Showing entry for Potassium voltage-gated channel subfamily A member 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008774
Protein NamePotassium voltage-gated channel subfamily A member 5
Uniport IdP22460
GeneKCNA5
Gene Id3741
DomainBTB_2; Ion_trans
Pfam PF02214   PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086014 atrial cardiac muscle cell action potential
Biological Process GO:0060081 membrane hyperpolarization
Biological Process GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential
Biological Process GO:0086050 membrane repolarization during bundle of His cell action potential
Biological Process GO:0086052 membrane repolarization during SA node cell action potential
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Biological Process GO:2000288 positive regulation of myoblast proliferation
Biological Process GO:0097623 potassium ion export across plasma membrane
Biological Process GO:0055075 potassium ion homeostasis
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0043266 regulation of potassium ion transport
Biological Process GO:0019229 regulation of vasoconstriction
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0055093 response to hyperoxia
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0010033 response to organic substance
molecular function GO:0051393 alpha-actinin binding
molecular function GO:0005251 delayed rectifier potassium channel activity
molecular function GO:0015271 outward rectifier potassium channel activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0097110 scaffold protein binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0005249 voltage-gated potassium channel activity
molecular function GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
molecular function GO:0086087 voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
molecular function GO:0086090 voltage-gated potassium channel activity involved in SA node cell action potential repolarization
cellular component GO:0009986 cell surface
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0014704 intercalated disc
cellular component GO:0046691 intracellular canaliculus
cellular component GO:0045121 membrane raft
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0034705 potassium channel complex
cellular component GO:0008076 voltage-gated potassium channel complex
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296072 Voltage gated Potassium channels
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0035828 BXGD002566 Romano-Ward Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206525 BXGD004179 Tuberculosis, Drug-Resistant Infections
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0270862 BXGD006125 Hemiplegic migraine Nervous System Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0340489 BXGD007336 Lone atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0393576 BXGD008096 Chorea Acanthocytosis Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393584 BXGD008099 Benign Hereditary Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684219 BXGD009789 Myokymia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C1141890 BXGD011721 Congenital long QT syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1333978 BXGD012664 Hepatitis C Virus-Related Hepatocellular Carcinoma
C1701938 BXGD013524 Associated Pulmonary Arterial Hypertension Respiratory Tract Diseases
C1719788 BXGD013661 Episodic ataxia type 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1843687 BXGD014602 ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1868682 BXGD016525 Paroxysmal kinesigenic choreoathetosis Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2585653 BXGD017139 Persistent atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2677106 BXGD017361 Atrial Fibrillation, Familial, 7 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3160712 BXGD018467 Palpitations, CTCAE
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3468561 BXGD018908 familial atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4551647 BXGD023381 Long QT Syndrome 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001837 Quercetin 3-rutinoside 610.52
BXGC0001842 Bergapten 216.19
BXGC0001868 Catechin 290.27
BXGC0002043 Acacetin 284.26
BXGC0003804 4'-Methylgenkwanin 298.29
BXGC0005793 Baicalein 270.24
BXGC0024988 Nifedipine 346.12
BXGC0027076 Oroidin 386.93
BXGC0035201 Quinidine 324.18
BXGC0037016 4'-Methoxyflavone 252.08
BXGC0044017 Verapamil 454.28
BXGC0047867 Dalfampridine 94.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein