Showing entry for 5-hydroxytryptamine receptor 2B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010267
Protein Name5-hydroxytryptamine receptor 2B
Uniport IdP41595
GeneHTR2B
Gene Id3357
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007202 activation of phospholipase C activity
Biological Process GO:0007610 behavior
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0003300 cardiac muscle hypertrophy
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071502 cellular response to temperature stimulus
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0048598 embryonic morphogenesis
Biological Process GO:0070371 ERK1 and ERK2 cascade
Biological Process GO:0002031 G protein-coupled receptor internalization
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0014827 intestine smooth muscle contraction
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0014033 neural crest cell differentiation
Biological Process GO:0001755 neural crest cell migration
Biological Process GO:0014065 phosphatidylinositol 3-kinase signaling
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0016310 phosphorylation
Biological Process GO:0051781 positive regulation of cell division
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0001819 positive regulation of cytokine production
Biological Process GO:0050715 positive regulation of cytokine secretion
Biological Process GO:0001938 positive regulation of endothelial cell proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0043406 positive regulation of MAP kinase activity
Biological Process GO:0051000 positive regulation of nitric-oxide synthase activity
Biological Process GO:0010513 positive regulation of phosphatidylinositol biosynthetic process
Biological Process GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0070528 protein kinase C signaling
Biological Process GO:0050795 regulation of behavior
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0042493 response to drug
Biological Process GO:0007210 serotonin receptor signaling pathway
Biological Process GO:0042310 vasoconstriction
molecular function GO:0008144 drug binding
molecular function GO:0001965 G-protein alpha-subunit binding
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0004993 G protein-coupled serotonin receptor activity
molecular function GO:0005096 GTPase activator activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0051378 serotonin binding
cellular component GO:0005737 cytoplasm
cellular component GO:0030425 dendrite
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-390666 Serotonin receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003431 BXGD000190 Antisocial Personality Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018824 BXGD001237 Heart valve disease Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024809 BXGD001808 Marijuana Abuse Chemically-Induced Disorders; Mental Disorders
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0032897 BXGD002378 Prader-Willi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0034091 BXGD002463 Pulmonary Veno-Occlusive Disease (disorder) Respiratory Tract Diseases; Cardiovascular Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040517 BXGD002872 Gilles de la Tourette syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0079485 BXGD003078 Heart Valve Prolapse Cardiovascular Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086025 BXGD003262 Codependency Behavior and Behavior Mechanisms
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0236969 BXGD004842 Substance-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0338480 BXGD007186 Common Migraine Nervous System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0564567 BXGD009486 Impulsive character (finding)
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1608408 BXGD013434 Malignant transformation
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2939447 BXGD018179 Right ventricular failure Cardiovascular Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4284120 BXGD022436 Ecstasy related disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000226 Glycine 75.07
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000286 L-DOPA 197.19
BXGC0000433 Triacetin 218.2
BXGC0000434 Ethanol 46.07
BXGC0000439 Chloroform 119.38
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000528 Salicylic acid 138.12
BXGC0000536 Phenol 94.11
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000548 Tryptamine 160.22
BXGC0000622 Nicotinic acid 123.11
BXGC0000663 Papain 206.28
BXGC0000759 Arabinan 243.22
BXGC0000764 L-Ascorbic acid 176.12
BXGC0000894 2-Methylthioribosyl-trans-zeatin 323.8
BXGC0001000 4,8,5'-Trimethylpsoralen 228.24
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001325 Progesterone 314.46
BXGC0001502 Caffeine 194.19
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002012 (Z)-Isoeugenol 164.2
BXGC0002402 Ethyl carbamate 89.09
BXGC0002437 Lactic acid 90.08
BXGC0002441 Hydroxyacetic acid 76.05
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002796 Nicotine 162.23
BXGC0002867 Lappaurin 284.74
BXGC0002906 Caffeic acid ester 284.31
BXGC0002916 Melatonin 232.28
BXGC0003066 Phenols 199.27
BXGC0003131 N,N-Dimethylformamide 73.09
BXGC0003196 Aripiprazole 448.39
BXGC0003501 Parthenolide 248.32
BXGC0003502 Phenylhydrazine 108.14
BXGC0003610 5-Hydroxy-L-tryptophan 220.22
BXGC0003611 Latex 416.57
BXGC0003690 Glucokinin 764.94
BXGC0003707 Estrogen 268.36
BXGC0003773 Estriol 288.38
BXGC0003956 Fenugrin E 178.19
BXGC0004261 Propylene glycol 76.09
BXGC0004287 Allyl alcohol 58.08
BXGC0004556 1,2,3-Benzenetriol 126.11
BXGC0004560 Benzoic acid 122.12
BXGC0004565 Benzyl alcohol 108.14
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0004712 Methylparaben 152.15
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005508 Safrole 162.19
BXGC0005624 Genistein 270.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005867 Serotonin 176.22
BXGC0005879 Eugenol 164.2
BXGC0006105 Methyl salicylate 152.15
BXGC0006115 Xanthotoxin 216.19
BXGC0006125 Nicotinamide 122.12
BXGC0006156 Dicoumarol 336.3
BXGC0006198 Citric acid 192.12
BXGC0006362 Estrone 270.37
BXGC0006366 trans-Ferulic acid 194.18
BXGC0006372 Ergocalciferol 396.65
BXGC0006389 Rotenone 394.42
BXGC0006422 Mercenene 214.05
BXGC0006982 Geraniol 154.25
BXGC0007601 1,8-Cineole 154.25
BXGC0012228 Vitamin D 384.64
BXGC0012243 Ukonan D 151.16
BXGC0013070 Mescaline 211.12
BXGC0013452 Dioctyl phthalate 390.28
BXGC0014068 Amphetamine 135.1
BXGC0014695 Loratadine 382.14
BXGC0015594 4-Nonylphenol 220.18
BXGC0015987 L-Mimosine 198.06
BXGC0016470 Camptothecin 348.11
BXGC0016671 Leucovorin 473.17
BXGC0016747 Camphor 152.12
BXGC0016891 Nortriptyline 263.17
BXGC0017115 Cephalexin 347.09
BXGC0017369 N-Methyllaurotetanine 341.16
BXGC0017469 2-(2-Hydroxyphenethyl)-5-hydroxychromone 282.09
BXGC0017719 Strychnine 334.17
BXGC0018403 Hydroxyprogesterone 330.22
BXGC0018491 Methylprednisolone 374.21
BXGC0019117 Tannic Acid 1700.17
BXGC0019164 Raloxifene 473.17
BXGC0020355 Fomepizole 82.05
BXGC0020800 Testosterone 288.21
BXGC0021077 Aconitine 645.31
BXGC0021478 Lipoic Acid 206.04
BXGC0022544 Digoxin 780.43
BXGC0024141 Hydrocortisone 362.21
BXGC0024386 Atractyloside 724.21
BXGC0024413 Emetine 480.3
BXGC0024729 Mercaptopurine 152.02
BXGC0024988 Nifedipine 346.12
BXGC0025658 Vinblastine 810.42
BXGC0026391 Naloxone 327.15
BXGC0026468 roemerine 279.13
BXGC0026595 Glycyrrhizin 822.4
BXGC0027374 Glyburide 493.14
BXGC0027421 Paclitaxel 853.33
BXGC0027854 Ethosuximide 141.08
BXGC0028885 Secobarbital 238.13
BXGC0030138 Colchicine 399.17
BXGC0030663 Metformin 129.1
BXGC0030685 Physostigmine 275.16
BXGC0030954 roemerine 279.13
BXGC0031384 Epinephrine 183.09
BXGC0031622 Podofilox 414.13
BXGC0032368 Sparteine 234.21
BXGC0033776 Cycloheximide 281.16
BXGC0034035 Capsaicin 305.2
BXGC0034768 Vincristine 824.4
BXGC0034778 Artemisinin 282.15
BXGC0034783 Doxorubicin 543.17
BXGC0035519 Amygdalin 457.16
BXGC0037718 Ethacrynic Acid 302.01
BXGC0038963 Dichlorvos 219.95
BXGC0039091 1-(3,4,5-Trimethoxyphenyl)Propan-2-Amine 225.14
BXGC0039601 Levocarnitine 161.11
BXGC0039684 Berberine Chloride 336.12
BXGC0040042 Warfarin 308.1
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0040582 nantenine 339.15
BXGC0041240 Atenolol 266.16
BXGC0042099 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole 214.15
BXGC0042127 Oxyquinoline 145.05
BXGC0042179 Atropine 289.17
BXGC0042211 4-Octylphenol 206.17
BXGC0042222 Propranolol 259.16
BXGC0042339 Terbutaline 225.14
BXGC0042452 Panthenol 205.13
BXGC0042510 Fluoxetine 309.13
BXGC0042519 Glimepiride 490.22
BXGC0042596 Isoniazid 137.06
BXGC0043578 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One 266.09
BXGC0043648 (-)-Camphor 152.12
BXGC0044017 Verapamil 454.28
BXGC0044810 Lamivudine 229.05
BXGC0045812 Trifluoperazine 407.16
BXGC0046139 Aminoglutethimide 232.12
BXGC0046755 Yohimbine 354.19
BXGC0046862 Benzo[Def]Chrysene 252.09
BXGC0046996 Thioguanine 167.03
BXGC0047126 Artemether 298.18
BXGC0049391 Betadex 1134.37
BXGC0049738 Dexibuprofen 206.13
BXGC0050172 N,N-Dimethyltryptamine 188.13
BXGC0050471 Fluorouracil 130.02
BXGC0050816 Galantamine 287.15
BXGC0051314 Nuciferine 295.16
BXGC0051524 Ouabain 584.28
BXGC0051982 Mannitol 182.08
BXGC0052021 (R)-Ibuprophen 206.13
BXGC0052374 Reserpine 608.27
BXGC0052798 5-Meo-Dmt 218.14
BXGC0052878 Bisphenol A 228.12
BXGC0053118 Streptomycin 581.27
BXGC0053261 Antimycin A 548.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein