Showing entry for Hereditary Breast and Ovarian Cancer Syndrome


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD009728
Disease NameHereditary Breast and Ovarian Cancer Syndrome
Disease CUI IdC0677776
MeSH Codes C16   C04   C13   C17   C19  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Endocrine System Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:630   DOID:225  
Disease Ontology Class Namegenetic disease; syndrome
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P07477 BXGT006629 Trypsin-1 5644 reviewed Enzyme
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P12830 BXGT007852 Cadherin-1 999 reviewed
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 3292 reviewed Enzyme
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P29034 BXGT009309 Protein S100-A2 6273 reviewed Calcium-binding protein
P29320 BXGT009332 Ephrin type-A receptor 3 2042 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43351 BXGT010380 DNA repair protein RAD52 homolog 5893 reviewed Nucleic acid binding
P49959 BXGT010766 Double-strand break repair protein MRE11 4361 reviewed
P52701 BXGT010943 DNA mismatch repair protein Msh6 2956 reviewed Nucleic acid binding
P54278 BXGT011038 Mismatch repair endonuclease PMS2 5395 reviewed Nucleic acid binding
P56937 BXGT011205 3-keto-steroid reductase 51478 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P80365 BXGT011895 Corticosteroid 11-beta-dehydrogenase isozyme 2 3291 reviewed Enzyme
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q14562 BXGT013483 ATP-dependent RNA helicase DHX8 1659 reviewed Enzyme
Q6UWP2 BXGT016567 Dehydrogenase/reductase SDR family member 11 79154 reviewed Enzyme
Q86YC2 BXGT017633 Partner and localizer of BRCA2 79728 reviewed
Q96S37 BXGT019737 Solute carrier family 22 member 12 116085 reviewed Transporter
Q99728 BXGT019956 BRCA1-associated RING domain protein 1 580 reviewed
Q9NTK5 BXGT021213 Obg-like ATPase 1 29789 reviewed Enzyme modulator
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
P35240 BXGT022927 Merlin 4771 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q92878 BXGT023071 DNA repair protein RAD50 10111 reviewed
P07320 BXGT026150 Gamma-crystallin D 1421 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease