemically-Induced Disorders; Mental Disorders
C1561826	BXGD013364	Overweight and obesity
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1723764	BXGD013706	Chronic Prostatitis with Chronic Pelvic Pain Syndrome	Male Urogenital Diseases
C1832661	BXGD013866	ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1855179	BXGD015468	CATARACT, ANTERIOR POLAR	Eye Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C2267227	BXGD017015	Bulimia Nervosa	Mental Disorders
C2362324	BXGD017091	Pediatric Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2939186	BXGD018176	Disturbance in mood	Mental Disorders
C3160814	BXGD018477	Cannabis use
C3495874	BXGD019008	Nonepileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3496069	BXGD019017	cocaine use
C3854611	BXGD019840	Anticipatory nausea
C3873567	BXGD019863	Peripheral neuropathy due to and following chemotherapy	Nervous System Diseases
C4048158	BXGD021890	Convulsions	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316881	BXGD022709	Prescription Drug Abuse	Chemically-Induced Disorders; Mental Disorders
C4316903	BXGD022711	Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109	BXGD022725	Epileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123	BXGD022727	Myoclonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436	BXGD022962	Generalized Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4552766	BXGD023523	Miscarriage	Female Urogenital Diseases and Pregnancy Complications
C4721453	BXGD023744	Peripheral Nervous System Diseases	Nervous System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000497	Vanillin		152.15
BXGC0002748	Salicaldehyde		122.12
BXGC0002779	Dodecan-1-al		186.33
BXGC0003852	Nigrin B		506.47
BXGC0004144	Heptanal		114.19
BXGC0004552	Cuminaldehyde		148.21
BXGC0005659	Arachidonic acid		304.47
BXGC0006908	Geranial		152.24
BXGC0007011	(R)-Perillaldehyde		150.22
BXGC0007581	(R)-Citronellal		154.25
BXGC0008167	Chrysin		254.24
BXGC0009122	Zein		174.19
BXGC0010962	Macamide B		345.56
BXGC0013727	(Z)-Heptadec-8-Enal		252.25
BXGC0014695	Loratadine		382.14
BXGC0024591	Oleamide		281.27
BXGC0028001	Beta-Lapachone		242.09
BXGC0030685	Physostigmine		275.16
BXGC0032290	Anandamide		347.28
BXGC0034894	Oleic Acid		282.26
BXGC0041544	Phenprobamate		179.09
BXGC0041560	Thiram		239.99
BXGC0042668	2-Nonenal		140.12
BXGC0043854	Propoxur		209.11
BXGC0044258	Olealdehyde		266.26
BXGC0051081	caryophyllene		204.19

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}