protein

Showing entry for Growth/differentiation factor 2

General Target Information
BXGT Id	BXGT023094
Protein Name	Growth/differentiation factor 2
Uniport Id	Q9UK05
Gene	GDF2
Gene Id	2658
Domain	TGFb_propeptide; TGF_beta
Pfam	PF00019 PF00688
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.3 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0032924	activin receptor signaling pathway
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0048514	blood vessel morphogenesis
Biological Process	GO:0030509	BMP signaling pathway
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis
Biological Process	GO:0051216	cartilage development
Biological Process	GO:0006879	cellular iron ion homeostasis
Biological Process	GO:0071773	cellular response to BMP stimulus
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process
Biological Process	GO:0008156	negative regulation of DNA replication
Biological Process	GO:0010596	negative regulation of endothelial cell migration
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation
Biological Process	GO:0001503	ossification
Biological Process	GO:0001649	osteoblast differentiation
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0030513	positive regulation of BMP signaling pathway
Biological Process	GO:0061036	positive regulation of cartilage development
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation
Biological Process	GO:0032757	positive regulation of interleukin-8 production
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0060395	SMAD protein signal transduction
Biological Process	GO:0001570	vasculogenesis
molecular function	GO:0005125	cytokine activity
molecular function	GO:0008083	growth factor activity
cellular component	GO:0070062	extracellular exosome
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space

Reactome

Pathway Id	Pathway Name
R-HSA-162582	Signal Transduction
R-HSA-201451	Signaling by BMP
R-HSA-9006936	Signaling by TGFB family members

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002418	BXGD000112	Amblyopia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0002726	BXGD000125	Amyloidosis	Nutritional and Metabolic Diseases
C0002871	BXGD000132	Anemia	Hemic and Lymphatic Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0003857	BXGD000228	Congenital arteriovenous malformation	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0005684	BXGD000319	Malignant neoplasm of urinary bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695	BXGD000323	Bladder Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005940	BXGD000352	Bone Diseases	Musculoskeletal Diseases
C0005967	BXGD000357	Bone neoplasms	Neoplasms; Musculoskeletal Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006287	BXGD000390	Bronchopulmonary Dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007682	BXGD000471	CNS disorder	Nervous System Diseases
C0007787	BXGD000487	Transient Ischemic Attack	Nervous System Diseases; Cardiovascular Diseases
C0008325	BXGD000529	Cholecystitis	Digestive System Diseases
C0008350	BXGD000531	Cholelithiasis	Digestive System Diseases
C0009241	BXGD000595	Cognition Disorders	Mental Disorders
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010278	BXGD000660	Craniosynostosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011436	BXGD000726	Dentinogenesis Imperfecta	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014591	BXGD000938	Epistaxis	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0014772	BXGD000948	Red Blood Cell Count measurement
C0014867	BXGD000964	Esophageal Varices	Digestive System Diseases
C0015672	BXGD001011	Fatigue	Pathological Conditions, Signs and Symptoms
C0015826	BXGD001022	Fenestration (morphologic abnormality)
C0017181	BXGD001103	Gastrointestinal Hemorrhage	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0018920	BXGD001246	Hemangioma, Cavernous	Neoplasms; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0018965	BXGD001258	Hematuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019079	BXGD001278	Hemoptysis	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020541	BXGD001424	Portal Hypertension	Digestive System Diseases
C0020542	BXGD001425	Pulmonary Hypertension	Respiratory Tract Diseases
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027819	BXGD002043	Neuroblastoma	Neoplasms
C0028259	BXGD002073	Nodule
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0034065	BXGD002454	Pulmonary Embolism	Respiratory Tract Diseases; Cardiovascular Diseases
C0035334	BXGD002539	Retinitis Pigmentosa	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038525	BXGD002768	Subarachnoid Hemorrhage	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039445	BXGD002810	Hereditary hemorrhagic telangiectasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0039446	BXGD002811	Telangiectasis	Cardiovascular Diseases
C0042373	BXGD002978	Vascular Diseases	Cardiovascular Diseases
C0042487	BXGD002986	Venous Thrombosis	Cardiovascular Diseases
C0085576	BXGD003188	Iron-Refractory Iron Deficiency Anemia	Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0085580	BXGD003191	Essential Hypertension	Cardiovascular Diseases
C0085605	BXGD003200	Liver Failure	Digestive System Diseases
C0149931	BXGD003388	Migraine Disorders	Nervous System Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0152171	BXGD003552	Idiopathic pulmonary hypertension	Respiratory Tract Diseases; Cardiovascular Diseases
C0153676	BXGD003679	Secondary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0153690	BXGD003684	Secondary malignant neoplasm of bone	Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0154835	BXGD003748	Retinal telangiectasia	Cardiovascular Diseases
C0155016	BXGD003765	Color Blindness, Red-Green	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0158570	BXGD003892	Vascular anomaly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0162770	BXGD003980	Right Ventricular Hypertrophy	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0220630	BXGD004302	Adult Liver Carcinoma	Digestive System Diseases; Neoplasms
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239105	BXGD004962	Conjunctival telangiectasis
C0239946	BXGD005010	Fibrosis, Liver	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0242383	BXGD005160	Age related macular degeneration	Eye Diseases
C0242994	BXGD005205	Hantavirus Infections	Infections
C0278488	BXGD006515	Carcinoma breast stage IV
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0279000	BXGD006622	Liver and Intrahepatic Biliary Tract Carcinoma	Digestive System Diseases; Neoplasms
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0332840	BXGD006900	Amputated structure (morphologic abnormality)	Wounds and Injuries
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0340543	BXGD007344	Familial primary pulmonary hypertension	Respiratory Tract Diseases
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376154	BXGD007980	Skin callus	Skin and Connective Tissue Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0392525	BXGD008052	Nephrolithiasis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0410158	BXGD008408	Muscle damage
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0600452	BXGD009708	Hepatopulmonary Syndrome	Digestive System Diseases; Respiratory Tract Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0699885	BXGD009869	Carcinoma of bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095	BXGD009875	Central neuroblastoma	Neoplasms; Nervous System Diseases
C0730285	BXGD009943	Diabetic macular edema	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0740391	BXGD009987	Middle Cerebral Artery Occlusion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0871470	BXGD011316	Systolic Pressure
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1150929	BXGD011768	2-oxo-hept-3-ene-1,7-dioate hydratase activity
C1257915	BXGD011813	Intestinal Polyposis	Digestive System Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1318485	BXGD012394	Liver regeneration disorder	Digestive System Diseases
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1397307	BXGD012996	Cardiac fibrosis
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1519670	BXGD013241	Tumor Angiogenesis	Pathological Conditions, Signs and Symptoms
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1623038	BXGD013475	Cirrhosis	Pathological Conditions, Signs and Symptoms
C1697453	BXGD013507	Spontaneous hematomas
C1699634	BXGD013522	HER-2 positive breast cancer
C1739135	BXGD013733	Progression of prostate cancer
C1860405	BXGD015983	Snowflake vitreoretinal degeneration	Eye Diseases
C1868851	BXGD016538	Pulmonary arterial hypertension associated with portal hypertension	Respiratory Tract Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C1960398	BXGD016658	HER2-positive carcinoma of breast	Neoplasms; Skin and Connective Tissue Diseases
C1961121	BXGD016675	Congenital vascular anomaly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2937358	BXGD018159	Cerebral Hemorrhage	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C2973725	BXGD018205	Pulmonary arterial hypertension	Respiratory Tract Diseases; Cardiovascular Diseases
C3203102	BXGD018555	Idiopathic pulmonary arterial hypertension	Respiratory Tract Diseases
C3241937	BXGD018578	Nonalcoholic Steatohepatitis	Digestive System Diseases
C3274515	BXGD018653	Severe Bronchopulmonary Dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C3278509	BXGD018742	Spinal fusion
C3714636	BXGD019421	Pneumonitis	Infections; Respiratory Tract Diseases
C3809710	BXGD019606	TELANGIECTASIA, HEREDITARY HEMORRHAGIC, TYPE 5
C3809715	BXGD019607	Spontaneous, recurrent epistaxis	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C4021971	BXGD020848	Peripheral arteriovenous fistula	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4021977	BXGD020853	Visceral angiomatosis
C4022018	BXGD020872	Telangiectasia of the skin	Cardiovascular Diseases
C4086165	BXGD022126	Childhood Neuroblastoma	Neoplasms
C4524092	BXGD023092	Chronic rhinosinusitis with nasal polyps
C4551861	BXGD023428	Telangiectasia, Hereditary Hemorrhagic, Type 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}