Showing entry for Poly [ADP-ribose] polymerase tankyrase-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020454
Protein NamePoly [ADP-ribose] polymerase tankyrase-2
Uniport IdQ9H2K2
GeneTNKS2
Gene Id80351
DomainAnk; Ank_2; Ank_4; Ank_5; PARP; SAM_2
Pfam PF00023   PF12796   PF00644   PF07647  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:1904357 negative regulation of telomere maintenance via telomere lengthening
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:1904355 positive regulation of telomere capping
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:0006471 protein ADP-ribosylation
Biological Process GO:0070213 protein auto-ADP-ribosylation
Biological Process GO:0070198 protein localization to chromosome, telomeric region
Biological Process GO:0070212 protein poly-ADP-ribosylation
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0040014 regulation of multicellular organism growth
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0019899 enzyme binding
molecular function GO:0046872 metal ion binding
molecular function GO:0003950 NAD+ ADP-ribosyltransferase activity
molecular function GO:1990404 protein ADP-ribosylase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000139 Golgi membrane
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005635 nuclear envelope
cellular component GO:0005634 nucleus
cellular component GO:0000242 pericentriolar material
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-392499 Metabolism of proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-6807070 PTEN Regulation
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0392006 BXGD008025 Unilateral cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002071 Apigenin 270.24
BXGC0003705 Chloride 35.45
BXGC0003776 Flavones 222.24
BXGC0004266 2-Propanol 60.1
BXGC0004588 trans-Cinnamic acid 148.16
BXGC0005766 3',4',7-Trihydroxyflavone 270.24
BXGC0006125 Nicotinamide 122.12
BXGC0006635 Luteolin 286.24
BXGC0021234 Quinazolinone 146.05
BXGC0035557 Pratol 268.07
BXGC0037016 4'-Methoxyflavone 252.08
BXGC0038577 Magnolol 266.13
BXGC0045681 SR-01000500270 362.17
BXGC0048244 1H-Quinolin-2-One 145.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein