Showing entry for T-box transcription factor T


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004135
Protein NameT-box transcription factor T
Uniport IdO15178
GeneTBXT
Gene Id6862
DomainT-box
Pfam PF00907  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008595 anterior/posterior axis specification, embryo
Biological Process GO:0060349 bone morphogenesis
Biological Process GO:0001708 cell fate specification
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0061371 determination of heart left/right asymmetry
Biological Process GO:0048706 embryonic skeletal system development
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0007498 mesoderm development
Biological Process GO:0001707 mesoderm formation
Biological Process GO:0007509 mesoderm migration involved in gastrulation
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0001839 neural plate morphogenesis
Biological Process GO:0001843 neural tube closure
Biological Process GO:0014028 notochord formation
Biological Process GO:0007341 penetration of zona pellucida
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
Biological Process GO:0036342 post-anal tail morphogenesis
Biological Process GO:0090009 primitive streak formation
Biological Process GO:0007165 signal transduction
Biological Process GO:0023019 signal transduction involved in regulation of gene expression
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0001756 somitogenesis
Biological Process GO:0001570 vasculogenesis
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0001102 RNA polymerase II activating transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002902 BXGD000154 Anencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007097 BXGD000424 Carcinoma Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008487 BXGD000545 Chordoma Neoplasms
C0011999 BXGD000770 Diastematomyelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0023798 BXGD001702 Lipoma Neoplasms
C0025312 BXGD001861 Meningomyelocele Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027806 BXGD002039 Neurenteric Cyst Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0080174 BXGD003106 Spina Bifida Occulta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0080218 BXGD003109 Tethered Cord Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0152234 BXGD003566 Iniencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0152426 BXGD003589 Craniorachischisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266215 BXGD005632 Anorectal atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0266453 BXGD005671 Exencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0344479 BXGD007677 Spinal Cord Myelodysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0344490 BXGD007680 Sacral agenesis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0426848 BXGD008590 Sacral dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0702169 BXGD009914 Acrania Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0745730 BXGD010132 Multiple lipomata Neoplasms
C0812426 BXGD010848 Kidney problem
C1834129 BXGD013957 Abnormal vertebral morphology
C1845052 BXGD014704 AMELOGENESIS IMPERFECTA, HYPOPLASTIC/HYPOMATURATION, X-LINKED 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C1960883 BXGD016670 Spina bifida aperta of cervical spine Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3810343 BXGD019649 SACRAL AGENESIS WITH VERTEBRAL ANOMALIES
C3891448 BXGD020030 NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO
C4024669 BXGD021364 Asymmetry of spinal facet joints
C4733128 BXGD023911 familial chordoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein