Showing entry for N,N-Dimethyltryptamine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0050172
Compound NameN,N-Dimethyltryptamine
Structure
FormulaC12H16N2
InchiKeyDMULVCHRPCFFGV-UHFFFAOYSA-N
SMILESCN(CCc1c[nH]c2c1cccc2)C
InchiInChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
IUPAC2-(1H-indol-3-yl)-N,N-dimethylethanamine
Molecular Weight188.13
Pubchem Id6089
Chembl IdCHEMBL12420
Targets of Information Source
DrugBank DB01488
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 experimental; illicit -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A experimental; illicit -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 experimental; illicit -
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50026868
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 42 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 68 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 65 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 101 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 259 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 33 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 1636 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 410 - - -
reviewed BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 15000 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b - - 1000 -
CHEMBL CHEMBL12420
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 1636 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Efficacy - - -
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 410 nM
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Kd '=' 1000 nM
P28565 BXGT009273 5-hydroxytryptamine receptor 1D reviewed - Htr1d Kd '=' 1000 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Kd '=' 1000 nM
P35364 BXGT009819 5-hydroxytryptamine receptor 5A reviewed - Htr5a Kd '=' 1000 nM
P30940 BXGT009484 5-hydroxytryptamine receptor 1F reviewed - Htr1f Kd '=' 1000 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Kd '=' 1000 nM
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Kd '=' 1000 nM
Q62758 BXGT016041 5-hydroxytryptamine receptor 4 reviewed - Htr4 Kd '=' 1000 nM
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Kd '=' 1000 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Kd '=' 1000 nM
Q9JJ16 BXGT020824 5-hydroxytryptamine receptor 3B reviewed - Htr3b Kd '=' 1000 nM
P31388 BXGT009532 5-hydroxytryptamine receptor 6 reviewed - Htr6 Kd '=' 1000 nM
P32305 BXGT009621 5-hydroxytryptamine receptor 7 reviewed - Htr7 Kd '=' 1000 nM
P35365 BXGT009820 5-hydroxytryptamine receptor 5B reviewed - Htr5b Kd '=' 1000 nM
P35563 BXGT009849 5-hydroxytryptamine receptor 3A reviewed - Htr3a Kd '=' 1000 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a ED50 '=' 3 mg.kg-1
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a ED50 '=' 10 umol.kg-1
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 65 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 101 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 33 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '=' 259 nM
Q9ES14 BXGT020314 Gamma-aminobutyric acid receptor subunit epsilon reviewed - Gabre Ki '>' 100000 nM
Q91ZM7 BXGT019327 GABA theta subunit unreviewed - Gabrq Ki '>' 100000 nM
P63138 BXGT011502 Gamma-aminobutyric acid receptor subunit beta-2 reviewed - Gabrb2 Ki '>' 100000 nM
P63079 BXGT011491 Gamma-aminobutyric acid receptor subunit beta-3 reviewed - Gabrb3 Ki '>' 100000 nM
P62813 BXGT011460 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed - Gabra1 Ki '>' 100000 nM
P30191 BXGT009410 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed - Gabra6 Ki '>' 100000 nM
P28473 BXGT009261 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed - Gabrg3 Ki '>' 100000 nM
P28471 BXGT009259 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed - Gabra4 Ki '>' 100000 nM
P23576 BXGT008885 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed - Gabra2 Ki '>' 100000 nM
P23574 BXGT008884 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed - Gabrg1 Ki '>' 100000 nM
P20236 BXGT008551 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed - Gabra3 Ki '>' 100000 nM
P19969 BXGT008536 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed - Gabra5 Ki '>' 100000 nM
P18508 BXGT008412 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed - Gabrg2 Ki '>' 100000 nM
P18506 BXGT008410 Gamma-aminobutyric acid receptor subunit delta reviewed - Gabrd Ki '>' 100000 nM
P15431 BXGT008122 Gamma-aminobutyric acid receptor subunit beta-1 reviewed - Gabrb1 Ki '>' 100000 nM
O09028 BXGT004049 Gamma-aminobutyric acid receptor subunit pi reviewed - Gabrp Ki '>' 100000 nM
Q60492 BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 15000 nM
Q9R0C9 BXGT021402 Sigma non-opioid intracellular receptor 1 reviewed - Sigmar1 Ki '=' 15400 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00008 Garlic Allium sativum Herbs and Spices
BXGF02702 Arundo donax Arundo donax Medicinal Plant
BXGF05910 Desmodium gangeticum Desmodium gangeticum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease