adisease

Showing entry for Bone neoplasms

General Disease Information
BXGD Id	BXGD000357
Disease Name	Bone neoplasms
Disease CUI Id	C0005967
MeSH Codes	C04 C05
Disease Class Name	Neoplasms; Musculoskeletal Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0002664 HP:0000924
Human Phenotype Ontology Term	Neoplasm; Abnormality of the skeletal system
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00469	BXGT003926	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	5352	reviewed	Enzyme
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O15438	BXGT004168	Canalicular multispecific organic anion transporter 2	8714	reviewed	Transporter
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60858	BXGT004903	E3 ubiquitin-protein ligase TRIM13	10206	reviewed
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02818	BXGT005969	Osteocalcin	632	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08670	BXGT006810	Vimentin	7431	reviewed
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12429	BXGT007814	Annexin A3	306	reviewed
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21860	BXGT008698	Receptor tyrosine-protein kinase erbB-3	2065	reviewed	Kinase
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P39900	BXGT010148	Macrophage metalloelastase	4321	reviewed	Enzyme
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41240	BXGT010242	Tyrosine-protein kinase CSK	1445	reviewed	Kinase
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51812	BXGT010893	Ribosomal protein S6 kinase alpha-3	6197	reviewed	Kinase
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16769	BXGT013665	Glutaminyl-peptide cyclotransferase	25797	reviewed	Enzyme
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q96GD0	BXGT019665	Pyridoxal phosphate phosphatase	57026	reviewed	Enzyme
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9H4W6	BXGT020478	Transcription factor COE3	253738	reviewed
Q9Y6Q9	BXGT022338	Nuclear receptor coactivator 3	8202	reviewed	Kinase
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
Q01543	BXGT023137	Friend leukemia integration 1 transcription factor	2313	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}