Showing entry for Lysosomal acid glucosylceramidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006140
Protein NameLysosomal acid glucosylceramidase
Uniport IdP04062
GeneGBA
Gene Id2629
DomainGlyco_hydro_30; Glyco_hydro_30C
Pfam PF02055   PF17189  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00511 Other glycan degradation
1. Metabolism 1.3 Lipid metabolism hsa00600 Sphingolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1905037 autophagosome organization
Biological Process GO:0006914 autophagy
Biological Process GO:1901805 beta-glucoside catabolic process
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0046513 ceramide biosynthetic process
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0006680 glucosylceramide catabolic process
Biological Process GO:0006687 glycosphingolipid metabolic process
Biological Process GO:0030259 lipid glycosylation
Biological Process GO:0007040 lysosome organization
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0043407 negative regulation of MAP kinase activity
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
Biological Process GO:1904457 positive regulation of neuronal action potential
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0043243 positive regulation of protein-containing complex disassembly
Biological Process GO:0035307 positive regulation of protein dephosphorylation
Biological Process GO:1903061 positive regulation of protein lipidation
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
Biological Process GO:0032268 regulation of cellular protein metabolic process
Biological Process GO:1905165 regulation of lysosomal protein catabolic process
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0032006 regulation of TOR signaling
Biological Process GO:0033561 regulation of water loss via skin
Biological Process GO:0071548 response to dexamethasone
Biological Process GO:0043627 response to estrogen
Biological Process GO:0009268 response to pH
Biological Process GO:0033574 response to testosterone
Biological Process GO:0097066 response to thyroid hormone
Biological Process GO:0043589 skin morphogenesis
Biological Process GO:0046512 sphingosine biosynthetic process
Biological Process GO:0023021 termination of signal transduction
molecular function GO:0004348 glucosylceramidase activity
molecular function GO:0046527 glucosyltransferase activity
molecular function GO:0016787 hydrolase activity
molecular function GO:0005124 scavenger receptor binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0050295 steryl-beta-glucosidase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0070062 extracellular exosome
cellular component GO:0019898 extrinsic component of membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0005802 trans-Golgi network
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011253 BXGD000706 Delusions Behavior and Behavior Mechanisms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013592 BXGD000857 Ectropion Eye Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014378 BXGD000912 Enterovirus Infections Infections
C0014550 BXGD000930 Myoclonic Epilepsy Nervous System Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016663 BXGD001071 Pathological fracture Wounds and Injuries
C0017205 BXGD001105 Gaucher Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020532 BXGD001420 Hypersplenism Hemic and Lymphatic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0020758 BXGD001467 Congenital ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023794 BXGD001700 Lipoidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026269 BXGD001897 Mitral Valve Stenosis Cardiovascular Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027543 BXGD001997 Avascular necrosis of bone Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028064 BXGD002068 Niemann-Pick Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029464 BXGD002161 Osteosclerosis Musculoskeletal Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031039 BXGD002274 Pericardial effusion Cardiovascular Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037268 BXGD002675 Skin Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037771 BXGD002702 Paraparesis, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0039373 BXGD002809 Tay-Sachs Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041105 BXGD002895 Trismus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042025 BXGD002950 Urinary Stress Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0079154 BXGD003065 Congenital Nonbullous Ichthyosiform Erythroderma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079583 BXGD003082 Ichthyosiform Erythroderma, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085623 BXGD003210 Akinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0085660 BXGD003228 Aseptic necrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0086439 BXGD003284 Hypokinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151564 BXGD003440 Cogwheel Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151669 BXGD003457 Increased antibody level in blood
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151818 BXGD003480 Opisthotonus Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0206307 BXGD004175 Canavan Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0231688 BXGD004510 Gait, Shuffling Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233763 BXGD004611 Hallucinations, Visual Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240341 BXGD005032 Micrographia
C0240379 BXGD005033 Open mouth (finding)
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0240735 BXGD005052 Personality Change Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0241144 BXGD005080 Petechiae of skin Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0241700 BXGD005108 Voice Fatigue Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0262431 BXGD005242 Compression fracture of vertebral column Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Wounds and Injuries
C0265962 BXGD005590 Ichthyosis linearis circumflexa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0268250 BXGD005868 Gaucher Disease, Type 2 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268251 BXGD005869 Gaucher Disease, Type 3 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0271270 BXGD006178 Oculovestibuloauditory syndrome Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0271385 BXGD006193 Horizontal Nystagmus Eye Diseases; Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0282513 BXGD006808 Primary Progressive Aphasia (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340968 BXGD007377 Deficiency of pyruvate kinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0348489 BXGD007875 Other sphingolipidosis Nutritional and Metabolic Diseases
C0349588 BXGD007933 Short stature
C0400979 BXGD008268 Obstruction of biliary tree Digestive System Diseases
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0410916 BXGD008452 Neonatal Death Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0423421 BXGD008484 Atrophic macular change
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0424448 BXGD008529 Mask-like facies Nervous System Diseases
C0426980 BXGD008599 Motor symptoms
C0428465 BXGD008629 Serum lipids high (finding)
C0428791 BXGD008635 Aortic valve calcification Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0455988 BXGD008860 Hydrops Fetalis, Non-Immune Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541764 BXGD009259 Delayed bone age
C0548883 BXGD009356 Low frustration tolerance Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0574002 BXGD009497 Edema of foot (finding) Pathological Conditions, Signs and Symptoms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0595939 BXGD009629 Stillbirth Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600452 BXGD009708 Hepatopulmonary Syndrome Digestive System Diseases; Respiratory Tract Diseases
C0686377 BXGD009834 CNS metastases Neoplasms; Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0747651 BXGD010175 Recurrent aspiration pneumonia Infections; Respiratory Tract Diseases
C0749379 BXGD010214 Thoracolumbar scoliosis Musculoskeletal Diseases
C0751378 BXGD010420 Neurologic Signs Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751772 BXGD010583 REM Sleep Behavior Disorder Nervous System Diseases; Mental Disorders
C0751779 BXGD010588 Action Myoclonus-Renal Failure Syndrome Nervous System Diseases
C0751783 BXGD010592 Lafora Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0813217 BXGD010854 Expressionless face Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0919718 BXGD011437 Calcification of mitral valve
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1096249 BXGD011612 Calcification of the aorta
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1276035 BXGD012100 Pena-Shokeir syndrome type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333295 BXGD012614 Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
C1333296 BXGD012615 Activated B-cell type diffuse large B-cell lymphoma
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1390474 BXGD012969 Increased susceptibility to fractures
C1408507 BXGD013038 Supranuclear ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1835884 BXGD014061 Triangular face
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1836830 BXGD014165 Developmental regression Mental Disorders
C1836904 BXGD014176 Spastic/hyperactive bladder
C1837388 BXGD014225 Abnormal pattern of respiration
C1837482 BXGD014237 Thoracic hypoplasia
C1840077 BXGD014434 Anteverted nostril
C1842704 BXGD014534 GAUCHER DISEASE, PERINATAL LETHAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1842714 BXGD014535 Desquamation of skin soon after birth
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846865 BXGD014845 Substantia nigra gliosis Pathological Conditions, Signs and Symptoms
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1850496 BXGD015147 Neuronal loss in central nervous system
C1851959 BXGD015251 Fluctuations in consciousness
C1851972 BXGD015253 Reticular hyperpigmentation
C1853237 BXGD015319 Isolated cases
C1853246 BXGD015323 Eversion of lower lip
C1854114 BXGD015383 Short nose
C1854301 BXGD015391 Motor delay Mental Disorders
C1854838 BXGD015438 Progressive neurologic deterioration Mental Disorders
C1854928 BXGD015443 Protuberant abdomen
C1855895 BXGD015557 Erlenmeyer flask deformity of the femurs
C1856476 BXGD015611 Gaucher Disease, Type Iiic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1856477 BXGD015612 Slowed horizontal saccades
C1856478 BXGD015613 Hypometric horizontal saccades
C1856507 BXGD015614 Bulbar signs
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1858430 BXGD015792 Death in infancy
C1868528 BXGD016503 Orthostatic hypotension due to autonomic dysfunction Nervous System Diseases; Cardiovascular Diseases
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1961835 BXGD016676 Gaucher Disease, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2364082 BXGD017123 Sense of smell impaired Nervous System Diseases
C2676021 BXGD017320 DEMENTIA, LEWY BODY, SUSCEPTIBILITY TO
C2826321 BXGD017789 Refractory Thrombocytopenia Hemic and Lymphatic Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2931585 BXGD018037 Gaucher-like disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3163801 BXGD018517 Abnormality of aortic arch
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3489733 BXGD018945 Oculomotor apraxia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C3494358 BXGD018961 Prodromal Symptoms Pathological Conditions, Signs and Symptoms
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3805715 BXGD019484 Short stepped shuffling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3887513 BXGD019887 Avascular necrosis Pathological Conditions, Signs and Symptoms
C4011788 BXGD020116 Behavioral variant of frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021790 BXGD020782 Abnormality of the skeletal system
C4023698 BXGD021247 Everted upper lip vermilion
C4024794 BXGD021421 Horizontal supranuclear gaze palsy
C4025758 BXGD021779 Abnormal myocardium morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4275179 BXGD022368 Young onset Parkinson disease Nervous System Diseases
C4285807 BXGD022455 Behavioral and psychological symptoms of dementia
C4316870 BXGD022707 Abnormality of the eye
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4531121 BXGD023189 Monotonic speech
C4551583 BXGD023361 Cerebral cortical atrophy
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553018 BXGD023532 Avascular Necrosis, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
C4553962 BXGD023553 Hyperkeratosis, CTCAE
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
C4721411 BXGD023735 Osteolysis Musculoskeletal Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000016 Butein 272.25
BXGC0000230 Ochratoxin A 403.81
BXGC0000340 Kaempferol 286.24
BXGC0000436 Glycerol 92.09
BXGC0000470 Chalconaringenin 272.25
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000653 1,2,3,4-Tetrahydro-2-methyl-b-carboline 186.25
BXGC0000681 Umbelliferone 162.14
BXGC0000709 Chiro-Inositol 180.16
BXGC0000964 6-Methylscutellarein 300.26
BXGC0001024 Cirsimaritin 314.29
BXGC0001742 Eupafolin 316.26
BXGC0001789 Silibinin 482.44
BXGC0001820 Osthol 244.29
BXGC0001994 Hyperin 464.38
BXGC0002052 Aesculetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0002374 Taurine 125.15
BXGC0002591 Potassium 39.1
BXGC0002797 Nodakenetic 246.26
BXGC0003249 5-Hexyl-2-methylpyridine 270.37
BXGC0003255 Lochnocarpol A 408.49
BXGC0003364 Cerebroside 299.49
BXGC0003472 1,3-Dimethylbenzene 106.17
BXGC0003705 Chloride 35.45
BXGC0004738 Myo-Inositol 180.16
BXGC0005018 5,7-Dimethoxycoumarin 206.19
BXGC0005049 4-Methylumbelliferyl acetate 218.21
BXGC0005442 Testosterone 288.42
BXGC0005611 Coclaurine 285.34
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0005703 Bergamottin 338.4
BXGC0005793 Baicalein 270.24
BXGC0005919 Biochanin A 284.27
BXGC0005982 Curcumin 368.38
BXGC0005989 Auraptene 298.38
BXGC0006291 Scopoletin 192.17
BXGC0006306 Myricetin 318.24
BXGC0006635 Luteolin 286.24
BXGC0007530 Folic acid 441.4
BXGC0008168 7-Methylchrysin 268.26
BXGC0008184 Phloretin 274.27
BXGC0008667 6-Prenylnaringenin 340.38
BXGC0008707 Isoliquiritigenin 256.25
BXGC0008958 Naringenin fructoside 272.26
BXGC0009649 Dihydrocapsaicin 307.43
BXGC0010010 3,8''-Biapigenin 538.46
BXGC0012460 [(9R,10R)-8,8-Dimethyl-10-(3-Methylbut-2-Enoyloxy)-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-9-Yl] (Z)-2-Methylbut-2-Enoate 426.17
BXGC0014086 Vicenin-2 594.16
BXGC0015733 6,7-Dimethoxy-3-(6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)-3H-2-Benzofuran-1-One 383.14
BXGC0015879 Chlorhexidine 504.2
BXGC0016028 Castanospermine 189.1
BXGC0016470 Camptothecin 348.11
BXGC0017498 Calystegine B2 175.08
BXGC0017596 Jatrorrhizine 338.14
BXGC0018345 (2S,3S,4R)-2-Hydroxymethylpiperidine-3,4-Diol 147.09
BXGC0018397 beta-1,4-mannan 180.06
BXGC0019164 Raloxifene 473.17
BXGC0019372 Demethylencecalin 218.09
BXGC0020800 Testosterone 288.21
BXGC0021716 (R)-Verapamil 454.28
BXGC0022039 N-Methyl-1-Deoxynojirimycin 177.1
BXGC0022806 1-(5-Thiophen-2-Ylthiophen-2-Yl)Ethanone 208
BXGC0023039 (10-Acetyloxy-8,8-Dimethyl-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-9-Yl) 3-Methylbutanoate 388.15
BXGC0025338 Fagomine 147.09
BXGC0025530 4-Ethyl-3-Methyl-N-[2-[4-[(4-Methylcyclohexyl)Carbamoylsulfamoyl]Phenyl]Ethyl]-5-Oxo-2H-Pyrrole-1-Carboxamide 490.22
BXGC0025757 Calcimycin 523.27
BXGC0025887 5-Hydroxyflavone 238.06
BXGC0026480 Osajin 404.16
BXGC0026894 5,7-Dihydroxy-3-(4-Hydroxyphenyl)-6,8-Bis(3-Methylbut-2-Enyl)Chromen-4-One 406.18
BXGC0027102 Esculin 340.08
BXGC0029234 Gluconolactone 178.05
BXGC0029390 Nodakenetin Tiglate 328.13
BXGC0030010 Michler's Ketone 268.16
BXGC0030138 Colchicine 399.17
BXGC0030696 2,3-Dimethoxyxanthen-9-One 256.07
BXGC0033291 2-(4-Hydroxyphenyl)-7-Methoxychromen-4-One 268.07
BXGC0034035 Capsaicin 305.2
BXGC0035575 6-(2-Methylbut-3-En-2-Yl)Furo[3,2-G]Chromen-7-One 254.09
BXGC0036541 Dibenzoylmethane 224.08
BXGC0036860 Helenalin 262.12
BXGC0037016 4'-Methoxyflavone 252.08
BXGC0038400 [(9R,10R)-8,8-Dimethyl-9-[(Z)-2-Methylbut-2-Enoyl]Oxy-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-10-Yl] (Z)-2-Methylbut-2-Enoate 426.17
BXGC0038744 calystegine B(2) 175.08
BXGC0038823 3-Epifagomine 147.09
BXGC0039019 Harmol 198.08
BXGC0040213 CEPHARANTHINE 606.27
BXGC0041132 Duvoglustat 163.08
BXGC0042519 Glimepiride 490.22
BXGC0042546 5-Hydroxy-2-(4-Hydroxyphenyl)-7-Methoxy-2,3-Dihydrochromen-4-One 286.08
BXGC0042870 Piceatannol 244.07
BXGC0043001 Xanthone 196.05
BXGC0043126 Nicardipine 479.21
BXGC0045254 Sb-202190 331.11
BXGC0045812 Trifluoperazine 407.16
BXGC0045813 Alpha-5-C-(3-Hydroxybutyl)Hyacinthacine A1 245.16
BXGC0047169 Hymecromone 176.05
BXGC0047867 Dalfampridine 94.05
BXGC0048313 Rosmarinic Acid 360.08
BXGC0048379 camptothecin 348.11
BXGC0048661 Nicardipine Hydrochloride 479.21
BXGC0049447 acetate 59.01
BXGC0049562 L-1-Deoxynojirimycin 163.08
BXGC0049633 4-Aminophenol 109.05
BXGC0050123 Cepharanthine 606.27
BXGC0050194 alpha-D-Mannose 180.06
BXGC0050422 n.a 193.1
BXGC0050608 Fagomine 147.09
BXGC0050754 Cytisine 190.11
BXGC0053544 Actein 676.38
BXGC0053852 Scyllitol 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein