Showing entry for Lanosterol 14-alpha demethylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013681
Protein NameLanosterol 14-alpha demethylase
Uniport IdQ16850
GeneCYP51A1
Gene Id1595
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00100 Steroid biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:1900222 negative regulation of amyloid-beta clearance
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0050709 negative regulation of protein secretion
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0006694 steroid biosynthetic process
Biological Process GO:0016125 sterol metabolic process
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0004497 monooxygenase activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0008398 sterol 14-demethylase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-191273 Cholesterol biosynthesis
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006840 BXGD000409 Candidiasis Infections
C0009186 BXGD000590 Coccidioidomycosis Infections
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0015624 BXGD001005 Fanconi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0016952 BXGD001085 Galactosemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0022283 BXGD001533 Incontinentia Pigmenti Achromians Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0023980 BXGD001725 Longevity
C0026946 BXGD001951 Mycoses Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033740 BXGD002416 Protozoan Infections Infections
C0041234 BXGD002901 Chagas Disease Infections
C0041296 BXGD002903 Tuberculosis Infections
C0085436 BXGD003177 Meningitis, Cryptococcal Infections; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0153252 BXGD003616 Systemic candidiasis Infections
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220724 BXGD004332 CONSTRICTING BANDS, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0221244 BXGD004418 Seborrheic dermatitis of scalp Skin and Connective Tissue Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238013 BXGD004855 Invasive aspergillosis Infections
C0268151 BXGD005838 Classical galactosemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0276653 BXGD006438 Invasive Pulmonary Aspergillosis Infections; Respiratory Tract Diseases
C0300934 BXGD006827 Primary Amebic Meningoencephalitis Infections; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0423775 BXGD008507 Scurfiness of scalp Skin and Connective Tissue Diseases
C0877008 BXGD011325 Enzyme inhibition disorder
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931187 BXGD017971 Nephropathic cystinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2931826 BXGD018069 Potassium aggravated myotonia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2936791 BXGD018138 Antley-Bixler Syndrome, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001325 Progesterone 314.46
BXGC0005659 Arachidonic acid 304.47
BXGC0006990 Lanosterol 426.72
BXGC0008676 Haem 616.49
BXGC0020800 Testosterone 288.21
BXGC0029355 Pregnenolone 316.24
BXGC0032290 Anandamide 347.28
BXGC0038316 Cholesterol 386.35
BXGC0049391 Betadex 1134.37
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein