Showing entry for 4'-Methoxyflavone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0037016
Compound Name4'-Methoxyflavone
Structure
FormulaC16H12O3
InchiKeyOMICQBVLCVRFGN-UHFFFAOYSA-N
SMILESCOc1ccc(cc1)c1cc(=O)c2c(o1)cccc2
InchiInChI=1S/C16H12O3/c1-18-12-8-6-11(7-9-12)16-10-14(17)13-4-2-3-5-15(13)19-16/h2-10H,1H3
IUPAC2-(4-methoxyphenyl)chromen-4-one
Molecular Weight252.08
Pubchem Id77793
Chembl IdCHEMBL16312
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB A63
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q9H2K2 BXGT020454 Poly [ADP-ribose] polymerase tankyrase-2 reviewed TNKS2 - - - - -
Binding DB 50310189
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT019704 NACHT, LRR and PYD domains-containing protein 3 reviewed NLRP3 - 31000 - -
reviewed BXGT019704 NACHT, LRR and PYD domains-containing protein 3 reviewed NLRP3 - 5400 - -
reviewed BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA 2640 - - -
reviewed BXGT009172 Amine oxidase [flavin-containing] B reviewed MAOB 1800 - - -
reviewed BXGT009172 Amine oxidase [flavin-containing] B reviewed MAOB - 27870 - -
CHEMBL CHEMBL16312
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1995 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 28183 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 11220 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 11577 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 2818 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 8912 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 39810 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 22387 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 158489 nM
P22460 BXGT008774 Potassium voltage-gated channel subfamily A member 5 reviewed Ion channel KCNA5 IC50 '=' 9000 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 31622 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 7307 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Inhibition '=' 40 %
Q05769 BXGT012834 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Inhibition '=' 38 %
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 6012 nM
O95271 BXGT005369 Poly [ADP-ribose] polymerase tankyrase-1 reviewed - TNKS IC50 '=' 71 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 31622 nM
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 reviewed - NLRP3 IC50 '=' 31000 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 19952 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Activity - - -
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 12589 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 14125 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 12589 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 28183 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 44668 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 79432 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 21900 nM
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 reviewed - NLRP3 IC50 '=' 5400 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 8912 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20587 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 25118 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 12589 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 10000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 5623 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency - 12589 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 1995 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 10000 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 1000 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 2511 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 3981 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '=' 27870 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 201 %
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 reviewed Nuclear receptor NR0B1 IC50 '>' 67535 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition - - -
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 11220 nM
O95271 BXGT005369 Poly [ADP-ribose] polymerase tankyrase-1 reviewed - TNKS IC50 '=' 70 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 105 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04734 Cullen corylifolium Cullen corylifolium Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease